(S,R,S)-AHPC-PEG4-ALKYNE
- CAS No.
- 2267282-21-1
- Chemical Name:
- (S,R,S)-AHPC-PEG4-ALKYNE
- Synonyms
- (S,R,S)-AHPC-PEG4-ALKYNE;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(4,7,10,13-tetraoxahexadec-15-ynamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
- CBNumber:
- CB54742695
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
(S,R,S)-AHPC-PEG4-ALKYNE price More Price(2)
(S,R,S)-AHPC-PEG4-ALKYNE Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
(S,R,S)-AHPC-PEG4-ALKYNE Preparation Products And Raw materials
Raw materials
Preparation Products
(S,R,S)-AHPC-PEG4-ALKYNE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1385 | 58 |
Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 | 2853979819@qq.com | China | 9530 | 58 |
Elucigen bio | 13501719342 | wayne.zheng@elucigenbio.com | China | 4587 | 58 |
View Lastest Price from (S,R,S)-AHPC-PEG4-ALKYNE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | (S,R,S)-AHPC-PEG4-Alkyne
2267282-21-1
|
US $0.00 / mg | 100mg | >99.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
- (S,R,S)-AHPC-PEG4-Alkyne
2267282-21-1
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.