ChemicalBook
Chinese Japanese Germany Korea

Diclofenac sodium

Uses Mechanisms of action Clinical Application
Diclofenac sodium
Diclofenac sodium structure
CAS No.
15307-79-6
Chemical Name:
Diclofenac sodium
Synonyms
Naclof;Voldal;KROPLEX;Diacron;gp45840;kriplex;ortofen;VALETAN;BENFOFEN;Naclofen
CBNumber:
CB5474464
Molecular Formula:
C14H10Cl2NNaO2
Formula Weight:
318.13
MOL File:
15307-79-6.mol

Diclofenac sodium Properties

Melting point:
288-290°C
Density 
0.781 g/cm3
storage temp. 
-20°C Freezer
solubility 
H2O: 50 mg/mL
form 
White solid
pka
4(at 25℃)
Water Solubility 
Soluble in water to 50mg/ml.
Merck 
14,3081
Stability:
Stable.
InChIKey
KPHWPUGNDIVLNH-UHFFFAOYSA-M
CAS DataBase Reference
15307-79-6(CAS DataBase Reference)
FDA UNII
QTG126297Q
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H361-H301
Precautionary statements  P201-P280-P301+P310a-P308+P313-P501a-P301+P310-P264-P270-P301+P310+P330-P405-P501
Hazard Codes  T,Xi
Risk Statements  25-36/37/38-63
Safety Statements  22-36/37-45-36-26-60-20
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  AG6330000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29224999
Toxicity LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp)

Diclofenac sodium price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 287840 Diclofenac Sodium 15307-79-6 1gm $42.5 2019-12-02 Buy
Sigma-Aldrich 1188800 Diclofenac sodium United States Pharmacopeia (USP) Reference Standard 15307-79-6 200mg $352.8 2019-12-02 Buy
TCI Chemical D2508 Diclofenac Sodium Salt >98.0%(HPLC)(N) 15307-79-6 25g $59 2019-12-02 Buy
Alfa Aesar J62609 Diclofenac sodium salt 15307-79-6 25g $65.5 2019-12-02 Buy
Alfa Aesar J62609 Diclofenac sodium salt 15307-79-6 5g $28.7 2019-12-02 Buy

Diclofenac sodium Chemical Properties,Uses,Production

Uses

Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain.

Mechanisms of action

Putative mechanisms of action of diclofenac may include inhibition of leukotriene synthesis, inhibition of phospholipase A2, modulation of free arachidonic acid levels, stimulation of adenosine triphosphate-sensitive potassium channels via the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway and centrally mediated and neuropathic mechanisms. Other emerging mechanisms of action may include inhibition of peroxisome proliferator activated receptor-c, reduction in plasma and synovial substance P and interleukin-6 levels, inhibition of the thromboxane-prostanoid receptor and inhibition of acid-sensing ion channels.

Clinical Application

Clinical trials have demonstrated the analgesic efficacy of diclofenac sodium in terms of relieving moderate to severe postoperative pain in patients undergoing dental surgery or minor orthopaedic surgery. Subcutaneous diclofenac sodium also effectively relieved moderate to severe neuropathic pain, related to cancer or not. Diclofenac sodium was generally well tolerated in clinical trials, with injection-site reactions among the most commonly reported adverse events.

Chemical Properties

Off-White Crystalline Solid

Uses

A nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.

Uses

An inhibitor of Cox-1 and Cox-2.

Uses

A nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor

Definition

ChEBI: The sodium salt of diclofenac.

brand name

Solaraze (Bioglan); Voltaren (Novartis);Aflamin;Alfamin;Allvoran;Artren;Blesin;B-voltaren;Cgp 9194;Chlorgyl;Ct-diclo;Dichloronic;Diclo attritin;Diclo spondril;Diclo-attritin;Diclo-burg;Diclo-phlohont;Diclo-puren;Diclo-recip;Dicloreum;Diclo-spondyril;Diclo-wolf;Dolobasan;Dolotrem;Doragon;Duravolten;Duvavotten;Feloran;Fenoflam;Flogofenac;Flogogenac;Forgenac;Inflamac;Klast;Monoflam;Myogit;Neuro-effekton;Neurofenac;Neuro-voltaren;Neviodin;Olfen;Panamor;Rewodina;Rheumalgen;Rheumavincin-n;Seecoren;Shignol;Silino;Sofarin;Thicataren;Toryxil;Tsudomin;Voltarene.

World Health Organization (WHO)

The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.

Veterinary Drugs and Treatments

The equine topical cream (Surpass?) is labeled for the control of pain and inflammation associated with osteoarthritis in tarsal, carpal, metacarpophalangeal, metarsophalangeal, and proximal interphalangeal (hock, knee, fetlock, pastern) joints for use up to 10 days duration. While, theoretically, diclofenac could be used systemically (orally) in other veterinary species, there are approved and safer alternatives.

Diclofenac sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Diclofenac sodium Suppliers

Global( 406)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales01@yibaibiotech.com CHINA 419 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 569 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24697 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2368 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1010 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30052 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hebei Huanhao Biotechnology Co., Ltd.
86-18034554576 whatsapp +8618034554576
86-0311-83975816 grace@hbhuanhao.com CHINA 721 58

Related articles


View Lastest Price from Diclofenac sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-02 Diclofenac sodium Manufacturer; In stock GMP Factory
15307-79-6
US $1.00 / KG 1KG High quality manufacturer TOP 3 largest production factory in China Chemwill Asia Co.,Ltd.
2019-08-16 Diclofenac Sodium
15307-79-6
US $0.00-0.00 / T 1g 99% 20T/Month Beijing Yibai Biotechnology Co., Ltd
2019-04-22 Diclofenac Sodium 15307-79-6
15307-79-6
US $1.00 / g 1g 99% 5000 Kilogram/Kilograms Cangzhou Wanyou New Material Technology Co.,Ltd

Diclofenac sodium Spectrum


15307-79-6(Diclofenac sodium)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved