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Pemigatinib

Pemigatinib structure

CAS No.: 1513857-77-6

Chemical Name:: Pemigatinib

Synonyms: IBI-375;INCB54828;INCB 54828;INCB-54828;INCB-054828;Pemigatinib;2H8]-Pemigatinib;Terbufos Impurity 14 (Ethion);INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic;3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one

CBNumber:: CB54796678

Molecular Formula:: C24H27F2N5O4

Molecular Weight:: 487.5

MDL Number:: MFCD31706227

MOL File:: 1513857-77-6.mol

Last updated:2024-01-02 10:01:40

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Pemigatinib Properties

Boiling point	697.6±55.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:40.0(Max Conc. mg/mL);82.05(Max Conc. mM)
form	A crystalline solid
pka	11.56±0.40(Predicted)
NCI Dictionary of Cancer Terms	pemigatinib
FDA UNII	Y6BX7BL23K
NCI Drug Dictionary	pemigatinib
ATC code	L01EX20

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

Pemigatinib price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0039499	Pemigatinib 99.88%	1513857-77-6	5mg	$120	2021-12-16	Buy
ChemScene	CS-0039499	Pemigatinib 99.88%	1513857-77-6	10mg	$190	2021-12-16	Buy
ChemScene	CS-0039499	Pemigatinib 99.88%	1513857-77-6	25mg	$350	2021-12-16	Buy
ChemScene	CS-0039499	Pemigatinib 99.88%	1513857-77-6	50mg	$550	2021-12-16	Buy
ChemScene	CS-0039499	Pemigatinib 99.88%	1513857-77-6	100mg	$950	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0039499	5mg	$120	Buy
CS-0039499	10mg	$190	Buy
CS-0039499	25mg	$350	Buy
CS-0039499	50mg	$550	Buy
CS-0039499	100mg	$950	Buy

Pemigatinib Chemical Properties,Uses,Production

Uses

Pemigatinib is a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma.

Pemigatinib synthesis

Synthesis of Pemigatinib from 4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE

Pemigatinib Preparation Products And Raw materials

Raw materials

2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-7-(phenylsulfonyl)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-7-(phenylsulfonyl)- 1H-Pyrrolo[2,3-b]pyridine-5-methanamine, N-(2,6-difluoro-3,5-dimethoxyphenyl)-4-(ethylamino)- 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro- 4-(ethylamino)-1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde

4-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBALDEHYDE

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Preparation Products

Pemigatinib Suppliers

Global( 104)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Beijing Mesochem Technology Co.,Ltd	+8613651027935	rachel@mesochem.com	China	191	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	874	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	6452	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Beijing Mesochem Technology Co.,Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Changzhou AniKare Pharmatech Co., Ltd.	58

How is Pemigatinib Synthesised?
Pemigatinib is synthesised using pyrrolopyridine as a raw material, firstly by synthesis of Pemigatinib Morpholine Intermediat....
Jan 2，2024

View Lastest Price from Pemigatinib manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-12-29	Pemigatinib 1513857-77-6	US $0.00-0.00 / kg	1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd
	2023-11-27	Pemigatinib 1513857-77-6	US $0.00-0.00 / mg	10mg	98%	50kg	Wuhan Senwayer Century Chemical Co.,Ltd

Pemigatinib
1513857-77-6
US $0.00-0.00 / kg
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Pemigatinib
1513857-77-6
US $0.00-0.00 / mg
98%
Wuhan Senwayer Century Chemical Co.,Ltd

Pemigatinib Spectrum

Pemigatinib(1513857-77-6)¹HNMR

Pemigatinib 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one INCB-054828 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one 2H-Pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)- IBI-375 3-(2,6-Difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-1,3,4,6-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one 2H8]-Pemigatinib INCB 054828,Fibroblast growth factor receptor,INCB-054828,inhibit,cholangiocarcinoma,Orally,Pemigatinib,FGFR,Inhibitor,antineoplastic Terbufos Impurity 14 (Ethion) INCB 54828 INCB54828 INCB-54828 1513857-77-6 1513857-77-7 C24H27F2N5O4 APIS