CCI 007)
- CAS No.
- 939228-52-1
- Chemical Name:
- CCI 007)
- Synonyms
- CCI 007);CCI-007 (CCI00;Ethyl 2-(4-((2-amino-4-oxothiazol-5(4H)-ylidene)methyl)-2-methoxyphenoxy)acetate;Acetic acid, 2-[4-[(2-amino-4-oxo-5(4H)-thiazolylidene)methyl]-2-methoxyphenoxy]-, ethyl ester;CCI 007,MLL-r,CALM-AF10,HOXA9,MEIS1,Apoptosis,CMYC,CCI-007,SET-NUP214,inhibit,Inhibitor,CCI007
- CBNumber:
- CB54844623
- Molecular Formula:
- C15H16N2O5S
- Molecular Weight:
- 336.36
- MDL Number:
- MFCD34167454
- MOL File:
- 939228-52-1.mol
CCI 007) Chemical Properties,Uses,Production
Biological Activity
CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1]. CCI-007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia[1].Following CCI-007 treatment for 24h, significant mitochondrial depolarization was observed in PER-485 cells as evidenced by a shift in JC-1 signal[1].Resistance to CCI-007 can occur by upregulation of MLL target gene expression[1].CCI-007 reverts the aberrant elevated transcription of disease-driving factors HOXA9, MEIS1, and CMYC downstream of the pathogenic MLL fusion protein, thereby inducing MLL-r leukemia cell death[2]. Cell Viability Assay[1] Cell Line: PER-485, MOLM-13, MV4;11 cells.
References
[1]. Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19;7(29):46067-46087. [2]. Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May;38(20):3824-3842.
CCI 007) Preparation Products And Raw materials
Raw materials
Preparation Products
CCI 007) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 10002 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2992 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 945 | 58 |