cypate
- CAS No.
- 95837-47-1
- Chemical Name:
- cypate
- Synonyms
- cypate;lipo Cypate;lipo Cy7.5(diPrAcid);3-(2-(7-(3-(2-Carboxyethyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)propanoate;3-(2-((1E,3E,5E,7Z)-7-(3-(2-carboxyethyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)propanoate
- CBNumber:
- CB54845150
- Molecular Formula:
- C41H40N2O4
- Molecular Weight:
- 624.78
- MDL Number:
- MFCD33029316
- MOL File:
- 95837-47-1.mol
cypate Chemical Properties,Uses,Production
Uses
Cypate, a cyanine dye, is a near infrared (NIR)fluorescentprobe for in vivo tumor imaging[1][2].
in vivo
Cypate (10 nmol; IV; every 24 hours for 6 days) causes the liver to have the highest accumulation[1].
The fluorescence signal of Cypate (5 mg/kg; IV) in the tumor of mice (Balb/c mice with 4T1 cells) is weak and quickly decayed, possibly due to fast elimination of free cypate from body. Stronger fluorescence in liver and kidney is observed in free cypate group. The Cypate fluorescence signal is assessed using an IVIS Lumina imaging system (Ex-745 nm; Em-800 nm)[2].
| Animal Model: | Foxn1nu/Foxn1nu nude 2.5-month-old female mice with breast cancer cells (MDA-MB-231 Luc2)[1] |
| Dosage: | 10 nmol in 100μL PBS |
| Administration: | IV; every 24 hours for 6 days |
| Result: | The accumulation alone in the tumor was negligible for 24 hours after the injection. The liver had the highest accumulation at all time points. |
References
[1] Mona Doshi, et al. Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging. Mol Pharmacol. 2019 May;95(5):475-489. DOI:10.1124/mol.118.114199
[2] Yuanyuan Li, et al. Light-Decomposable Polymeric Micelles with Hypoxia-Enhanced Phototherapeutic Efficacy for Combating Metastatic Breast Cancer. Pharmaceutics. 2022 Jan 21;14(2):253. DOI:10.3390/pharmaceutics14020253
cypate Preparation Products And Raw materials
Raw materials
Preparation Products
cypate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Xi'an Kaixin Biotechnology Co., Ltd | 029-68881181 13619217766 | 3495811982@qq.com | China | 2810 | 58 |
| Suzhou Su Taike Biological Reagent Co., Ltd. | 0512-0512-65884469 18352410772 | seetech@126.com | China | 4 | 58 |
| Jinan Kewei Biotechnology Co., LTD | 15315592897 | xmxingbjlg@163.com | China | 174 | 58 |
| Okeanos Tech Co,. Ltd. | 010-62651721 18610486005 | minghui.yu@okeanos.com.cn | China | 495 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89689 | 60 |
