ChemicalBook >> CAS DataBase List >>(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT structure

CAS No.: 60-99-1

Chemical Name:: (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

Synonyms: XP 03;rp7044;C07192;Nirvan;skf5116;Sinogan;cl36467;cl39743;cl53212;dedoran

CBNumber:: CB5488571

Molecular Formula:: C19H24N2OS

Molecular Weight:: 328.47

MDL Number:: MFCD00869255

MOL File:: 60-99-1.mol

Last updated:2023-07-12 17:14:42

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Properties

Melting point	117°C
Boiling point	468.0±45.0 °C(Predicted)
Density	1.0897 (rough estimate)
refractive index	1.5950 (estimate)
storage temp.	Store at -20°C
solubility	Chloroform (Slightly), Methanol (Very Slightly)
form	Solid
pka	9.32±0.28(Predicted)
color	White to Off-White
Water Solubility	20mg/L(25 ºC)
FDA UNII	9G0LAW7ATQ
ATC code	N05AA02

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332
Precautionary statements	P261-P280-P301+P312+P330
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36
RIDADR	3249
RTECS	SO6125000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2934302300
Toxicity	LD50 oral in rat: 1100mg/kg

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1415006	Methotrimeprazine maleate salt	60-99-1	200mg	$276	2024-03-01	Buy
TRC	M260770	(R)-Methotrimeprazine	60-99-1	10mg	$1470	2021-12-16	Buy
ChemScene	CS-0013678	Levomepromazine 99.98%	60-99-1	10mg	$85	2021-12-16	Buy
ChemScene	CS-0013678	Levomepromazine 99.98%	60-99-1	50mg	$250	2021-12-16	Buy
ChemScene	CS-0013678	Levomepromazine 99.98%	60-99-1	100mg	$420	2021-12-16	Buy

Product number	Packaging	Price	Buy
1415006	200mg	$276	Buy
M260770	10mg	$1470	Buy
CS-0013678	10mg	$85	Buy
CS-0013678	50mg	$250	Buy
CS-0013678	100mg	$420	Buy

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Uses,Production

Originator

Levoprome ,Lederle,US,1966

Uses

(R)-Methotrimeprazine acts as an analgesic agent.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.

Manufacturing Process

95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.

brand name

Levoprome (Immunex).

Therapeutic Function

Analgesic

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Sodium amide

Preparation Products

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Suppliers

Global( 53)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	305	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58

Supplier	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
Shaanxi Didu New Materials Co. Ltd	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-01-18	Levomepromazine 60-99-1	US $66.00 / kg	1kg	99.98%	1	Xiamen Wonderful Bio Technology Co., Ltd.
	2021-07-24	(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT USP/EP/BP 60-99-1	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

Levomepromazine
60-99-1
US $66.00 / kg
99.98%
Xiamen Wonderful Bio Technology Co., Ltd.

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT USP/EP/BP
60-99-1
US $1.10 / g
99.9%
Dideu Industries Group Limited

60-99-1((-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT)Related Search:

2-Methoxyphenothiazine Phenothiazine (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Methotrimeprazine Sulfoxide

methotrimeprazine maleate rp7044 Sinogan Sinogan-Debil SK&F 5116 SKF 5116 skf5116 Tisercin Veractil (bR)-2-Methoxy-N,N,b-trimethyl-10H-phenothiazine-10-propanamine Levoprom 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-, (.beta.R)- 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (bR)- (9CI) 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (R)- NSC 226516 Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)- (8CI) XP 03 (R)-2-Methoxy-N,N,-trimethyl-10H-phenothiazine-10-propanamine C07192 Methotrimeprazine-d3 maleate Methotrimeprazine (200 mg) 10H-Phenothiazine-10-propanaMine, 2-Methoxy-N,N,β-triMethyl-, (βR)- (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT METHOTRIMEPRAZINE MALEATE SALT (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine (-)-3-(2-Methoxyphenothiazin-10-yl)-2-methylpropyldimethylamine (-)-phenothiazin 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (-)- 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)- 2-Methoxytrimeprazine 3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine 7044 R.P. arc-vi-c-5 bayer1213 CL 36467 CL 39743 cl36467 cl39743 cl53212 dedoran Hirnamin hirnamine Levomeprazine Levomepromazin Levomepromazine Levomepropazine Levopromazine levopromazioni Levoprome Levopromethazine Levotomin Mepromazine methotrimeprazine methoxytrimeprazine milezin minozinan n,beta-trimethyl-2-methoxy-(r)-10h-phenothiazine-10-propanamin Neurocil