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3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine dihydrate structure

CAS No.: 300-39-0

Chemical Name:: 3,5-Diiodo-L-tyrosine dihydrate

Synonyms: (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID

CBNumber:: CB5490149

Molecular Formula:: C9H9I2NO3

Molecular Weight:: 432.98

MDL Number:: MFCD00016542

MOL File:: 300-39-0.mol

Last updated:2023-10-21 13:02:29

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3,5-Diiodo-L-tyrosine dihydrate Properties

Melting point	200 °C (dec.)(lit.)
alpha	-20.7 º (c=2.5, 0.1N NaOH/H2O)
Boiling point	546.5°C (rough estimate)
Density	2.405±0.06 g/cm3(Predicted)
refractive index	1.2 ° (C=5, 1mol/L HCl)
storage temp.	2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly)
form	crystalline
pka	2.12(at 25℃)
color	white
Water Solubility	slightly soluble
Sensitive	Light Sensitive
CAS DataBase Reference	300-39-0(CAS DataBase Reference)
FDA UNII	6L57Q44ZWW
ATC code	H03BX01
NIST Chemistry Reference	3,5-Diiodo-l-tyrosine(300-39-0)
EPA Substance Registry System	L-Tyrosine, 3,5-diiodo- (300-39-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36/37-24/25

RIDADR

2811

WGK Germany

TSCA

Yes

HS Code

29225090

NFPA 704

	0
2		0

3,5-Diiodo-L-tyrosine dihydrate price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	H65420	3,5-Diiodo-L-tyrosine, 95%	300-39-0	25g	$66.5	2021-12-16	Buy
Alfa Aesar	H65420	3,5-Diiodo-L-tyrosine, 95%	300-39-0	100g	$210	2021-12-16	Buy
TRC	D466055	3,5-Diiodo-L-tyrosine	300-39-0	5g	$85	2021-12-16	Buy
TRC	D466055	3,5-Diiodo-L-tyrosine	300-39-0	25g	$185	2021-12-16	Buy
Biosynth Carbosynth	FD46930	3,5-Diiodo-L-tyrosine	300-39-0	500g	$175	2021-12-16	Buy

Product number	Packaging	Price	Buy
H65420	25g	$66.5	Buy
H65420	100g	$210	Buy
D466055	5g	$85	Buy
D466055	25g	$185	Buy
FD46930	500g	$175	Buy

3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Uses,Production

Description

Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.

Chemical Properties

white to beige powder

Uses

3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.

Uses

It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.

Uses

3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Definition

ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.

Synthesis

Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.

Synthesis_300-39-0

Purification Methods

It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

3,5-Diiodo-L-tyrosine dihydrate synthesis

Synthesis of 3,5-Diiodo-L-tyrosine dihydrate from L-Tyrosine

3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials

Raw materials

L-Tyrosine Ammonia Iodine

Preparation Products

L-Thyroxine 3-IODO-L-TYROSINE N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester 4-Hydroxyphenylacetamide METHYL 3,5-DIIODO-L-TYROSINATE

BOC-3,5-DIIODO-L-TYROSINE

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3,5-Diiodo-L-tyrosine dihydrate Suppliers

Global( 299)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025 +8618962125825	sales@ryanchem.com	China	137	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Shanghai Worldyang Chemical Co.,Ltd.	,+86-21-56795779; +8613651600618	sales@worldyachem.com	China	879	58

Supplier	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
GenicBio Limited	58
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shanghai Worldyang Chemical Co.,Ltd.	58

View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-10-21	3,5-Diiodo-L-tyrosine dihydrate 300-39-0	US $20.00-1.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.
2023-10-11	3,5-Diiodo-L-tyrosine dihydrate 300-39-0	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-06	3,5-Diiodo-L-tyrosine dihydrate 300-39-0	US $30.00-10.00 / KG	50KG	99%	500000kg	Hebei Guanlang Biotechnology Co., Ltd.

3,5-Diiodo-L-tyrosine dihydrate
300-39-0
US $20.00-1.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

3,5-Diiodo-L-tyrosine dihydrate
300-39-0
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

3,5-Diiodo-L-tyrosine dihydrate
300-39-0
US $30.00-10.00 / KG
99%
Hebei Guanlang Biotechnology Co., Ltd.

3,5-Diiodo-L-tyrosine dihydrate Spectrum

3,5-Diiodo-L-tyrosine dihydrate(300-39-0)MS 3,5-Diiodo-L-tyrosine dihydrate(300-39-0)¹HNMR 3,5-Diiodo-L-tyrosine dihydrate(300-39-0)IR1 3,5-Diiodo-L-tyrosine dihydrate(300-39-0)IR2

300-39-0(3,5-Diiodo-L-tyrosine dihydrate)Related Search:

Prostratin, PKC activator H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Alanine Boc-D-Tyr-OH L-Tyrosine

2',6'-Pipecoloxylidide 2-Piperidone 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine L-Thyroxine

FMOC-3,5-DIIODO-L-TYROSINE N-Acetyl-3,5-Diiodo-L-tyrosine dihydrate 3 5-DIIODO-L-TYROSINE DIHYDRATE 98%,3 5-DIIODO-L-TYROSINE DIHYDRATE 98 Levothyroxine sodium Sodium levothyroxine

Liothyronine sodium 3,3',5-Triiodo-L-thyronine 3,5-Diiodo-L-thyronine

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3,5-Diiodo-4-hydroxy-β-phenylalanine 3,5-diiodo-l-tyrosin 3,5-Diiodotyrocine 3,5-Iodo-L-tyrosine 3,5-L-Diiodotyrosine 4-Hydroxy-3,5-diiodophenylalanine Tryosine, 3,5-diiodo- Tyrosine, 3,5-diiodo-, L- L-Diiodotyrosine 3,5-Diiodo-L-tyrosine dihydrate,99% 5-Diiodo-L-tyrosinedehydrate L-4-hydroxy-3,5-diiodo-phenylalanine DI-IODO-L-TYROSINE(P) 3,5-Diiodo-L-Tyr-OH 3,7-DibroMo-L-Tyrosine (2S)-2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)propanoic acid H-Tyr(3,5-Di-I)-OH 3,5-Diiodo-L-tyrosinedehydrate 3,5-DIIODO-4-HYDROXY-BETA-PHENYLALANINE 3,5-DIIODINE-L-TYROSINE 3,5-DIIODO-BETA(4-HYDROXYPHENYL)ALANINE 3,5-DIIODO-TYROSINE 4-HYDROXY-3,5-DIIODOPHENYLALANINE, 2-AMINO-3-(4-HYDROXY-3,5-DIIODOPHENYL)PROPIONIC ACID AGONTAN L-TYROSINE, 3,5-DIIODO- DITYRIN H-TYR(3,5-I2)-OH IODOGORGOIC ACID H-3,5-DIIODO-TYR-OH H-L-TYR(3,5-I2)-OH 3,5-Diiodo-beta-(p-hydroxyphenyl)alanine dihydrate H-L-Tyr(3,5-I2)-OH*2H2O 3,5-Diiodo-L-tyrosine dihydrate Liothyronine EP Impurity B 3,5-Diiodo-L-Tyr-OH, 98.5% -tyrosine dihydrate 3,5-Diiodo-L Levofolinate Impurity 2 (Liothyronine EP Impurity B) 3,5-Diiodo-L-tyrosine dihydrate USP/EP/BP 3,5-Diiodo-L-tyrosine dihydrate, BR TIANFU CHEM--3,5-Diiodo-L-tyrosine dihydrate diiodotyrosine L-3,5-DiioDOTyrosine (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid Liothyronine sodium EP Impurity B 3,5-Diiodo-L-tyrosine (Liothyronine Impurity) Liothyronine Impurity 2 (Liothyronine EP Impurity B) DIIODO-L-TYROSINE 300-39-0 C9H9I2NO3x2H2O C9H9I2NO3 C9H912NO3 C9H9I2NO32H2O Biochemicals and Reagents Amino Acids and Peptides BioChemical Modified Amino Acids A - H