ALCLOFENAC
- CAS No.
- 22131-79-9
- Chemical Name:
- ALCLOFENAC
- Synonyms
- Argun;w7320;Epinal;Mervan;W 7320;MY 101;Neosten;Neoston;Zumaril;Reufenac
- CBNumber:
- CB5491171
- Molecular Formula:
- C11H11ClO3
- Molecular Weight:
- 226.66
- MDL Number:
- MFCD00071612
- MOL File:
- 22131-79-9.mol
- MSDS File:
- SDS
| Melting point | 90-91°C |
|---|---|
| Boiling point | 324.6°C (rough estimate) |
| Density | 1.2401 (rough estimate) |
| refractive index | 1.4530 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | pKa 10.3 (Uncertain) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Water Solubility | 13.1mg/L(25 ºC) |
| FDA UNII | M9CP5H21N8 |
| ATC code | M01AB06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin) | |||||||||
| NFPA 704 |
|
ALCLOFENAC price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T100277 | (4-(ALLYLOXY)-3-CHLOROPHENYL)ACETIC ACID Aldrich | 22131-79-9 | 50mg | $179 | 2024-03-01 | Buy |
| TRC | A514550 | Alclofenac | 22131-79-9 | 50mg | $130 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 19416 | Alclofenac | 22131-79-9 | 100mg | $2620 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA17267 | Alclofenac | 22131-79-9 | 250mg | $360 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA17267 | Alclofenac | 22131-79-9 | 500mg | $425 | 2021-12-16 | Buy |
ALCLOFENAC Chemical Properties,Uses,Production
Chemical Properties
Off-White to Pale Yellow Solid
Originator
Allopydin ,Chugai ,Japan ,1976
Uses
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r sh.
Manufacturing Process
103.7 grams of 3-chloro-4-allyloxyphenylacetonitrile in 500 cc of ethanol, 100 grams of potassium hydroxide and 100 cc of water are refluxed for 4 hours. Maximum of alcohol is evaporated, the residue is diluted with water and ice, and acidified with 20% HCl. The solid is filtered and washed with petroleum ether. 91.5 grams of acid are obtained (Yield: 81%) which is recrystallized from aqueous methanol; MP 92-93°C.
brand name
Mervan (Continental Pharma, Belgium);Allopydinac;Alopidin;Alopydin;Argan;Darkeyfenac;Desinflam;Medifenac;Mevan;Mirvan a;Prinalgin;Vanadian;W-7320;Zubirol.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Alclofenac, a phenylacetic acid derivative with analgesic, antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment of rheumatic disorders. In the late 1970s its use was associated with a high incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the withdrawal of the drug, in some cases voluntarily, from several countries. In others registration has been refused. The reported mutagenic potential has been questioned by some investigators and the drug remains on the market in at least three countries with highly evolved regulatory authorities.
Dosage
Alclofenac when used at 3 g/d in the treatment of rheumatoid arthritis is as effective as 75 mg/d of indomethacin with fewer adverse effects. In the treatment of osteoarthritis 1500 mg/d is as effective and is better tolerated than 300 mg/d of phenylbutazone. Alclofenac has been withdrawn from the market in the United Kingdom because of skin rash and vasculitis (blood vessel inflammation).
ALCLOFENAC Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3156 | 55 |
| Struchem Co., Ltd. | 0512-0512-63009836 15365350169 | helen@struchem.com | China | 3989 | 60 |
| Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 | cdhxsj@163.com | China | 14623 | 60 |