HOE-140
- CAS No.
- 138614-30-9
- Chemical Name:
- HOE-140
- Synonyms
- CS-1399;Firazyr;HOE 140 Acetate;lcatibant Acetate;Aldeibant acetate;HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg
- CBNumber:
- CB5497052
- Molecular Formula:
- C59H89N19O13S.C2H4O2
- Molecular Weight:
- 1364.59
- MDL Number:
- MFCD04112967
- MOL File:
- 138614-30-9.mol
- MSDS File:
- SDS
| storage temp. | -20°C |
|---|---|
| solubility |
DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM) Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM) PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM) |
| form | A crystalline solid |
| FDA UNII | 325O8467XK |
HOE-140 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H157 | HOE 140 ≥94% | 138614-30-9 | 250μg | $325 | 2024-03-01 | Buy |
| Cayman Chemical | 24083 | Icatibant (acetate) ≥98% | 138614-30-9 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 24083 | Icatibant (acetate) ≥98% | 138614-30-9 | 1mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 24083 | Icatibant (acetate) ≥98% | 138614-30-9 | 5mg | $435 | 2024-03-01 | Buy |
| TRC | I163750 | IcatibantAcetate | 138614-30-9 | 1mg | $140 | 2021-12-16 | Buy |
HOE-140 Chemical Properties,Uses,Production
Description
Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.
Originator
Jerini (Germany)
Uses
Icatibant Acetate is a bradykinin B2 receptor antagonist that has been recently approved for treatment of acute attacks of hereditary angioedema (HAE).
Uses
Antagonist (bradykinin).
Definition
ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.
brand name
Metastat (CollaGenex);Firazyr.
Biochem/physiol Actions
B2 bradykinin receptors are present in the sensory neurons. Activation of B2 receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B2 bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.
Synthesis
The peptidomimetic is prepared by standard solidphase technology on Wang resin employing Fmoc chemistry. Following trifluoroacetic acid cleavage with appropriate scavengers and HPLC purification, icatibant is ultimately isolated as its acetate salt.
HOE-140 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dorne Chemical Technology co. LTD | +86-13583358881 +86-18560316533 | Ethan@dornechem.com | China | 294 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 1527 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from HOE-140 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | HOE-140
138614-30-9
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD | |
 |
2024-04-12 | HOE-140
138614-30-9
|
US $0.00-0.00 / Box | 1Box | 99 | 50000KG/month | Shanghai Affida new material science and technology center | |
 |
2024-04-12 | HOE-140
138614-30-9
|
US $0.00 / kgkg | 1kgkg | 0.99 | 10T | Shandong Hanjiang Chemical Co., Ltd |
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