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CHLORMETHIAZOLE HYDROCHLORIDE

CAS No.
6001-74-7
Chemical Name:
CHLORMETHIAZOLE HYDROCHLORIDE
Synonyms
Somnevrin hydrochloride;CloMethiazole Hydrochloride;CHLORMETHIAZOLE HYDROCHLORIDE;Clomethiazole hydrochloride salt;Chlormethiazole Hydrochloride >4-methyl-5-(β-chloroethyl)thiazole hydrochloride;Inhibitor,Clomethiazole,Chlormethiazole hydrochloride,Chlormethiazole,inhibit;4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride
CBNumber:
CB5497315
Molecular Formula:
C6H9Cl2NS
Molecular Weight:
198.11336
MDL Number:
MFCD00673948
MOL File:
6001-74-7.mol
MSDS File:
SDS
Last updated:2023-09-20 16:43:00

CHLORMETHIAZOLE HYDROCHLORIDE Properties

Melting point 130℃
storage temp. Desiccate at RT
solubility H2O: >10 mg/mL, soluble
form crystalline
color off-white
Merck 14,2384
Stability Hygroscopic
FDA UNII 85223EMG44

Pharmacokinetic data

Protein binding 65%
Excreted unchanged in urine 0.1-5%
Volume of distribution 4-16(L/kg)
Biological half-life 4 / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H317-H318
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-41-43
Safety Statements  26-36/37/39
WGK Germany  3
HS Code  2934.10.2000
NFPA 704
0
3 0

CHLORMETHIAZOLE HYDROCHLORIDE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1240 Chlormethiazole hydrochloride ≥98% (HPLC), powder 6001-74-7 10mg $57.2 2024-03-01 Buy
Sigma-Aldrich C1240 Chlormethiazole hydrochloride ≥98% (HPLC), powder 6001-74-7 50mg $509 2024-03-01 Buy
TCI Chemical C3020 Chlormethiazole Hydrochloride >98.0%(HPLC)(T) 6001-74-7 200mg $192 2024-03-01 Buy
TCI Chemical C3020 Chlormethiazole Hydrochloride >98.0%(HPLC)(T) 6001-74-7 1g $461 2024-03-01 Buy
TRC C602013 Chlormethiazole hydrochloride 6001-74-7 50mg $215 2021-12-16 Buy
Product number Packaging Price Buy
C1240 10mg $57.2 Buy
C1240 50mg $509 Buy
C3020 200mg $192 Buy
C3020 1g $461 Buy
C602013 50mg $215 Buy

CHLORMETHIAZOLE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Chlormethiazole Hydrochloride was used in the study of effect of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system.

Biochem/physiol Actions

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: enhanced sedative effects.
Antivirals: concentration possibly increased by ritonavir.
Cimetidine: inhibits metabolism of clomethiazole.

Metabolism

Clomethiazole is extensively metabolised, probably by first-pass metabolism in the liver with only small amounts appearing unchanged in the urine. The rate of elimination is decreased by about 30% in liver cirrhosis.

CHLORMETHIAZOLE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
SIMAGCHEM CORP
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TargetMol Chemicals Inc.
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Career Henan Chemica Co
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Nanjing Doge Biomedical Technology Co., Ltd
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LEAPCHEM CO., LTD.
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Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58
Aladdin Scientific
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Mainchem Co., Ltd.
-- sarah@mainchem.com China 6572 58
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24539 81
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@163.com China 284 58

CHLORMETHIAZOLE HYDROCHLORIDE Spectrum

4-methyl-5-(β-chloroethyl)thiazole hydrochloride Somnevrin hydrochloride 4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride CloMethiazole Hydrochloride Clomethiazole hydrochloride salt Chlormethiazole Hydrochloride > Inhibitor,Clomethiazole,Chlormethiazole hydrochloride,Chlormethiazole,inhibit CHLORMETHIAZOLE HYDROCHLORIDE 6001-74-7 C6H8ClNS Heterocycles