Dermorphin
- CAS No.
- 77614-16-5
- Chemical Name:
- Dermorphin
- Synonyms
- DERMORPHIN;Dermorphin HAc;Dermorphin Powder;DERMORPHIN ACETATE;Dermorphin trifluoroacetate salt;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
- CBNumber:
- CB5498044
- Molecular Formula:
- C40H50N8O10
- Molecular Weight:
- 802.87
- MDL Number:
- MFCD00076694
- MOL File:
- 77614-16-5.mol
- MSDS File:
- SDS
| Melting point | 157-159 °C |
|---|---|
| Boiling point | 1323.8±65.0 °C(Predicted) |
| Density | 1.363±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO |
| form | powder |
| pka | 9.83±0.15(Predicted) |
| color | white to off-white |
| Sequence | H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 |
| InChIKey | FHZPGIUBXYVUOY-VWGYHWLBSA-N |
| SMILES | C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1 |
| FDA UNII | 2SEC01B703 |
Dermorphin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J62019 | Dermorphin | 77614-16-5 | 5mg | $194 | 2021-12-16 | Buy |
| ChemScene | CS-7103 | Dermorphin 99.64% | 77614-16-5 | 10mg | $216 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD108711 | Dermorphin | 77614-16-5 | 250mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD108711 | Dermorphin | 77614-16-5 | 500mg | $375 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0001209 | DERMORPHIN 95.00% | 77614-16-5 | 1MG | $427.2 | 2021-12-16 | Buy |
Dermorphin Chemical Properties,Uses,Production
Description
Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors.
Uses
A mu-opioid receptor agonist
Definition
ChEBI: Dermorphin is an oligopeptide.
Side effects
Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].
in vitro
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References
[1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.
Dermorphin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Hebei Weimiao Import and Export Trade Co., Ltd. | +undefined19948166995 | sale01@hbweimiao.com | China | 60 | 58 |
| Hebei Xunou new energy Technology Co., LTD | +undefined17531957005 | xunou8@hbxunou.com | China | 36 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 | admin@china-yime.com | China | 563 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 524 | 58 |
View Lastest Price from Dermorphin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | dermorphin?
77614-16-5
|
US $90.00 / g | 10g | 98% | 20ton | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-19 | dermorphin?
77614-16-5
|
US $60.00-30.00 / box | 1box | 99% | 100000kg | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-19 | DERMORPHIN ACETATE
77614-16-5
|
US $1.00 / g | 1g | 99% | 100kg | Dorne Chemical Technology co. LTD |
-
- dermorphin?
77614-16-5
- US $90.00 / g
- 98%
- Hebei Kangcang new material Technology Co., LTD
-
- dermorphin?
77614-16-5
- US $60.00-30.00 / box
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- DERMORPHIN ACETATE
77614-16-5
- US $1.00 / g
- 99%
- Dorne Chemical Technology co. LTD