SRS16-86
- CAS No.
- 1793052-96-6
- Chemical Name:
- SRS16-86
- Synonyms
- SRS16-86;(Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate;Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester;IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86
- CBNumber:
- CB55540799
- Molecular Formula:
- C26H32N4O2
- Molecular Weight:
- 432.56
- MDL Number:
- MFCD34187226
- MOL File:
- 1793052-96-6.mol
| Boiling point | 614.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| pka | 5.58±0.20(Predicted) |
| color | Yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SRS16-86 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26752 | SRS16-86 | 1793052-96-6 | 1mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 26752 | SRS16-86 | 1793052-96-6 | 5mg | $359 | 2024-03-01 | Buy |
| Cayman Chemical | 26752 | SRS16-86 | 1793052-96-6 | 500μg | $62 | 2024-03-01 | Buy |
| Ambeed | A1490492 | (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate 98+% | 1793052-96-6 | 250mg | $422 | 2021-12-16 | Buy |
| Ambeed | A1490492 | (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate 98+% | 1793052-96-6 | 25mg | $118 | 2021-12-16 | Buy |
SRS16-86 Chemical Properties,Uses,Production
Description
SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2
Definition
ChEBI: SRS16-86 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM. It has a role as a ferroptosis inhibitor. It is a tert-butyl ester, a member of adamantanes, a member of pyrimidines, a substituted aniline, a secondary amino compound and an imine.
References
Linkermann et al. (2014), Synchronized renal tubular cell death involves ferroptosis; Proc. Natl. Acad. Sci. USA. 111 16841 Zhang et al. (2019), Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury; Brain Res. 1706 48
SRS16-86 Preparation Products And Raw materials
Raw materials
Preparation Products
SRS16-86 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3501 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 61720 | 58 |
| Shanghai Hansi Chemical Industry Co., Ltd. | 17717618050 | zllg@gh-reagent.com | China | 10424 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24023 | 58 |