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BAY-985

BAY-985 Structure
BAY-985 structure
CAS No.
2409479-29-2
Chemical Name:
BAY-985
Synonyms
BAY-985;BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor;1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-;(R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one
CBNumber:
CB55839640
Molecular Formula:
C27H30F3N9O
Molecular Weight:
553.58
MDL Number:
MFCD32690108
MOL File:
2409479-29-2.mol
Last updated:2023-05-21 10:59:17
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BAY-985 Properties

Boiling point 753.3±70.0 °C(Predicted)
Density 1.373±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 50 mg/mL (90.32 mM)
form A solid
pka 10.06±0.10(Predicted)

BAY-985 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0112070 BAY-985 99.87% 2409479-29-2 5mg $550 2021-12-16 Buy
ChemScene CS-0112070 BAY-985 99.87% 2409479-29-2 10mg $880 2021-12-16 Buy
ChemScene CS-0112070 BAY-985 99.87% 2409479-29-2 50mg $1950 2021-12-16 Buy
DC Chemicals 012784 BAY-985 2409479-29-2 002 $1500 2021-12-16 Buy
Product number Packaging Price Buy
CS-0112070 5mg $550 Buy
CS-0112070 10mg $880 Buy
CS-0112070 50mg $1950 Buy
012784 002 $1500 Buy

BAY-985 Chemical Properties,Uses,Production

Biological Activity

BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. It is highly potent against TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε (IC50 = 2 nM) and also in mechanocellular phosphorylation of interferon regulatory factor 3 (pIRF3) assays High potency (IC50 = 74 nM) and anti-proliferative effect on SK-MEL-2 cells (IC50 = 900 nM).

in vitro

BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 with IC 50 s of 123, 276, 311, and 7930 nM, respectively.
BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3) with an IC 50 of 74 nM.
BAY-985 is active in cellular mechanistic assay and shows anti-proliferative activity in a few cancer cells lines with IC 50 s of 900 and 7260 nM for SK-MEL2 (NRAS and TP53 mutated) and ACHN (CDKN2A mutated) cells, respectively.

Cell Proliferation Assay

td>
Cell Line: ACHN and SK-MEL-2 cell lines
Concentration:
Incubation Time: 96 hours
Result: Inhibited proliferation i n SK-MEL2 and ACHN cells with IC 50 s of 900 and 7260 nM, respectively.

in vivo

BAY-985 (200 mg/kg; po; bid; 111 days) results in weak antitumor efficacy.
BAY-985 shows high clearance (CL b = 4.0 L/h/kg, ca. 95% hepatic extraction), large volume of distribution at steady state (V ss =2.9 L/kg) and a short terminal half-life (t 1 /2 =0.79 h).

Animal Model: Female NMRI nude mice bearing SK-MEL-2 human melanoma xenograft model
Dosage: 200 mg/kg
Administration: Applied po; twice daily (bid) continuously 111 days
Result: Treatment resulted in weak antitumor efficacy with a T/C tumor weight ratio of 0.6.
The treatment was well tolerated, with a maximum body weight loss of less than 10%.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TBK1
(in high ATP assay)
TargetValue
TBK1
(in low ATP assay)		 2 nM
IKKε
(Cell-free assay)		 2 nM
30 nM
pIRF3
(Cell-free assay)		 74 nM

BAY-985 Preparation Products And Raw materials

Raw materials

Preparation Products

BAY-985 Suppliers

Global( 34)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 278 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9442 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3421 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4121 55
Twochem Co.Ltd 021-58111628 15800915896 sales@twochem.com China 290 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
LEAP CHEM CO., LTD. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Topbiochem Technology Co., Ltd 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Twochem Co.Ltd 55

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BAY-985 1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro- BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor (R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one 2409479-29-2 C27H30F3N9O