ChemicalBook >> CAS DataBase List >>H3B-120
H3B-120
- CAS No.
- 2194903-42-7
- Chemical Name:
- H3B-120
- Synonyms
- H3B-120;N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide;1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-;H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- CBNumber:
- CB56193507
- Molecular Formula:
- C19H24N4O2S
- Molecular Weight:
- 372.48
- MDL Number:
- MFCD32693918
- MOL File:
- 2194903-42-7.mol
Last updated:2023-05-21 10:59:17
H3B-120 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3007 | H3B-120 ≥98% (HPLC) | 2194903-42-7 | 5MG | $94.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3007 | H3B-120 ≥98% (HPLC) | 2194903-42-7 | 25MG | $381 | 2024-03-01 | Buy |
| ChemScene | CS-0119659 | H3B-120 98.45% | 2194903-42-7 | 10mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0119659 | H3B-120 98.45% | 2194903-42-7 | 50mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0119659 | H3B-120 98.45% | 2194903-42-7 | 100mg | $1950 | 2021-12-16 | Buy |
H3B-120 Chemical Properties,Uses,Production
Biological Activity
H3B-120 is a competitive and selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits antitumor activity.
in vitro
H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
It achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
Also H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.
target
| Target | Value | ||||
| CPS1 (Cell-free assay) | 1.4 μM(Ki) | ||||
| CPS1 (Cell-free assay) | 1.5 μM |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3156 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2981 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9445 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 879 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3538 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
H3B-120
N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide
H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-
2194903-42-7