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Foscarnet sodium

Foscarnet sodium
Foscarnet sodium structure
CAS No.
63585-09-1
Chemical Name:
Foscarnet sodium
Synonyms
a29622;Foscavir;Triapten;FOSCARNET;Foscanet sodium;foscarnet sodim;FOSCARNET SODIUM;SODIUM FOSCARNET;Phenytion Sodium;Foscarnet (sodium salt)
CBNumber:
CB5667480
Molecular Formula:
CNa3O5P
Formula Weight:
191.95
MOL File:
63585-09-1.mol

Foscarnet sodium Properties

Melting point:
>250°
storage temp. 
Inert atmosphere,Room Temperature
CAS DataBase Reference
63585-09-1(CAS DataBase Reference)
FDA UNII
964YS0OOG1
NCI Dictionary of Cancer Terms
foscarnet sodium; Foscavir
ATC code
J05AD01
SAFETY
  • Risk and Safety Statements
Toxicity LD50 i.p. in mice: 2000-4000 mmol/kg (Eriksson)

Foscarnet sodium price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1436 Foscarnet Sodium Pharmaceutical Secondary Standard; Certified Reference Material 63585-09-1 1 g $114 2021-03-22 Buy
Sigma-Aldrich 1283302 Foscarnet sodium United States Pharmacopeia (USP) Reference Standard 63585-09-1 50 mg $366 2021-03-22 Buy
Cayman Chemical 20774 Foscarnet (sodium salt) ≥98% 63585-09-1 250mg $33 2021-03-22 Buy
Cayman Chemical 20774 Foscarnet (sodium salt) ≥98% 63585-09-1 500mg $59 2021-03-22 Buy
Cayman Chemical 20774 Foscarnet (sodium salt) ≥98% 63585-09-1 1g $92 2021-03-22 Buy

Foscarnet sodium Chemical Properties,Uses,Production

Description

Foscamet sodium is a new, injectable antiviral agent useful in the treatment of severe cytomegalovirus retinitis in immunodepressed patients. Foscarnet sodium acts by inhibiting viral-specific DNA polymerases; its side-effects include decreased hemoglobin levels and acute tubular necrosis.

Originator

Astra (Sweden)

Uses

Inhibits viral DNA polymerase and reverse transcriptase.
Foscarnet is the only antiviral approved by the FDA for the treatment of acyclovir-resistant HSV infections, a growing problem in the AIDS population. Foscarnet does not require HSV-encoded thymidine kinase. Foscarnet therapy reduces the healing time, pain, and viral shedding. It is administered intravenously, 40 mg/kg every 8 to 12 hours within 7 to 10 days in patients suspected of having acyclovir-resistant herpes simplex infection. Foscarnet is administered for 10 days. Associated side effects include azotemia secondary to nephrotoxicity, hyperphosphatemia, hypocalcemia, anemia, nausea, vomiting, and genital ulceration. Patients may eventually develop resistant strains. Preliminary trials indicate that topical 1%foscarnet cream may have some benefit for the treatment of acyclovir-resistant mucocutaneous HSV infection in patients with AIDS.

Definition

ChEBI: The trisodium salt of phosphonoformic acid. It is used as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who r quire concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Manufacturing Process

423 g (4.77 mol) of sodium hydroxide is added to 400 ml of water. The solution is heated to about 50°C and 167 g (0.795 mol) of triethyl phosphonoformate is added. The reaction mixture is then heated to about 90°C and ethanol formed is distilled off. After about 1 hour at 90-95°C the reaction mixture is cooled to about 20°C and the product is filtered off. The yield of trisodium phosphonoformate hexahydrate wet is 248 g.
The wet substance is recrystallized in 570 ml of water by heating to 423 g (4.77 mol) of sodium hydroxide liquid conc. is added to 400 ml of water. The solution is heated to about 50°C and 167 g (0.795 mol) of triethyl phosphonoformate is added at this temperature. The reaction mixture is then heated to about 90°C and ethanol formed is distilled off. After about 1 hour at 90-95°C the reaction mixture is cooled to about 20°C and the product is filtered off. The yield of trisodium phosphonoformate hexahydrate wet is 248 g.
The wet substance is recrystallized in 570 ml of water by heating to 90°C in order to obtain a clear solution and then cooling to about 20°C. After filtration and washing with 50 ml of water at 18-22°C 187 g (74% of theoretical yield) of trisodium phosphonoformate hexahydrate is obtained. This substance contains about 2% free water, which can be eliminated by drying.

brand name

Foscavir (AstraZeneca).

Therapeutic Function

Antiviral

General Description

pyrophosphateanalog that inhibits replication in herpesviruses(CMV, HSV, and VSV) and retroviruses (HIV).Foscarnet(Foscavir) is taken up slowly by the cells and does not undergosignificant intracellular metabolism. Foscarnet is a reversible,noncompetitive inhibitor at the pyrophosphatebindingsite of the viral DNA polymerase and RT. Theultimate effect is inhibition of the cleavage of pyrophosphatefrom deoxynucleotide triphosphates and a cessation ofthe incorporation of nucleoside triphosphates into DNA(with the concomitant release of pyrophosphate).Becausethe inhibition is noncompetitive with respect to nucleosidetriphosphate binding, foscarnet can act synergistically withnucleoside triphosphate antimetabolites (e.g., zidovudineand didanosine triphosphates) in the inhibition of viral DNAsynthesis. Foscarnet does not require bioactivation by viralor cellular enzymes and, hence, can be effective against resistantviral strains that are deficient in virally encoded nucleosidekinases.
Foscarnet is a second-line drug for the treatment of retinitiscaused by CMV in patients with AIDS. The drug causesmetabolic abnormalities including increases or decreases inblood Ca2 levels. Nephrotoxicity is common, and this sideeffect precludes the use of foscarnet in other infections causedby herpesvirus or as single-agent therapy for HIV infection.Foscarnet is an excellent ligand for metal ion binding,which undoubtedly contributes to the electrolyte imbalancesobserved with the use of the drug.Hypocalcemia, hypomagnesemia,hypokalemia, and hypophosphatemia and hyperphosphatemiaare observed in patients treated with foscarnet.Side effects such as paresthesias, tetani, seizures, and cardiacarrhythmias may result.

Clinical Use

Foscarnet sodium was approved by the U.S. FDA for the treatment of CMV retinitis in patients with AIDS. In combination with ganciclovir, the results have been promising, even in progressive disease with ganciclovir-resistant strains. Foscarnet sodium also is effective in the treatment of mucocutaneous diseases caused by acyclovir-resistant strains of HSV and VZV in patients with AIDS. Foscarnet sodium is administered IV at 60 mg/kg three times a day for initial therapy and at 90 to 120 mg/kg daily for maintenance therapy. The plasma-half life is 3 to 6 hours. Foscarnet sodium penetrates into the CSF and the eye. The drug is neurotoxic, and common adverse effects include phlebitis, anemia, nausea, vomiting, and seizures. Foscarnet sodium carries the risk of severe hypocalcemia, especially with concurrent use of IV pentamidine. Foscarnet sodium used with zidovudine (ZDV) has an additive effect against CMV and acts synergistically against HIV.

Foscarnet sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Foscarnet sodium Suppliers

Global( 194)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20898 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58

View Lastest Price from Foscarnet sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Foscarnet sodium
63585-09-1
US $50.00 / KG 100g 99.99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-09-29 Foscarnet sodium
63585-09-1
US $0.00-0.00 / Kg/Drum 1KG 99%min 500KGS WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-08 Foscarnet sodium
63585-09-1
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

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