4-TRIMETHYLSILYL-3-BUTYN-2-OL
- CAS No.
- 6999-19-5
- Chemical Name:
- 4-TRIMETHYLSILYL-3-BUTYN-2-OL
- Synonyms
- DK369;TIMTEC-BB SBB009027;4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-(Trimethysilyl)-3-butyn-2-ol;1-TRIMETHYLSILYLBUT-1-YNE-3-OL;4-Trimethylsilyl-3-butynol, t;4-(triMethylsilyl)but-3-yn-2-ol;3-Butyn-2-ol, 4-(trimethylsilyl)-;(+/-) 4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-TRIMETHYLSILYL-3-BUTYN-2-OL (+/-)
- CBNumber:
- CB5676325
- Molecular Formula:
- C7H14OSi
- Molecular Weight:
- 142.27
- MDL Number:
- MFCD00190213
- MOL File:
- 6999-19-5.mol
- MSDS File:
- SDS
| Boiling point | 76 °C |
|---|---|
| Density | 0.847 g/mL at 25 °C |
| refractive index |
n |
| Flash point | 143 °F |
| storage temp. | 2-8°C |
| solubility | highly soluble in all standard organic solvents (hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially soluble in water. |
| pka | 13.78±0.20(Predicted) |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| Specific Gravity | 0.846 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1923632 |
| CAS DataBase Reference | 6999-19-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
4-TRIMETHYLSILYL-3-BUTYN-2-OL price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 5g | $45.3 | 2023-06-20 | Buy |
| Sigma-Aldrich | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 25g | $225 | 2023-01-07 | Buy |
| TCI Chemical | T1926 | 4-Trimethylsilyl-3-butyn-2-ol >97.0%(GC) | 6999-19-5 | 5g | $66 | 2024-03-01 | Buy |
| Alfa Aesar | L14815 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 5g | $62.65 | 2024-03-01 | Buy |
| Alfa Aesar | L14815 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 25g | $207.65 | 2024-03-01 | Buy |
4-TRIMETHYLSILYL-3-BUTYN-2-OL Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Physical properties
bp 83–85°C (13 mmHg).
Uses
More recently, Mulzer has reported use of the corresponding
allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis
of the C13–C18 fragment of branimycin (eq 2).
Preparation
racemic 4-trimethylsilyl-3-butyn-2-ol can
be prepared by deprotonation with strong bases (BuLi, LDA,
Grignards reagents) of trimethylsilylacetylene followed
by addition to acetaldehyde.Deprotonation of 3-butyn-2-
ol followed by quenching with excess trimethylsilyl chloride
followed by concomitant hydrolysis of the trimethylsilyl ether
is generally the most straightforward route.Enzymatic reduction
of 4-TMS-3-butyn-2-one has also been used to prepare the
reagent using alcohol dehydrogenase.
Preparation of nonracemic 4-TMS-3-butyn-2-ol has been
accomplished by asymmetric addition of dimethylzinc to
acetaldehyde promoted by TADDOL or addition of a
trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal
elimination of the sulfoxide.Asymmetric reduction of 4-
TMS-3-butyn-2-one using stoichiometric reducing reagents,
catalytic transfer hydrodrogenation,and enzymatic reduction
with isolated protein or whole cells afford the 4-TMS-3-butyn-
2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method
of choice for the large-scale preparation.
4-TRIMETHYLSILYL-3-BUTYN-2-OL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9350 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 | sales@cfmats.com | CHINA | 882 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| Bio Connect Life Sciences | info@bio-connect.nl | United States | 261 | 58 |
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