Formoterol fumarate | 43229-80-7

Formoterol fumarate Properties

Melting point	138-140°C
storage temp.	Room temperature
solubility	Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
pka	pKa1 7.9; pKa2 9.2(at 25℃)
color	White to off-white
λmax	284nm(lit.)
Merck	14,4245
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
FDA UNII	P3T5QA5J9N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H300-H361d-H370-H373-H412
Precautionary statements	P201-P202-P260-P264-P273-P301+P310
RIDADR	3249
RTECS	LQ2988000
HazardClass	6.1(b)
PackingGroup	II
Toxicity	LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida)

Formoterol fumarate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000339	Formoterol for impurity I identification European Pharmacopoeia (EP) Reference Standard	43229-80-7	y0000339	$153	2024-03-01	Buy
Sigma-Aldrich	Y0000340	Formoterol fumarate for system suitability European Pharmacopoeia (EP) Reference Standard	43229-80-7	y0000340	$218	2023-01-07	Buy
Cayman Chemical	15584	Formoterol (hemifumarate) ≥99%	43229-80-7	10mg	$88	2021-12-16	Buy
Cayman Chemical	15584	Formoterol (hemifumarate) ≥99%	43229-80-7	50mg	$352	2021-12-16	Buy
Tocris	1448	Formoterolhemifumarate ≥99%(HPLC)	43229-80-7	10	$162	2021-12-16	Buy

Product number	Packaging	Price	Buy
Y0000339	y0000339	$153	Buy
Y0000340	y0000340	$218	Buy
15584	10mg	$88	Buy
15584	50mg	$352	Buy
1448	10	$162	Buy

Formoterol fumarate Chemical Properties,Uses,Production

Description

Formoterol fumarate is a β2-selective adrenergic agonist useful in the treatment of bronchial asthma. It s potency and duration of action a r e reported to exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.

Chemical Properties

Crystalline Solid

Originator

Yarnanouchi (Japan)

Uses

Formoterol fumarate is a potent β2-AR agonist.

Uses

long-acting β 2-agonist, anti-asthmatic

Uses

A selective 2-adrenergic receptor agonist. Used as an antiasthmatic

Uses

antiasthmatic;?2-agonist

Definition

ChEBI: (S,S)-formoterol fumarate is a fumarate salt prepared from (S,S)-formoterol by reaction of one molecule of fumaric acid for every two molecules of (S,S)-formoterol. It contains a (S,S)-formoterol(1+). It is an enantiomer of an arformoterol fumarate.

brand name

Foradil (Novartis);ATOCK.

Mechanism of action

This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.

Clinical Use

Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.

storage

Store at RT

References

1) Anderson et al. (1993), Formoterol: pharmacology, molecular basis of agonism and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator; Life Sciences, 52 2145 2) Teng et al. (2005), Structure-activity relationship study of novel necroptosis inhibitors; Bioorg. Med. Chem. Lett., 15 5039 3) Noguchi et al. (2015), Effect of beta2-adrenergic agonist on eosinophil adhesion, superoxide anion generation, and degranulation; Allergol. Int., 64 S46 4)Busquets et al. (2004), Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting; Cancer Res., 64 6725 5) O’Neill et al. (2020), Pharmacological targeting of ?2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson’s disease; Br. J. Pharmacol., 177 282

Formoterol fumarate Preparation Products And Raw materials

Raw materials

Preparation Products

Formoterol fumarate Suppliers

Global( 371)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3422	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Formoterol fumarate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-06-26	Formoterol Hemifumarate 43229-80-7	US $200.00 / kg	1kg	99%	1000kg/Month	Hebei Mingeng Biotechnology Co., Ltd
2022-09-01	Formoterol Fumarate 43229-80-7	US $0.00 / kg	1kg	98%min	1-10tons	Changzhou Rokechem Technology Co., Ltd.
2021-11-26	Formoterol fumarate 43229-80-7	US $1.00 / g	100g	99.99%	5ton/Month	Qiuxian Baitai New Material Co., LTD

Formoterol Hemifumarate
43229-80-7
US $200.00 / kg
99%
Hebei Mingeng Biotechnology Co., Ltd

Formoterol Fumarate
43229-80-7
US $0.00 / kg
98%min
Changzhou Rokechem Technology Co., Ltd.

Formoterol fumarate
43229-80-7
US $1.00 / g
99.99%
Qiuxian Baitai New Material Co., LTD

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1,5-Diphenylcarbazide Formoterol fumarate dihydrate Formoterol (N,O-DIBENZYLATED) FORMOTEROL FUMARATE, 98% ( FOR FORMOTEROL FUMARATE ),N,O-DIBENZYLATED FORMOTEROL FUMARATE Formamide

FUMARATE FORMOTEROL FUMARATE FOR SYSTEM SUITABILITY FORMOTEROL FUMARATE HYDRATE

1of4

formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt),dihydrate (+/-)-(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL] FORMAMIDE HEMIFUMARATE (R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE Formoterol fumarate JP13 Formoterol fumarate 50 gram FORMATEROL FUMATATE FORMOTEROL FUMARATE, FOR SYSTEM SUITABILITY EP STANDARD FORMOTEROL FUMARATE, FOR IMPURITY D IDENTIFICATION EP STANDARD FORMOTEROL FUMARATE, EP STANDARD rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Fumarate Dihydrate Formoterol & Formoterol Fumarate FarMeterol ForMaterol FuMarate (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2 ForMoterol FuMarate EP/USP ForMoterol FuMarate Dihydrate API N-(2-hydroxy-5-((S)-1-hydroxy-2-((S)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide hemifumaric acid Formoterol fumarate N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate CGP 25827A Eformoterol fumarate Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt) Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)-, (E)-2-butenedioate (2:1) (salt) Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-, (E)-2-butenedioate (2:1) (salt) NSC 299587 YM 08316 FORMOTEROL FUMARATE n-[2-hydroxy-5-[[(1rs)-1-hydroxy-2-[[(1rs)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (e)-2-butenedioate BD-40A, Atock, Foradil, Oxeze Formoterol dihydrate fumarate Formoterol monohydrate hemifumarate salt, (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (2:1) salt CGP-25827A-e Fumarate dihydrate FORMAMIDE FUMARATE rel-N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide hemifumarate FORADIL;FORMOTEROL N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-(4-methoxyphenyl)-1-methylethyl]-amino]ethyl]phenyl]formamide Formoterol for impurity I identification CRS Formoterol fumarate for system suitability CRS Eformoterol Hemifumarate Formoterol fumarate USP/EP/BP Formoterol Fumarate Anhydrous Formoterol D6 fumarateQ: What is Formoterol D6 fumarate Q: What is the CAS Number of Formoterol D6 fumarate Q: What is the storage condition of Formoterol D6 fumarate Q: What are the applications of Formoterol D6 fumarate Formoterol FumarateQ: What is Formoterol Fumarate Q: What is the CAS Number of Formoterol Fumarate Q: What is the storage condition of Formoterol Fumarate Q: What are the applications of Formoterol Fumarate Formoterol for impurity I identification (Y0000339) Aformoterol FORMOTEROL HEMIFUMARATE Formoterol fumerate dihydrate Formoterol Furoate 43229-80-7 Formoterol Fumarate N-(2-hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide fumarate Sialyllactose Impurity 21 43229-80-7 13229-80-7 2C19H24N2O4C4H4O4 C42H56N4O14