ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
- CAS No.
- Chemical Name:
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
- Synonyms
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40);ANTI-RAT TYROSINE HYDROXYLASE, PHOSPHOSER 40;ANTI-TYROSINE HYDROXYLASE (PSER40) RABBIT PAB;ANTI-TYROSINE HYDROXYLASE, RAT, PHOSPHO-SPECIFIC (SER40), RAT;Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
- CBNumber:
- CB5690172
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03792023
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P305+P351+P338 |
| WGK Germany | 1 |
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T9573 | Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit affinity isolated antibody, aqueous glycerol solution, sufficient for 10?blots | 100μL | $577 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB4503789 | Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit affinity isolated antibody | 100μg | $506 | 2024-03-01 | Buy |
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Chemical Properties,Uses,Production
General Description
Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Biochem/physiol Actions
Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome.
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4175 | 65 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| EMD Biosciences, Inc. | 66 |
| SIGMA-RBI | 91 |
| Chemicon Internatinal, Inc. | 65 |