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N-Boc-tyramine

N-Boc-tyramine structure

CAS No.: 64318-28-1

Chemical Name:: N-Boc-tyramine

Synonyms: BOC-TYRAMINE;Zinc02563753;N-Boc-tyramine;N-Boc-tyramine;N-Boc-4-hydroxyphenethylamine;N-(tert-Butoxycarbonyl)tyramine;N-Boc-2-(4-hydroxyphenyl)ethylamine;N-(tert-Butoxycarbonyl)tyramine >tert-Butyl 4-hydroxyphenethylcarbaMate;4-[2-(N-tert-ButoxycarbonylaMino)ethyl]phenol

CBNumber:: CB5697616

Molecular Formula:: C13H19NO3

Molecular Weight:: 237.29

MDL Number:: MFCD05864730

MOL File:: 64318-28-1.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:06

Product description	Number	Pack Size	Price
N-Boc-tyramine 97%	691550	5g	$211
N-Boc-tyramine 97%	691550	25g	$419
N-(tert-Butoxycarbonyl)tyramine >97.0%(GC)	B3512	5g	$95
N-tert-ButoxycarbonylTyramine	B690580	25g	$310
N-tert-Butoxycarbonyl tyramine	263372	100mg	$406
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N-Boc-tyramine Properties

Melting point	71-75 °C
Boiling point	395.7±25.0 °C(Predicted)
Density	1.100±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	10.01±0.15(Predicted)
form	Solid
color	Off-White to Pale Beige
InChI	InChI=1S/C13H19NO3/c1-13(2,3)17-12(16)14-9-8-10-4-6-11(15)7-5-10/h4-7,15H,8-9H2,1-3H3,(H,14,16)
InChIKey	ILNOTKMMDBWGOK-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NCCC1=CC=C(O)C=C1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

HS Code

2924.29.7790

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

N-Boc-tyramine price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	691550	N-Boc-tyramine 97%	64318-28-1	5g	$211	2025-07-31	Buy
Sigma-Aldrich	691550	N-Boc-tyramine 97%	64318-28-1	25g	$419	2025-07-31	Buy
TCI Chemical	B3512	N-(tert-Butoxycarbonyl)tyramine >97.0%(GC)	64318-28-1	5g	$95	2025-07-31	Buy
TRC	B690580	N-tert-ButoxycarbonylTyramine	64318-28-1	25g	$310	2021-12-16	Buy
Usbiological	263372	N-tert-Butoxycarbonyl tyramine	64318-28-1	100mg	$406	2021-12-16	Buy

Product number	Packaging	Price	Buy
691550	5g	$211	Buy
691550	25g	$419	Buy
B3512	5g	$95	Buy
B690580	25g	$310	Buy
263372	100mg	$406	Buy

N-Boc-tyramine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Intermediate in the preparation of Thyroxin derivatives.

Synthesis

24424-99-5

60-19-5

64318-28-1

a) Synthesis of N-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)ethylamine Tyramine hydrochloride (1.0 g, 5.76 mmol, 1 equiv.) was dissolved in a solvent mixture of dioxane and distilled water (25 mL/12 mL), followed by the addition of 10 mL of aqueous solution of NaOH (0.46 g, 11.5 mmol). After stirring for 10 min, di-tert-butyl dicarbonate (Boc2O) (1.26 g, 5.76 mmol, 1 equiv) was added. The reaction mixture was stirred overnight under argon protection and at room temperature. Upon completion of the reaction, dioxane was removed by evaporation and 40 mL of ethyl acetate (EtOAc) was added to the residual aqueous phase and the pH was adjusted to 7-8 with 1 M HCl solution.The organic and aqueous phases were separated, and the aqueous phase was extracted with EtOAc (2 x 15 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated. The crude product was purified by column chromatography (Al2O3, CH2Cl2/Hex, 85:15) to afford N-(tert-butoxycarbonyl)-2-(4-hydroxyphenyl)ethylamine (0.98 g, 73% yield). Melting point: 61-62°C. IR (KBr, cm-1): 3378.9 (-OH); 1686.6 (C=O). UV-Vis (CH2Cl2, λmax/nm): 277 (ε=1803). 1H-NMR (400 MHz, CDCl3): δ 1.441 (s, 9H, t-Bu); 2.703 (t, J=7.9 Hz, 2H, CH2CH2N); 3.329 (m, 2H, CH2CH2N); 4.602 (br s, 1H, NH or OH); 6.023 (br s, 1H, NH or OH); 6.774 (d, J=8.3 Hz, 2H, ArH); 7.013 (d, J=8.3 Hz, 2H, ArH). 13C-NMR (100 MHz, CDCl3): δ 28.84 (CMe3); 35.64 (CH2CH2N); 42.49 (CH2CH2N); 80.15 (CMe3); 115.97 (Cm); 130.18 (Ci); 130.50 (Cp); 155.38 (Cipso); 156.84 (C=O). Elemental analysis (C13H19NO3, calculated values): C, 65.80%; H, 8.07%; N, 5.90%; measured values: C, 65.77%; H, 8.09%; N, 5.90%. IE MS: m/z 181 [M-(Me)3CO-H+Na]+; 107 [M-(Me)3COC(O)NHCH2]+.

References

[1] Synthesis, 2009, # 22, p. 3838 - 3842
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 23, p. 5877 - 5881
[3] Angew. Chem., 2014, vol. 126, # 23, p. 5987 - 5991,5
[4] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 3, p. 633 - 639
[5] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 15, p. 5496 - 5509

N-Boc-tyramine Preparation Products And Raw materials

Raw materials

Tyramine Di-tert-butyl dicarbonate Tyramine hydrochloride Carbonic acid, bis(1,1-dimethylethyl) ester Hydrochloric acid

Ethyl acetate 1,4-Dioxane Sodium hydroxide Water

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Preparation Products

N-tert-Butoxycarbonyl 3-IodotyraMine N-tert-Butoxycarbonyl 3,5-DiiodotyraMine

N-Boc-tyramine Suppliers

Global( 130)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13822	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9261	58
GL Biochem(Binhai) Ltd.	+86-021-61263370 +8615301650015	wuqiuyan@glschina.com	China	2975	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15082	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Zhengzhou Alfa Chemical Co.,Ltd	58
GL Biochem(Binhai) Ltd.	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from N-Boc-tyramine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-08	N-Boc-tyramine 64318-28-1	US $1.00 / g	1g	99.0%	100kg	Career Henan Chemical Co

N-Boc-tyramine
64318-28-1
US $1.00 / g
99.0%
Career Henan Chemical Co

N-Boc-tyramine Spectrum

N-Boc-tyramine(64318-28-1)¹HNMR

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N-Boc-2-(4-hydroxyphenyl)ethylamine BOC-TYRAMINE N-Boc-tyramine [2-(4-HYDROXY-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER N-(tert-Butoxycarbonyl)tyramine Zinc02563753 4-[2-(N-tert-ButoxycarbonylaMino)ethyl]phenol N-[2-(4-Hydroxyphenyl)ethyl]carbaMic Acid 1,1-DiMethylethyl Ester N-Boc-tyramine N-(tert-Butoxycarbonyl)-4-hydroxyphenethylamine N-Boc-4-hydroxyphenethylamine tert-Butyl 4-hydroxyphenethylcarbaMate tert-butyl N-[2-(4-hydroxyphenyl)ethyl]carbamate N-(tert-Butoxycarbonyl)tyramine > Carbamic acid, N-[2-(4-hydroxyphenyl)ethyl]-, 1,1-dimethylethyl ester N-(tert-Butoxycarbonyl)-4-hydroxyphenethylamine N-Boc-4-hydroxyphenethylamine tert-Butyl [2-(4-Hydroxyphenyl)ethyl]carbamate N-Boc-tyramine 64318-28-1 Aromatics Intermediates & Fine Chemicals Pharmaceuticals Miscellaneous Nitrogen Compounds Organic Building Blocks Protected Amines