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3-Amino-1,2-propanediol

3-Amino-1,2-propanediol Structure
3-Amino-1,2-propanediol structure
CAS No.
616-30-8
Chemical Name:
3-Amino-1,2-propanediol
Synonyms
3-AMINOPROPANE-1,2-DIOL;APD;3-AMINO-1,2-PROPANDIOL;Isoserinol;AMINOPROPANEDIOL;3--1,2-;1-AMINOGLYCEROL;1-aminopropanediol;Glycerol α-monoamine;3-Amino-1,2-propaned
CBNumber:
CB5701843
Molecular Formula:
C3H9NO2
Molecular Weight:
91.11
MDL Number:
MFCD00008140
MOL File:
616-30-8.mol
MSDS File:
SDS
Last updated:2024-01-22 16:43:48
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3-Amino-1,2-propanediol Properties

Melting point 55-57 °C
Boiling point 264-265 °C739 mm Hg(lit.)
Density 1.175 g/mL at 25 °C(lit.)
vapor pressure <1 hPa (20 °C)
refractive index n20/D 1.492(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility >1000g/l soluble
form liquid (highly viscous)
pka 12.11±0.35(Predicted)
Specific Gravity 1.175
color Clear colorless to pale yellow
PH 11 (100g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 1719121
InChIKey KQIGMPWTAHJUMN-UHFFFAOYSA-N
LogP -2.079 (est)
Indirect Additives used in Food Contact Substances 3-AMINO-1,2-PROPANEDIOL
CAS DataBase Reference 616-30-8(CAS DataBase Reference)
FDA UNII RH369P864X
NIST Chemistry Reference 3-Amino-1,2-propanediol(616-30-8)
EPA Substance Registry System 1,2-Propanediol, 3-amino- (616-30-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405
Hazard Codes  C,Xi
Risk Statements  34-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  UN 2735 8/PG 2
WGK Germany  2
RTECS  TY2800000
F  10-21
Hazard Note  Corrosive
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29221980
Toxicity LD50 orally in Rabbit: 7500 mg/kg
NFPA 704
0
3 0

3-Amino-1,2-propanediol price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A76001 (±)-3-Amino-1,2-propanediol 97% 616-30-8 5g $52.5 2024-03-01 Buy
Sigma-Aldrich A76001 (±)-3-Amino-1,2-propanediol 97% 616-30-8 25g $129 2024-03-01 Buy
Sigma-Aldrich 8.18522 3-Amino-1,2-propanediol for synthesis 616-30-8 25mL $92.1 2024-03-01 Buy
TCI Chemical A0628 3-Amino-1,2-propanediol >98.0%(GC)(T) 616-30-8 25g $58 2024-03-01 Buy
Alfa Aesar B22672 (±)-3-Amino-1,2-propanediol, 97% 616-30-8 25g $57.65 2024-03-01 Buy
Product number Packaging Price Buy
A76001 5g $52.5 Buy
A76001 25g $129 Buy
8.18522 25mL $92.1 Buy
A0628 25g $58 Buy
B22672 25g $57.65 Buy

3-Amino-1,2-propanediol Chemical Properties,Uses,Production

Description

3-Amino-1,2-propanediol (APD) is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity.

Chemical Properties

3-Amino-1,2-propanediol is a very viscous transparent colorless to pale yellow liquid with a melting point of 55-57 °C and a boiling point of 264-265 °C. The density at 25 °C is 1.175 g/mL. soluble in water.

Originator

Henkel (W. Germany)

Uses

3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials.

Application

3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. It is also used in the synthesis of Decarbazolyl Carvedilol (D212720), a metabolite of Carvedilol (C184625) found in humans, rats, dogs and mice.

Preparation

3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps.

Application

3-Amino-1,2-propanediol is used as a chiral selector ligand, used subsequently for a nucleophilic substitution with the dimethoxytrityl (DMT)-protected.

brand name

Aminomux

General Description

3-Amino-1,2-propanediol is a chiral glycerol derivative. It could used as a hydrogen bond donor in the design of a new deep eutectic solvent which have emerged as a suitable alternative to VOCs (volatile organic compounds) for diverse practical applications including, among others, drug delivery, electrochemistry, material design, extractions and, of course, organic reactions, alone or together twith other sustainable reaction-media[1]. It can also used as a core present in antiviral compounds to skeleton to design a novel class of anti-adenovirus agents[2].

Hazard

3-Amino-1,2-propanediol is Danger.
H314 (93.33%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H318 (56.36%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.

storage

3-Amino-1,2-propanediol absorbs moisture and needs to be kept in a container sealed. Store in cool, dry conditions in well-sealed containers.

References

[1] Antenucci A, et al. Design of a New Chiral Deep Eutectic Solvent Based on 3-Amino-1,2-propanediol and Its Application in Organolithium Chemistry. Molecules, 2022; 27.
[2] Mazzotta S, et al. Design, synthesis and in vitro biological evaluation of a novel class of anti-adenovirus agents based on 3-amino-1,2-propanediol. Bioorganic Chemistry, 2021; 114: 105095.

3-Amino-1,2-propanediol Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Potassium hydroxide Methanol 3-Chloro-1,2-propanediol Epichlorohydrin

Preparation Products

3-Amino-1,2-propanediol Suppliers

Global( 492)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Hebei Guanlang Biotechnology Co,.LTD 		+8619930503252 daisy@crovellbio.com China 5964 58
Firsky International Trade (Wuhan) Co., Ltd 		+8615387054039 admin@firsky-cn.com China 436 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+86-028-64841719 +8618980456393 daisy@enlaibio.com China 1369 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7786 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Guanlang Biotechnology Co,.LTD 		58
Firsky International Trade (Wuhan) Co., Ltd 		58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60

Related articles

View Lastest Price from 3-Amino-1,2-propanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Amino-1,2-propanediol pictures 2024-04-24 3-Amino-1,2-propanediol
616-30-8
 US $0.00-0.00 / kg 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
3-Amino-1,2-Propanediol pictures 2024-01-22 3-Amino-1,2-Propanediol
616-30-8
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
3-Amino-1,2-propanediol pictures 2023-10-08 3-Amino-1,2-propanediol
616-30-8
 US $30.00 / L 1L 99% 20T Firsky International Trade (Wuhan) Co., Ltd

3-Amino-1,2-propanediol Spectrum

3-Amino-1,2-propanediol(616-30-8)MS3-Amino-1,2-propanediol(616-30-8)13CNMR3-Amino-1,2-propanediol(616-30-8)IR13-Amino-1,2-propanediol(616-30-8)Raman

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3-AMino-1,2-propanediol, 98% 25GR 3-AMINO-1,2-PROPANEDIOL FOR SYNTHESIS 3 - aMino - 1, 2 - propylene glycol 3-AMINO-1,2-DIHYDROXYPROPANE (+/-)-3-AMINO-1,2-PROPANEDIOL 3-AMINO-1,2-PROPANEDIOL 2,3-DIHYDROXY-1-PROPYLAMINE 1-AMINO-2,3-PROPANDIOL 1-AMINO-2,3-PROPANEDIOL 1-AMINOGLYCEROL 1,2-DIHYDROXY-3-AMINOPROPANE 1,2-DIHYDROXY-1-PROPYLAMINE 1,2-Propanediol, 3-amino- 1-aminopropanediol 2,3-Dihydroxypropylamine 2,3-Propandiol-1-amine 3-amino-2-propanediol (+/-)-3-AMINO-1,2-PROPANEEDIOL 3-AMINO-1,2-PROOPANEDIOL 3-Aminopropane-1,2-diol 99% 3-AMINO-1,2-PROPANEDIOL 98% Aminopropylene glycol 1-Amino-2,3-dihydroxypropane Glycerol α-monoamine 3-Amino-1,2-propanediol,98% 3-Amino-1,2-propanediol (Isoserinol) 3-Amino-1,2-propaned 3-AMNIO-1,2-PROPANEDIOL 3-AMino-1,2-propanediol, 98% 100GR 3-Amino-1,2-propanediol USP/EP/BP 3-AMINO-1,2-PROPANDIOL Isoserinol 3-AMINOPROPANE-1,2-DIOL AMINOPROPANEDIOL APD (+/-)-3-AMINO-1,2-PROPANEDIOL 3-amino-1,2-propanediol (APD) 1-Aminopropan-2,3-diol Ethyl Acetate Impurity 32 3--1,2- 616-30-8 NH2CH2CHOHCH2OH AMINE Oxygen Compounds Organic Building Blocks Amino Alcohols Building Blocks API Alcohols and Derivatives Amino Alcohols Organic Building Blocks Oxygen Compounds 616-30-8