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Cloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt Structure
Cloxacillin-13C4 SodiuM Salt structure
CAS No.
642-78-4
Chemical Name:
Cloxacillin-13C4 SodiuM Salt
Synonyms
cloxapen;Sodium cloxacillin;Cloxacillin sodium salt;CLOXACILLIN SODIUM SALT HYDRATE;3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt;5R;(2S;2-DPPE;Orbenin;tegopen
CBNumber:
CB5705412
Molecular Formula:
C19H19ClN3NaO5S
Molecular Weight:
459.88
MDL Number:
MFCD00150735
MOL File:
642-78-4.mol
MSDS File:
SDS
Last updated:2024-04-07 18:44:46
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Cloxacillin-13C4 SodiuM Salt Properties

Melting point 170°C
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, colorless
form Solid
color White to Off-White
Water Solubility Soluble in water
BCS Class 3
Stability Stable. Incompatible with strong oxidizing agents. Refrigerate.
CAS DataBase Reference 642-78-4(CAS DataBase Reference)
FDA UNII MWQ645MKMF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Hazard Codes  Xn
Risk Statements  36/37/38-42/43
Safety Statements  26-36-22
WGK Germany  2
RTECS  XH8920000
NFPA 704
0
2 0

Cloxacillin-13C4 SodiuM Salt price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 27555 Cloxacillin sodium salt ≥95.0% (HPLC) 642-78-4 1G $67.2 2023-06-20 Buy
Sigma-Aldrich 27555 Cloxacillin sodium salt ≥95.0% (HPLC) 642-78-4 5G $270 2023-06-20 Buy
Alfa Aesar J64314 Cloxacillin sodium salt 642-78-4 1g $51.65 2024-03-01 Buy
Alfa Aesar J64314 Cloxacillin sodium salt 642-78-4 5g $148.65 2024-03-01 Buy
Cayman Chemical 22249 Cloxacillin (sodium salt) ≥95% 642-78-4 5g $73 2024-03-01 Buy
Product number Packaging Price Buy
27555 1G $67.2 Buy
27555 5G $270 Buy
J64314 1g $51.65 Buy
J64314 5g $148.65 Buy
22249 5g $73 Buy

Cloxacillin-13C4 SodiuM Salt Chemical Properties,Uses,Production

Description

Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.

Chemical Properties

White Crystalline Powder

Originator

Orbenin,Beecham,UK,1962

Uses

Ropivacaine (R675000) metabolite.

Uses

Labelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.

Uses

Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.

Uses

Cloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.

Definition

ChEBI: Cloxacillin sodium is an organic sodium salt. It contains a cloxacillin(1-).

Manufacturing Process

The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.
The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.

brand name

Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).

Therapeutic Function

Antibacterial

Purification Methods

Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}

Cloxacillin-13C4 SodiuM Salt Preparation Products And Raw materials

Raw materials

6-Aminopenicillanic acid Ethyl acetoacetate

Preparation Products

Sodium cloxacillin monohydrate

Cloxacillin-13C4 SodiuM Salt Suppliers

Global( 243)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-13474506593 +86-13474506593 sarah@tnjone.com China 794 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8615821988213 info@longyupharma.com China 2531 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Shaanxi Dideu Medichem Co. Ltd 		18192627656 1012@dideu.com China 3657 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17367 58
Supplier Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
SIMAGCHEM CORP 		58

View Lastest Price from Cloxacillin-13C4 SodiuM Salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cloxacillin Sodium pictures 2024-04-07 Cloxacillin Sodium
642-78-4
 US $0.00 / kg 1kg 99% 1000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Cloxacillin-13C4 SodiuM Salt pictures 2023-03-29 Cloxacillin-13C4 SodiuM Salt
642-78-4
 US $50.00 / kg 1kg 99% 20 tons Hebei Duling International Trade Co. LTD
Cloxacillin Sodium pictures 2023-03-06 Cloxacillin Sodium
642-78-4
 US $10.50 / KG 1KG 99 1 ton Hebei Guanlang Biotechnology Co,.LTD

642-78-4(Cloxacillin-13C4 SodiuM Salt)Related Search:

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Fenoxaprop-p-ethyl Chlorodimethylphenylsilane Flucloxacillin sodium

1of4

CLOXACILLIN SODIUM SALT MONOHYDRATE CLOXACILLIN SODIUM SALT N-HYDRATE [5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE 4-Acetyloxy-N-despropyl Ropivacaine (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid SodiuM Salt (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid-13C4 SodiuM Salt 3-(o-Chlorophenyl)-5-Methyl-4-isoxazolylpenicillin-13C Cloxacillin-13C4 SodiuM Salt (S)-(-)-Dropropizine-d4 3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-monosodiumsalt 3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillinsodium ankerbin brl-1621sodiumsalt ekvacillin gelstaph monosodiumcloxacillin orbeninsodium prevencilinap prostaphilina 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, monosodium salt (8CI) Orbenin Sodium 3-(O-chlorophenyl)-5-methyl-4-isoxazolylpenicillin SODIUMCLOXACILLIN(ANHYDROUS) (2S (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt 5R CLOXACILLINSODIUMPOWDER/COMPACTED/STERILELYOPHILED (2S,5R)-6α-[[[3-(2-Chlorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid sodium salt Cloxacillin sodium anhydrous austrastaph prostaphlina sodiumorbenin sodiumsyntarpen staphybiotic syntarpensodiumsalt tegopen Thiazole sodium chloride 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)- sodium 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]-oxomethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Cloxacillin-13C4 SodiuM Salt USP/EP/BP Cloxacillin-13C4 Sodium SaltQ: What is Cloxacillin-13C4 Sodium Salt Q: What is the CAS Number of Cloxacillin-13C4 Sodium Salt 4S)-Sacubitril 2-Dipalmitoyl-sn-glycero-3-PE 2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine 2-DPPE CLOXACILLIN SODIUM SALT HYDRATE cloxapen 3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt Cloxacillin sodium salt Sodium cloxacillin Oxacillin Impurity 5 Sodium Salt (Cloxacillin Sodium Salt) Phenylbutazone Impurity 30 Oxacillin Impurity 17 Sodium Salt 642-78-4 C19H17ClN3NaO5S C19H18ClN3O5SNa