Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Neferine

Neferine

Neferine Structure
Neferine structure
CAS No.
2292-16-2
Chemical Name:
Neferine
Synonyms
Neferin;NEFERINE;Methylliensinine;Neferine USP/EP/BP;4''-O-Methylliensinine;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol
CBNumber:
CB5706015
Molecular Formula:
C38H44N2O6
Molecular Weight:
624.77
MDL Number:
MFCD01707128
MOL File:
2292-16-2.mol
Last updated:2023-08-24 17:20:48
Request For Quotation

Neferine Properties

Melting point 59-61 °C
Boiling point 710.9±60.0 °C(Predicted)
Density 1.185±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >15mg/mL
form powder
pka 9.28±0.45(Predicted)
color white to beige
optical activity [α]/D -34 to -44° (c=0 3. CHCl3)
InChIKey MIBATSHDJRIUJK-ROJLCIKYSA-N

SAFETY

Risk and Safety Statements

WGK Germany  3
RTECS  SM9495000

Neferine price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0349 Neferine ≥98% (HPLC) 2292-16-2 5mg $113 2024-03-01 Buy
Sigma-Aldrich SML0349 Neferine ≥98% (HPLC) 2292-16-2 25mg $441 2024-03-01 Buy
Usbiological 300672 Neferine 2292-16-2 20mg $490 2021-12-16 Buy
TRC N389200 Neferine 2292-16-2 5mg $220 2021-12-16 Buy
ChemScene CS-5848 Neferine 99.92% 2292-16-2 25mg $170 2021-12-16 Buy
Product number Packaging Price Buy
SML0349 5mg $113 Buy
SML0349 25mg $441 Buy
300672 20mg $490 Buy
N389200 5mg $220 Buy
CS-5848 25mg $170 Buy

Neferine Chemical Properties,Uses,Production

Description

A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.

Uses

Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.

Definition

ChEBI: Neferine is a member of isoquinolines.

Biochem/physiol Actions

Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.

References

Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)

Neferine Preparation Products And Raw materials

Raw materials

Preparation Products

Neferine Suppliers

Global( 193)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd. 		+8618080483897 sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953 sales@pioneerbiotech.com China 3000 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanghai Standard Technology Co., Ltd. 		18502101150 ft-sales@nature-standard.com CHINA 1923 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Supplier Advantage
Shaanxi Haibo Biotechnology Co., Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
Chengdu GLP biotechnology Co Ltd 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Shaanxi Pioneer Biotech Co., Ltd . 		58
BOC Sciences 		58
Shanghai Standard Technology Co., Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58

View Lastest Price from Neferine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Neferine pictures 2024-04-12 Neferine
2292-16-2
 US $0.00 / kg 1kg 99% 2000ton Shaanxi Haibo Biotechnology Co., Ltd
Neferine pictures 2023-02-24 Neferine
2292-16-2
 US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
Neferine pictures 2020-01-19 Neferine
2292-16-2
 US $3.00 / KG 1KG 98% 1kg,5kg,50kg Career Henan Chemical Co
  • Neferine pictures
  • Neferine
    2292-16-2
  • US $0.00 / kg
  • 99%
  • Shaanxi Haibo Biotechnology Co., Ltd
  • Neferine pictures
  • Neferine
    2292-16-2
  • US $0.00 / mg
  • ≥98%(HPLC)
  • Shanghai Standard Technology Co., Ltd.
  • Neferine pictures
  • Neferine
    2292-16-2
  • US $3.00 / KG
  • 98%
  • Career Henan Chemical Co

Neferine Spectrum

Neferine(2292-16-2)1HNMR

2292-16-2(Neferine)Related Search:

Vincristine 13,14-Didehydromatridin-15-one Hydroxytyrosol Vincristine sulfate Aloe emodin
Kresoxim-methyl Liensinine Thiophanate-methyl Bensulfuron methyl Methyl acetate
Methylparaben METSULFURON METHYL Methyl acrylate Methyl Parathion-methyl
Methyl bromide Isoliensinine Neferine

1of4

Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]- 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol 4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol Neferin NEFERINE 4''-O-Methylliensinine Methylliensinine 4-[[(1r)-6,7-dimethoxy-2-methyl-3,4-dihydro-1h-isoquinolin-1-yl]methyl]-2-[[(1r)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1h-isoquinolin-7-yl]oxy]phenol Neferine USP/EP/BP 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol 4-(((S)-6,7-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol 2292-16-2 reference standards from Chinese medicinal herbs (TCM). standardized herbal extract chemical reagent pharmaceutical intermediate phytochemical