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Famotidine

Description Reference
Famotidine
Famotidine structure
CAS No.
76824-35-6
Chemical Name:
Famotidine
Synonyms
ganor;mk208;Ifada;gaster;motiax;muclox;pepcid;pepdul;peptan;fibonel
CBNumber:
CB5706585
Molecular Formula:
C8H15N7O2S3
Formula Weight:
337.45
MOL File:
76824-35-6.mol

Famotidine Properties

Melting point:
163-164°C
Density 
1.5111 (rough estimate)
refractive index 
1.7400 (estimate)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Very slightly soluble in water, freely soluble in glacial acetic acid, very slightly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. It dissolves in dilute mineral acids
form 
neat
pka
pKa 6.76(H2O t=23.0) (Uncertain)
Water Solubility 
1.1 mg/mL
InChIKey
XUFQPHANEAPEMJ-UHFFFAOYSA-N
CAS DataBase Reference
76824-35-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  20/21/22-45-61
Safety Statements  22-24/25-53-45-36/37/39
WGK Germany  2
RTECS  UA2300000
HS Code  29341000
Hazardous Substances Data 76824-35-6(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 244.4 mg/kg (Yasufumi)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Precautionary statements:

Famotidine price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F6889 Famotidine 76824-35-6 1g $123 2018-11-13 Buy
Sigma-Aldrich 1269200 Famotidine United States Pharmacopeia (USP) Reference Standard 76824-35-6 125mg $280 2018-11-13 Buy
TCI Chemical F0530 Famotidine >98.0%(T) 76824-35-6 5g $117 2018-11-22 Buy
TCI Chemical F0530 Famotidine >98.0%(T) 76824-35-6 25g $396 2018-11-22 Buy
Alfa Aesar J63165 Famotidine, 98+% 76824-35-6 5g $169 2018-11-15 Buy

Famotidine Chemical Properties,Uses,Production

Description

Famotidine (Chemical formula: C8H15N7O2S3; Brand Name: PEPCID) belongs to a histamine H2-receptor antagonist. It appears as a white to pale yellow crystalline compound. Inside the body, its primary activity is inhibiting the gastric secretion process, further reducing the acid concentration and volume of gastric secretion in the stomach. Based on this property, it is used for the treatment and prevention of ulcers occurring in the stomach and intestines. It can also treat diseases such as Zollinger-Ellison syndrome in which the stomach accumulates excess amount of acids. Moreover, it is also applied during the treatment of gastroesophageal reflux disease (GERD) and pathological hypersecretory conditions.

Reference

http://www.rxlist.com/pepcid-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Famotidine

Description

Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both in prescription and over-the-counter forms. It is used to treat conditions related to the oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions that occur when stomach acid is secreted/ produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison syndrome’.

Chemical Properties

White Powder

Originator

Yamauouchi (Japan)

Uses

Histamine H2-receptor antagonist. Antiulcerative.

Uses

antiinflammatory

Uses

For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).

Uses

Use as an H2-antagonist. An anti-ulcer agent

brand name

Fluxid (Schwarz Pharma); Pepcid (Merck);Amifatidine;Famodil;Pepsidac;GASTER.

Contact allergens

Contact dermatitis in a nurse from famotidine, an H2-receptor agonist, was described. In industry, three cases were reported due to intermediates of the synthesis of 2-diamino-ethylene-amino-thiazolyl-methylenethio urea-dichloride, and 4-chloromethyl-2-guanidinothiaz ole-nitrochloride.

Clinical Use

Famotidine is a histamine H2-antagonist more potent than cimetidine and ranitidine. Administered once or twice daily, it is useful in the treatment of gastric, duodenal and anastomotic ulcers, upper gastrointestinal tract hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome. Like ranitidine, it is lacking in antiandrogenic effects.

Famotidine Preparation Products And Raw materials

Raw materials

Preparation Products


Famotidine Suppliers

Global( 242)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 277 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20229 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 140 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4558 58

View Lastest Price from Famotidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-31 Famotidine
76824-35-6
US $100.00 / KG 1KG 98% 100KG career henan chemical co
2018-04-27 famotidine Skype : honestcooperation
76824-35-6
US $1.00 / KG 1KG 99%min in stock Whatsapp: 008617197824289 Hebei Jiangkai Trading Co., Ltd

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