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Calcium dobesilate

Calcium dobesilate
Calcium dobesilate structure
Chemical Name:
Calcium dobesilate
205-E;doxium;dexium;Calciumdobesilat;CALCIUM DOBESILATE;5-benzenesulfonate;calcium dihydroxy-2;Qiangbenhuangsuangai;CALCIUMDOBESILATECAPSULE;Caium Dobesilate Mnohydrate
Molecular Formula:
Formula Weight:
MOL File:

Calcium dobesilate Properties

Melting point:
>300° (dec)
storage temp. 
Inert atmosphere,Room Temperature
H2O: soluble15mg/mL, clear
white to beige
CAS DataBase Reference
20123-80-2(CAS DataBase Reference)
ATC code
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
HazardClass  IRRITANT
Toxicity LD50 in mice: 700 mg/kg (Esteve-Subirana)

Calcium dobesilate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0488 Dobesilate Calcium ≥98% (HPLC) 20123-80-2 10mg $59.2 2021-12-16 Buy
Sigma-Aldrich SML0488 Dobesilate Calcium ≥98% (HPLC) 20123-80-2 50mg $240 2021-12-16 Buy
Biosynth Carbosynth FC40877 Calcium dobesilate monohydrate 20123-80-2 2 g $280 2021-12-16 Buy
Biosynth Carbosynth FC40877 Calcium dobesilate monohydrate 20123-80-2 5 g $600 2021-12-16 Buy
American Custom Chemicals Corporation API0010514 2,5-DIHYDROXY-BENZENESULFONIC ACID, CALCIUM SALT (2:1) 95.00% 20123-80-2 500MG $637.5 2021-12-16 Buy

Calcium dobesilate Chemical Properties,Uses,Production


Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.

Chemical Properties

White or almost white, hygroscopic powder.




Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.


Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.


Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.
Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).

Manufacturing Process

To an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.

Therapeutic Function


General Description

Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.

Biochem/physiol Actions

Dobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.

Side effects

Skin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)

Mode of action

Calcium dobesilate is a vaosactive drug used in the management of diabetic retinopathy and venous insufficiency. Calcium dobesilate's mechanism of action is thought to be related to decreasing tissue edema by altering vascular permeability and platelet aggregation. Mentes and colleagues randomized 29 patients with symptomatic hemorrhoids to calcium dobesilate and a high-fiber diet or to a highfiber diet alone. Eighty-six percent of patients treated with calcium dobesilate described cessation of bleeding and improvement in perianal irritation.

Calcium dobesilate synthesis

Synthesis of Calcium dobesilate from 2,5-dihydroxybenzenesulphonic acid

Calcium dobesilate Preparation Products And Raw materials

Raw materials

Preparation Products

Calcium dobesilate Suppliers

Global( 272)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22607 55
+86-571-8723 8903
+86-571-87063838 CHINA 997 58
career henan chemical co
+86-0371-55982848 China 29953 58
+86 18953170293
+86 0531-67809011 CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
Shaanxi Dideu Medichem Co. Ltd
029-88380327 CHINA 3979 58

View Lastest Price from Calcium dobesilate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-12 Calcium dobesilate
US $0.00 / Kg/Drum 1KG 99% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-12-01 Calcium Dobesilate
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-11-30 Calcium dobesilate
US $78.00 / KG 25KG 98% 1-10mt Baoji Guokang Bio-Technology Co., Ltd.

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