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4-Fluorobenzylamine

CAS No.
140-75-0
Chemical Name:
4-Fluorobenzylamine
Synonyms
(4-Fluorophenyl)methanamine;P-FLUOROBENZYLAMINE;Benzylamine, p-fluoro-;NSC 158269;AURORA KA-7685;P-flubenzylamine;AKOS BBS-00003618;4-FLUOROBENZYLAMINE;RARECHEM AL BW 0026;4-fluro benzylamine
CBNumber:
CB5716902
Molecular Formula:
C7H8FN
Molecular Weight:
125.14
MDL Number:
MFCD00008120
MOL File:
140-75-0.mol
MSDS File:
SDS
Last updated:2023-04-27 16:27:43

4-Fluorobenzylamine Properties

Melting point 183 °C
Boiling point 183 °C (lit.)
Density 1.095 g/mL at 25 °C (lit.)
refractive index n20/D 1.512(lit.)
Flash point 152 °F
storage temp. Keep in dark place,Inert atmosphere,2-8°C
form Liquid
pka 9.01±0.10(Predicted)
color Clear colorless to light yellow
Specific Gravity 1.101.095
Water Solubility Soluble in water.
Sensitive Air Sensitive
BRN 636501
InChIKey IIFVWLUQBAIPMJ-UHFFFAOYSA-N
CAS DataBase Reference 140-75-0(CAS DataBase Reference)
NIST Chemistry Reference Benzenemethanamine, 4-fluoro-(140-75-0)
EPA Substance Registry System Benzenemethanamine, 4-fluoro- (140-75-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H290-H314
Precautionary statements  P234-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C,Xi
Risk Statements  34-20/21/22
Safety Statements  26-27-36/37/39-45-36/39
RIDADR  UN 2735 8/PG 2
WGK Germany  3
10-34
Hazard Note  Irritant
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29214980
NFPA 704
2
3 0

4-Fluorobenzylamine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 162493 4-Fluorobenzylamine 97% 140-75-0 5g $36.4 2024-03-01 Buy
Sigma-Aldrich 162493 4-Fluorobenzylamine 97% 140-75-0 25g $70 2024-03-01 Buy
TCI Chemical F0252 4-Fluorobenzylamine >98.0%(GC) 140-75-0 5g $38 2024-03-01 Buy
TCI Chemical F0252 4-Fluorobenzylamine >98.0%(GC) 140-75-0 25g $56 2024-03-01 Buy
Alfa Aesar A15486 4-Fluorobenzylamine, 98+% 140-75-0 10g $31.65 2024-03-01 Buy
Product number Packaging Price Buy
162493 5g $36.4 Buy
162493 25g $70 Buy
F0252 5g $38 Buy
F0252 25g $56 Buy
A15486 10g $31.65 Buy

4-Fluorobenzylamine Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liquid.

Uses

4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.

General Description

[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds.

Synthesis

In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.

318-49-0
140-75-0
Synthesis of 4-Fluorobenzylamine from N-(p-fluorobenzyl)phthalimide
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View Lastest Price from 4-Fluorobenzylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Fluorobenzylamine pictures 2024-04-25 4-Fluorobenzylamine
140-75-0
US $10.00-150.00 / kg 1kg NLT98% 2 ton per month Anhui Dexinjia Biopharm Co., Ltd
4-Fluorobenzylamine pictures 2023-03-06 4-Fluorobenzylamine
140-75-0
US $20.00 / kg 1kg 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
4-Fluorobenzylamine pictures 2023-01-31 4-Fluorobenzylamine
140-75-0
US $50.00 / KG 1KG 99% 20tons Hebei Mojin Biotechnology Co., Ltd
4-Fluorobenzylamine ,99% 4-FluorobenzylaMine, 97% 25GR p-FluorobenzeneMethanaMine 4-FLUOROBENZYLAMINE FOR SYNTHESIS 4-FluorobenzylaMine0.99 4-fluoro-benzenemethanamin RARECHEM AL BW 0026 4- fluorinebenzyl aMine The fluorine benzylaMine 4-FLUOROBENZYLAMINE AKOS BBS-00003618 LABOTEST-BB LTBB000702 AURORA KA-7685 4-fluoroBenzenemethanamine 4-FLUOROBENZYLAMINE, 97+% Para Fluorobenzyamine Benzenemethanamine, 4-fluoro- 4-Fluorobenzylamine 98% 4-FLUOROBENZYLAMINE 98+% [(4-Fluorophenyl)methyl]amine 1-(4-Fluorophenyl)methanamine NSC 158269 Flupirtine Impurity J 4-Fluorobenzylamine> 4-fluro benzylamine 4-Fluorobenzylamine ISO 9001:2015 REACH 4-Fluorobenzylamine extrapure, 99% (4-Fluorophenyl)methanamine Benzylamine, p-fluoro- P-FLUOROBENZYLAMINE Glimepiride Impurity 39 Hydrochloride P-flubenzylamine 140-75-0 C7H5FN Nitrogen Compounds Organic Building Blocks C7 Amines Building Blocks Anilines, Aromatic Amines and Nitro Compounds Amines Aromatics Amine C7 Nitrogen Compounds fine chemicals bc0001 john's