2'-Hydroxypropiophenone
- CAS No.
- 610-99-1
- Chemical Name:
- 2'-Hydroxypropiophenone
- Synonyms
- 2-Propionylphenol;o-Propiophenol;2'-hydroxy acetone;o-Hydroxylpropioph;2'-Hydroxypropiophen;2-HYDROXYNITROBENZENE;O-HYDROXYPROPIOPHENONE;2-HYDROXYPROPIOPHENONE;2'-HYDROXYPROPIOPHENONE;o-Hydroxylpropiophenone
- CBNumber:
- CB5717338
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MDL Number:
- MFCD00002220
- MOL File:
- 610-99-1.mol
- MSDS File:
- SDS
| Melting point | 20-22 °C |
|---|---|
| Boiling point | 115 °C15 mm Hg(lit.) |
| Density | 1.094 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 8.33±0.35(Predicted) |
| color | Colourless |
| BRN | 1860264 |
| LogP | 2.540 |
| CAS DataBase Reference | 610-99-1(CAS DataBase Reference) |
| FDA UNII | ZGH9CA1BFI |
| NIST Chemistry Reference | ortho-Hydroxypropiophenone(610-99-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
2'-Hydroxypropiophenone price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H55103 | 2′-Hydroxypropiophenone 97% | 610-99-1 | 25g | $62.4 | 2024-03-01 | Buy |
| TCI Chemical | H0298 | 2'-Hydroxypropiophenone >97.0%(GC) | 610-99-1 | 25g | $39 | 2024-03-01 | Buy |
| TRC | H996363 | 2''-Hydroxypropiophenone | 610-99-1 | 1g | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0021063 | 2'-HYDROXY PROPIOPHENONE 95.00% | 610-99-1 | 25G | $1129.92 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0021063 | 2'-HYDROXY PROPIOPHENONE 95.00% | 610-99-1 | 5G | $815.93 | 2021-12-16 | Buy |
2'-Hydroxypropiophenone Chemical Properties,Uses,Production
Chemical Properties
CLEAR BROWNISH LIQUID
Definition
ChEBI: 2'-hydroxypropiophenone is an aromatic ketone.
Preparation
Obtained by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ?, then at 130–150° for 2–3 h after solvent elimination (32–35%)
with aluminium chloride in chlorobenzene using microwave irradiation for 3 ? min at 106° (28%)
with aluminium chloride in nitrobenzene at 50° for 18 h (16%) or at ? 20° for 48 h (10%)
with aluminium chloride in nitromethane at 20° for 7 days (20%)
with aluminium chloride in heptane at 80–90° for 7 h (53%) or in tetrachlo-? roethane at 95° for 5 h (43%)
with aluminium chloride without solvent at 250° for 5 min or at 180–200° for ? 15 min (76–78%), at 140–160° (32–35%), at 140°
with zirconium chloride in o-dichlorobenzene at 120° for 3 h (83%)
with titanium tetrachloride in o-dichlorobenzene at 150° for 1 h (62%) ?, in nitromethane at 20° for 7 days (13%) or without solvent at 50° for 10 h (30%)
with titanium tetrabromide in o-dichlorobenzene at 150° for 1 h (60%)
with stannic chloride at 50° for 3 h (25%)
with boron trifluoride at 120–135° for 15 min (15%)
with zinc chloride at 180–200° for 15 min (10%)
with polyphosphoric acid at 100° (13%)
Also obtained by Friedel–Crafts acylation of phenol with propionyl chloride in the presence of aluminium chloride (40%), at 120–130° for 1 h (45%) according to the method
Also obtained by acylation of phenol with propionic acid
in the presence of boron trifluoride at 165° for 1 h (45%) or at 80° for ? 2 h (8%)
in the presence of polyphosphoric acid at 100° for 10 min (by-product)
in the presence of zinc chloride at 160° for 1 h
Also obtained by isomerization of 4-hydroxypropiophenone with aluminium chloride (1.5 equiv) at 165° for 1 h (40%) or at 180–200° for 15 min (55%)
Also obtained by demethylation of 2-propionylanisole with fuming hydrochloric acid (d = 1.19) in a sealed tube at 110° for 6 h
Also obtained (by-product) by heating 3-tert-butyl-4-hydroxypropiophenone with aluminium chloride at 170° for 15 min (13%)
Also obtained by treatment of 2,3-dimethylchromone with sodium ethoxide in boiling ethanol for 30 h according to the method
Also obtained from 2-allylphenol by treatment with perbenzoic acid in ethyl ether, first at 0°, then between 0° and 25° for 24 h (78%)
Also obtained by reaction of 2-bromophenyl propionate in a ethyl ether/hexane/THF mixture at low temperature (?78 to ?95°) with sec-butyllithium to give, after hydrolysis, the titled ketone (metal-promoted Fries rearrangement) (17%)
Also obtained by reaction of ethylmagnesium bromide
with 2-hydroxybenzamide in boiling benzene, followed by hydrolysis ? (30%)
with 2-hydroxy-N,N-diethylbenzamide in boiling benzene, followed by ? hydrolysis (82–84%)
Also isolated by heating of 1-(o-hydroxyphenyl)cyclopropyltrimethylam-monium iodide for 1 h at 140° with 1.5 equiv of N,N-diisopropylethylamine (not water-free) (38%)
Also obtained by hydrolysis of 2-(1-methyliminopropyl)phenol (4aa) with aqueous acetic acid/THF at 40° for 4 h (86%)
Also obtained by photolysis of phenyl propionate in water or in solution containing b-cyclodextrine (254 nm) at 25° for 2 h
Also obtained by treatment of 2-(1-hydroxypropyl)phenol with MnO2 in methylene chloride for 7 h at r.t.
2'-Hydroxypropiophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from 2'-Hydroxypropiophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-08 | 2'-Hydroxypropiophenone
610-99-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2022-10-11 | 2'-Hydroxypropiophenone
610-99-1
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2021-08-31 | 2'-Hydroxypropiophenone
610-99-1
|
US $10.00 / KG | 1KG | 99.99% | 20 tons/month | Wuhan Monad Medicine Tech Co.,LTD |
-
- 2'-Hydroxypropiophenone
610-99-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 2'-Hydroxypropiophenone
610-99-1
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- 2'-Hydroxypropiophenone
610-99-1
- US $10.00 / KG
- 99.99%
- Wuhan Monad Medicine Tech Co.,LTD