EGS Crosslinker
- CAS No.
- 70539-42-3
- Chemical Name:
- EGS Crosslinker
- Synonyms
- EGS;EGNHS;HI-EFF-2B;LAC-4R-886;EGS Crosslinker;ethyleneglycolylbis(succinimidylsuccinate;Ethlene glycol bis(succinimidyl succinate);ETHYLENE GLYCOL BIS(SUCCINIMIDYL SUCCINATE);DI(N-SUCCINIMIDYL) ETHYLENE GLYCOL DISUCCINATE;Ethylene glycol bis(succiniMidylsuccinate)(EGS)
- CBNumber:
- CB5722624
- Molecular Formula:
- C18H20N2O12
- Molecular Weight:
- 456.36
- MDL Number:
- MFCD00049057
- MOL File:
- 70539-42-3.mol
| Boiling point | 603.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | acetic acid: water (1:1): ≤50mg/mL |
| form | powder |
| BRN | 9167119 |
| InChI | InChI=1S/C18H20N2O12/c21-11-1-2-12(22)19(11)31-17(27)7-5-15(25)29-9-10-30-16(26)6-8-18(28)32-20-13(23)3-4-14(20)24/h1-10H2 |
| InChIKey | QLHLYJHNOCILIT-UHFFFAOYSA-N |
| SMILES | O(N1C(CCC1=O)=O)C(=O)CCC(=O)OCCOC(=O)CCC(=O)ON1C(CCC1=O)=O |
| FDA UNII | FZX9NM7QE4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29280000 |
EGS Crosslinker price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E3257 | Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) powder | 70539-42-3 | 250mg | $166 | 2024-03-01 | Buy |
| Sigma-Aldrich | E3257 | Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) powder | 70539-42-3 | 1g | $498 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CHM0014396 | ETHYLENE GLYCOLBIS(SUCCINIMIDYLSUCCINATE) 95.00% | 70539-42-3 | 1G | $708.48 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK359030 | Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) 95% | 70539-42-3 | 50mg | $39 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK359030 | Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) 95% | 70539-42-3 | 250mg | $126 | 2021-12-16 | Buy |
EGS Crosslinker Chemical Properties,Uses,Production
Description
EGS Crosslinker is a cleavable crosslinker which can be cleaved using hydroxyamine. EGS Crosslinkers contain two NHS ester groups which can react with primary amines.
Uses
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is commonly used as a crosslinker in chemical reactions. It is a homobifunctional crosslinking reagent that is reactive with bromoacetate amines and sulfhydryls.
Biochem/physiol Actions
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) is a homobifunctional, cleavable cross-linking reagent. It is mainly coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer.
Properties and Applications
EGS crosslinker, Ethylene glycolbis(succinimidyl succinate), is a water-insoluble homobifunctional crosslinker that must be dissolved in DMSO or DMF before addition to an aqueous reaction. EGS crosslinking takes place through amine-reactive NHS esters at both ends of a 16.1-angstrom spacer arm. The 12-atom spacer arm of the EGS crosslinking reagent is cleavable and the spacer arm is cleaved by hydroxylamine at pH 8.5 for 3-6 hours at 37°C. The EGS protein crosslinker possesses amino reactive NHS esters on both ends of the molecule and can be used to label intracellular proteins since the molecule is cell membrane permeable. EGS crosslinker is often used in ChIP assays to determine DNA-protein binding interactions. The directly water-soluble analog of EGS is Sulfo-EGS.
EGS Crosslinker Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hongxiong | +undefined18915499068 | Suzhouhongxiong@163.com | China | 120 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5988 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from EGS Crosslinker manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-07 | Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester)
70539-42-3
|
US $0.00 / G | 1G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2022-09-24 | EGS
70539-42-3
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-07-13 | EGS
70539-42-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Ethyleneglycol-bis(succinicacidN-hydroxysuccinimideester)
70539-42-3
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- EGS
70539-42-3
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- EGS
70539-42-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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