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CALCIFEDIOL

Description Therapeutic drug for bone disease Side effects and precautions References
CALCIFEDIOL
CALCIFEDIOL structure
CAS No.
19356-17-3
Chemical Name:
CALCIFEDIOL
Synonyms
Didrogyl;U-32070E;CALCIDIOL;Ro 8-8892;Hidroferol;Calcifediol;Rovimix Hy-D;Calcifediol, >=98%;25-HYDROXYVITAMIN D3;Calcifediol anhydrous
CBNumber:
CB5727250
Molecular Formula:
C27H44O2
Formula Weight:
400.64
MOL File:
19356-17-3.mol

CALCIFEDIOL Properties

Melting point:
74-76oC
Boiling point:
529.2±33.0 °C(Predicted)
Density 
1.01±0.1 g/cm3(Predicted)
Flash point:
14 °C
storage temp. 
−20°C
form 
White to off-white crystalline solid.
pka
14.74±0.20(Predicted)
InChIKey
JWUBBDSIWDLEOM-DTOXIADCSA-N
FDA UNII
T0WXW8F54E
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H319-H301+H311-H330-H372
Precautionary statements  P210-P280-P305+P351+P338-P337+P313-P403+P235-P260-P284-P301+P310-P310
Hazard Codes  T+,F
Risk Statements  28-48/25-26-24/25-11
Safety Statements  28-36/37-45-16-7
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
8-10-19
HazardClass  6.1
PackingGroup 
HS Code  29362900

CALCIFEDIOL price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 739642 25-Hydroxyvitamin D 50 μg/mL in ethanol, 98% (CP) 19356-17-3 1ml $195 2019-12-02 Buy
Sigma-Aldrich 739650 25-Hydroxyvitamin D 100 μg/mL in ethanol, 98% (CP) 19356-17-3 1ml $195 2019-12-02 Buy
Cayman Chemical 9000683 25-hydroxy Vitamin D3 ≥98% 19356-17-3 1mg $65 2018-11-19 Buy
Cayman Chemical 9000683 25-hydroxy Vitamin D3 ≥98% 19356-17-3 5mg $293 2018-11-19 Buy
Sigma-Aldrich 739669 25-Hydroxyvitamin D 5 μg/mL in ethanol, 98% (CP) 19356-17-3 1ml $195 2019-12-02 Buy

CALCIFEDIOL Chemical Properties,Uses,Production

Description

Calcifediol (synonym 25-Hydroxyvitamin D3) is a vitamin D analog and the major metabolite of vitamin D3 (Cholecalciferol) in the liver. Its main function is the regulation of calcium and phosphorus, which is necessary for strong bones. It is used to treat patients with serious kidney diseases to decrease the parathyroid hormone (PTH) level. It is used to treat rickets and osteomalacia, both in azotemic and non-azotemic patient. Calcifediol is sold under RAYALDEE® to treat secondary hyperparathyroidism associated with vitamin D insufficiency in stage 3-4 chronic kidney disease.

Therapeutic drug for bone disease

The natural source of Vitamin D in the body depends on ultraviolet rays of sunlight, making the 7-dehydrocholesterol convert into vitamin D3, at first under the action of vitamin D3 hydroxylase in liver vitamin D3 converts into the Calcifediol, vitamin D3 mainly is present in the form of the Calcifediol in the blood, in the kidney the Calcifediol is further converted to 1,25-dihydroxyvitamin D3 (calcitriol for short) and 24,25-dihydroxyvitamin D3, activity of calcitriol is 2-5 times of the Calcifediol, the two drugs can promote bone re-absorption of calcium and intestinal absorption of Ca2 +. In addition to regulating the body's calcium and phosphorus metabolism, this product can promote the intestinal absorption of calcium and phosphorus, promote calcium and phosphorus deposits in the bone tissue, promote bone formation.
Calcifediol itself has a certain activity, can be used for the treatment of metabolic bone diseases, such as osteoporosis, rickets, osteomalacia, but also for hemodialysis-induced hypocalcemia. Patients with chronic renal failure combined with metabolic bone diseases, engaged during dialysis, can be applied. It can increase the levels of serum calcium, can reduce levels of serum alkaline phosphatase and parathyroid hormone, improve radiological and histological sign of osteitis (with or without osteomalacia). Bone resorption, hyperparathyroidism and osteodystrophy signs of mineralization defects all can be reduced, as for osteomalacia patients and children who are unable to obtain sufficient bone development because of renal osteodystrophy or parathyroid dysfunction, may be more favorable than calcitriol. Such cases can be treated with Calcifediol and calcitriol. But as for osteomalacia accompanied by gastrointestinal diseases, Calcifediol is preferable. If because of liver disease to cause generated obstacles of 25-OHD in vivo, secondary osteomalacia, can also try to use this product. But osteomalacia caused by aluminum poisoning, treatment of vitamin D preparations often is ineffective. Chelator deferoxamine (Desferal) clear aluminum of blood dialysis, can be effective.
Osteomalacia and rickets (in children causing deformities severe osteomalacia) is characterized by obstacle of bone mineralization and non-calcified bone-like tissue or cartilage accumulation. Bone changes of Vitamin D-related bone softening, accompanied with normal or reduced levels of serum calcium and phosphorus, increased serum alkaline phosphatase, and PTH is secondary increased.
Osteoporosis is characterized by reduced bone tissue thereby increasing the likelihood of fractures. Pathological mechanism may be an increased rate of bone resorption, exceeding bone formation; or decreased bone formation, and bone resorption is also still normal or reduced. Bone is progressive missing, can compress and collapse the spine, causing pain, body shorter and kyphosis. Patients are also prone to the outer periphery fracture.
The above information is edited by the chemicalbook of Liu Yujie.

Side effects and precautions

Like all the vitamin D metabolites, excessive Calcifediol can also cause increased serum calcium, in urine can increase high. Therefore, in the dose adjustment period, serum calcium should be monitored at least once a week, if increased serum calcium was found, it should be discontinued.
Pregnant women use this product, there is no adequately controlled studies, but in experimental animals, teratogenic effects have been found.
The US Food and Drug Administration (FDA) classify the product into pregnancy category C drugs.
People who use digitalis, should be used with caution vitamin D, because increased calcium may induce arrhythmia.
Other side effects and precautions, see "Vitamin D2" (Vita-min D2) that is ergocalciferol.
Action of Vitamin D2 is intense, may cause damage. Increased serum calcium caused by excess, can cause gastrointestinal and central nervous system lesions, soft tissue calcification. Kidney complications can be very serious and even cause death. Such as increased serum calcium persists, after discontinuation, kidney damage likely will continue for a long time. An individual who the amount is not too large, but also because of increased sensitivity to occur adverse reactions.
Calcifediol is rapidly absorbed, at 4 to 8 hours up to serum peak concentration. Transport shall bind with protein, half-life is about 16 days.

References

  1. https://pubchem.ncbi.nlm.nih.gov
  2. https://de.wikipedia.org/wiki/Calcidiol
  3. https://www.webmd.com
  4. https://www.drugbank.ca

Chemical Properties

White Solid

Uses

A metabolite of Vitamin D. The principal circulating form of vitamin D3, formed in the liver by hydroxylation at C-25. Calcium regulator.

Definition

ChEBI: A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of v tamin D3.

brand name

Calderol (Organon).

CALCIFEDIOL Preparation Products And Raw materials

Raw materials

Preparation Products


CALCIFEDIOL Suppliers

Global( 140)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21826 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10217 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35436 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7496 58

View Lastest Price from CALCIFEDIOL manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-10-15 Calcifediol CAS NO.19356-17-3 CAS NO.19356-17-3
19356-17-3
US $1.00 / G 100G 99.9% 50000 tons Hebei Ruishun Trade Co.,Ltd
2020-01-02 CALCIFEDIOL
19356-17-3
US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

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