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2'-C-Methylcytidine

2'-C-Methylcytidine structure

CAS No.: 20724-73-6

Chemical Name:: 2'-C-Methylcytidine

Synonyms: NM-107;CS-2055;-C-Methylcytidine;2''-METHYLCYTIDINE;2'-C-METHYLCYTIDINE;2'-CMethyl-D-cytidine;2’-β-C-Methylcytidine;Cytidine, 2'-C-methyl-;2’-b-C-Methyl cytidine;2'-C-Methylcytidine USP/EP/BP

CBNumber:: CB5732016

Molecular Formula:: C10H15N3O5

Molecular Weight:: 257.24

MDL Number:: MFCD02682947

MOL File:: 20724-73-6.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:52

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2'-C-Methylcytidine Properties

Melting point	243-245°C
Boiling point	523.9±60.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	H2O: >20mg/mL
pka	13.53±0.70(Predicted)
form	powder
color	white to off-white
InChIKey	PPUDLEUZKVJXSZ-VPCXQMTMSA-N
FDA UNII	27FS20C1D8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

NFPA 704

	0
2		0

2'-C-Methylcytidine price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M4949	2’-C-Methylcytidine ≥95% (HPLC), powder	20724-73-6	5mg	$97.9	2024-03-01	Buy
Sigma-Aldrich	M4949	2’-C-Methylcytidine ≥95% (HPLC), powder	20724-73-6	25mg	$388	2024-03-01	Buy
Cayman Chemical	22887	2'-C-Methylcytidine ≥98%	20724-73-6	5mg	$86	2024-03-01	Buy
Cayman Chemical	22887	2'-C-Methylcytidine ≥98%	20724-73-6	10mg	$161	2024-03-01	Buy
Cayman Chemical	22887	2'-C-Methylcytidine ≥98%	20724-73-6	25mg	$336	2024-03-01	Buy

Product number	Packaging	Price	Buy
M4949	5mg	$97.9	Buy
M4949	25mg	$388	Buy
22887	5mg	$86	Buy
22887	10mg	$161	Buy
22887	25mg	$336	Buy

2'-C-Methylcytidine Chemical Properties,Uses,Production

Description

2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC₅₀ values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC₅₀ = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC₅₀ = 2.2 μM) and human coronavirus (HCoV; EC₅₀ = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC₅₀ = 6.4 μM) and swine vesicular disease virus (SVDV; EC₅₀ = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.

Chemical Properties

White to Off-White Powder

Uses

2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

2'-C-Methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-C-Methylcytidine Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10027	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58

Supplier	Advantage
NewCan Biotech Limited	58
career henan chemical co	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from 2'-C-Methylcytidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-06	2'-C-Methylcytidine 20724-73-6	US $5.00 / KG	1KG	99%	1ton	Career Henan Chemical Co

2'-C-Methylcytidine
20724-73-6
US $5.00 / KG
99%
Career Henan Chemical Co

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2'-C-Methylcytidine

1of4

2'-C-METHYLCYTIDINE 2'-CMethyl-D-cytidine 2''-METHYLCYTIDINE 1-(2-C-Methyl-β-D-ribofuranosyl)cytosine NM-107 2'-C-Methyl-1-β-D-ribofuranosylcytosine -C-Methylcytidine 2'-C-METHYLCYTIDINE;NM-107;VALOPICITABINE CS-2055 4-AMINO-1-[3,4-DIHYDROXY-5-(HYDROXYMETHYL)-3-METHYLOXOLAN-2-YL]PYRIMIDIN-2-ONE Cytidine, 2'-C-methyl- 2’-C-Methyl cytidine, 2’-C-Methyl-1-β-D-ribofuranosyl cytosine 2’-β-C-Methylcytidine 2'-C-Methylcytidine USP/EP/BP 4-Amino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 2’-b-C-Methyl cytidine NM107, HCV drug 2’-b-C-Methyl cytidine 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one NM 107,inhibit,Inhibitor,HCV,Hepatitis C virus,NM107 20724-73-6 C10H15N3O5 Bases & Related Reagents Nucleotides