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2,2,2-Trifluoroethanol

Description Chemical properties Uses Preparation method Hazards & Safety Information
2,2,2-Trifluoroethanol
2,2,2-Trifluoroethanol structure
CAS No.
75-89-8
Chemical Name:
2,2,2-Trifluoroethanol
Synonyms
TFE;TFEA ;TFETOH;TFE/TFEA;CF3CH2OH;Fluorinol 85;2,2,2-Trifluor;TRIFLUOROETHANOL;Trifluoroethanol1;Trifluoroethanol2
CBNumber:
CB5736665
Molecular Formula:
C2H3F3O
Formula Weight:
100.04
MOL File:
75-89-8.mol

2,2,2-Trifluoroethanol Properties

Melting point:
−44 °C(lit.)
Boiling point:
77-80 °C(lit.)
Density 
1.391 g/mL at 20 °C
vapor density 
3.5 (vs air)
vapor pressure 
70 mm Hg ( 25 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
85 °F
storage temp. 
Store at RT.
pka
12.4(at 25℃)
form 
Liquid
color 
Clear colorless
Specific Gravity
1.373
explosive limit
8.4-28.8%(V)
Water Solubility 
Miscible with water, ethers, ketones, alcohols and chloroform.
λmax
λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 
14,9682
BRN 
1733203
Stability:
Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.
CAS DataBase Reference
75-89-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanol, 2,2,2-trifluoro-(75-89-8)
EPA Substance Registry System
Ethanol, 2,2,2-trifluoro-(75-89-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F
Risk Statements  10-20/21/22-37/38-41-62-38-36/37/38
Safety Statements  26-36-39-45-36/37/39-16
RIDADR  UN 1986 3/PG 3
WGK Germany  1
RTECS  KM5250000
Autoignition Temperature ~896 °F
Hazard Note  Flammable/Toxic
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29055910
Toxicity LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

2,2,2-Trifluoroethanol price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 91683 2,2,2-Trifluoroethanol analytical standard, for NMR spectroscopy 75-89-8 25ml $95.7 2018-11-13 Buy
Sigma-Aldrich 91683 2,2,2-Trifluoroethanol analytical standard, for NMR spectroscopy 75-89-8 100ml $350 2018-11-13 Buy
TCI Chemical T0435 2,2,2-Trifluoroethanol >99.0%(GC) 75-89-8 25g $16 2018-11-22 Buy
TCI Chemical T0435 2,2,2-Trifluoroethanol >99.0%(GC) 75-89-8 100g $36 2018-11-22 Buy
Alfa Aesar A10788 2,2,2-Trifluoroethanol, 99+% 75-89-8 100g $36.6 2018-11-13 Buy

2,2,2-Trifluoroethanol Chemical Properties,Uses,Production

Description

2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis.
The main use of trifluoroethanol is as anesthetic, at the earliest, fluorine acetylene ether which synthesized by trifluoroethanol and acetylene takes place of bigger side effects of bromine-fluoro alkanes as anesthetic, and then trichloroethanol is used as raw material to develop non-flammable, low toxicity isoflurane alkanes and high performance of the new anesthetic of chlorofluoroalkane. Trifluoroethanol can be introduced into drug structure as trifluoromethyl of functional group, it can generate significant physiological activity, increase fat-soluble of molecules, improve efficacy or reduce side effects of the organism, its synthetic drugs have central nervous system stimulants fluticasone Seoul, substituted pyridines stomach cytoplasmic proton pump inhibitor Lansoprazole and Pariprazole, antiarrhythmic drugs flecainide with amines and analgesic drugs benzodiazepines and dysuria treatment KMD-3212 and so on.

Chemical properties

Boiling point is 73.6℃, melting point is-43.5℃, refractive index is 1.2940, density (25 ℃) is 1.383g/cm3, enthalpy of evaporation is 37.8kJ/mol.

Uses

(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl).
(2) It can be used for chemical reagents.
(3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates.
(4) It can be used as solvent, it is also used as medicine, pesticide intermediates.

Preparation method

Since 1933 Swarts used trifluoroacetic anhydride as raw material, catalytic reduction method was used to get trichloroethanol, we have developed a series of synthetic methods. According to the type, the reaction can be divided into three kinds: oxidation, reduction and hydrolysis. According to raw material, it can be divided trifluoroacetic acid method, trifluoroacetyl chloride method, trifluoroacetic anhydride method, trifluoroacetate law, trifluoroacetic acetaldehyde, polyvinylidene fluoride method, trifluoroethane (HFC-143a) method and trifluoro chloroethane (HCFC-133a) method.

Hazards & Safety Information

Category: Flammable liquid
Toxicity grading: highly toxic
Acute oral toxicity-rat LD50: 240 mg/kg; Oral-Mouse LD50: 366 mg/kg
Irritation data: Skin-Rabbit 0.75 mg/24 hours and severe; Eyes-rabbit 20 mg/24 hr mild
Flammability hazard characteristics: When meets fire, heat, oxidants, it is flammable; it can burn and generate toxic fluoride fumes.
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Chemical Properties

Colorless liquid

Uses

In synthesis of medical anaesthetics, pharmaceuticals, and agrochemicals; in polymerizations. Protein denaturant; stabilizes peptide structures. Cleaning solvent; eluent in HPLC separations; working fluid in Rankine heat cycle systems. Environmentally friendly alternative to CFCs.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dry it with CaSO4 and a little NaHCO3 (to remove traces of acid) and distil it. Highly TOXIC vapour. [Beilstein 1 IV 1370.]

2,2,2-Trifluoroethanol Preparation Products And Raw materials

Raw materials

Preparation Products


2,2,2-Trifluoroethanol Suppliers

Global( 316)Suppliers
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Capot Chemical Co.,Ltd.
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+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
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Mainchem Co., Ltd.
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career henan chemical co
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Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
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View Lastest Price from 2,2,2-Trifluoroethanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-16 2,2,2-Trifluoroethanol
75-89-8
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-12-16 2,2,2-Trifluoroethanol
75-89-8
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-12-16 2,2,2-Trifluoroethanol
75-89-8
US $7.00 / kg 1kg 99% 100kg career henan chemical co

2,2,2-Trifluoroethanol Spectrum


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