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2,2,2-Trifluoroethanol

2,2,2-Trifluoroethanol Structure
2,2,2-Trifluoroethanol structure
CAS No.
75-89-8
Chemical Name:
2,2,2-Trifluoroethanol
Synonyms
TFE;CF3CH2OH;TRIFLUOROETHANOL;2,2,2-TRIFLUROETHANOL;TFETOH;2,2,2-Trifluoroethan;2,2,2-Trifluorethanol;2,2,2-Trifluoroethyl alcohol;TFEA;TFE/TFEA
CBNumber:
CB5736665
Molecular Formula:
C2H3F3O
Lewis structure
cf3ch2oh lewis structure
Molecular Weight:
100.04
MDL Number:
MFCD00004672
MOL File:
75-89-8.mol
MSDS File:
SDS
Last updated:2023-11-28 16:31:44
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2,2,2-Trifluoroethanol Properties

Melting point −44 °C(lit.)
Boiling point 77-80 °C(lit.)
Density 1.391 g/mL at 20 °C
vapor density 3.5 (vs air)
vapor pressure 70 mm Hg ( 25 °C)
refractive index n20/D 1.3(lit.)
Flash point 85 °F
storage temp. Store below +30°C.
solubility soluble in Chloroform, Methanol
form Liquid
pka 12.4(at 25℃)
color Clear colorless
Specific Gravity 1.373
Odor Alcoholic odour
PH Range 5-7 (10% aq soln)
explosive limit 8.4-28.8%(V)
Viscosity 1.75 cP @ 20°C
Water Solubility Miscible with water, ethers, ketones, alcohols and chloroform.
λmax λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02
Merck 14,9682
BRN 1733203
Dielectric constant 8.5500000000000007
Stability Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.
InChIKey RHQDFWAXVIIEBN-UHFFFAOYSA-N
CAS DataBase Reference 75-89-8(CAS DataBase Reference)
FDA UNII 8T8I76KYF1
NIST Chemistry Reference Ethanol, 2,2,2-trifluoro-(75-89-8)
EPA Substance Registry System 2,2,2-Trifluoroethanol (75-89-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H301+H331-H318-H360F-H373
Precautionary statements  P201-P210-P280-P301+P310-P304+P340+P311-P305+P351+P338
Hazard Codes  Xn,T,F
Risk Statements  10-20/21/22-37/38-41-62-38-36/37/38
Safety Statements  26-36-39-45-36/37/39-16
RIDADR  UN 1986 3/PG 3
WGK Germany  1
RTECS  KM5250000
Autoignition Temperature ~896 °F
Hazard Note  Flammable/Toxic
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29055910
Toxicity LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg
NFPA 704
2
3 0

2,2,2-Trifluoroethanol price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 91683 2,2,2-Trifluoroethanol analytical standard, for NMR spectroscopy 75-89-8 25ml $133 2024-03-01 Buy
Sigma-Aldrich 8.08259 2,2,2-Trifluoroethanol for synthesis 75-89-8 100mL $62.1 2024-03-01 Buy
Sigma-Aldrich 91683 2,2,2-Trifluoroethanol analytical standard, for NMR spectroscopy 75-89-8 100ml $490 2024-03-01 Buy
Sigma-Aldrich 8.08259 2,2,2-Trifluoroethanol for synthesis 75-89-8 250ML $144 2024-03-01 Buy
Sigma-Aldrich 8.08259 2,2,2-Trifluoroethanol for synthesis 75-89-8 1L $357 2024-03-01 Buy
Product number Packaging Price Buy
91683 25ml $133 Buy
8.08259 100mL $62.1 Buy
91683 100ml $490 Buy
8.08259 250ML $144 Buy
8.08259 1L $357 Buy

2,2,2-Trifluoroethanol Chemical Properties,Uses,Production

Description

2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis.
The main use of trifluoroethanol is as anesthetic, at the earliest, fluorine acetylene ether which synthesized by trifluoroethanol and acetylene takes place of bigger side effects of bromine-fluoro alkanes as anesthetic, and then trichloroethanol is used as raw material to develop non-flammable, low toxicity isoflurane alkanes and high performance of the new anesthetic of chlorofluoroalkane. Trifluoroethanol can be introduced into drug structure as trifluoromethyl of functional group, it can generate significant physiological activity, increase fat-soluble of molecules, improve efficacy or reduce side effects of the organism, its synthetic drugs have central nervous system stimulants fluticasone Seoul, substituted pyridines stomach cytoplasmic proton pump inhibitor Lansoprazole and Pariprazole, antiarrhythmic drugs flecainide with amines and analgesic drugs benzodiazepines and dysuria treatment KMD-3212 and so on.

Chemical properties

Boiling point is 73.6℃, melting point is-43.5℃, refractive index is 1.2940, density (25 ℃) is 1.383g/cm3, enthalpy of evaporation is 37.8kJ/mol.

Uses

(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl).
(2) It can be used for chemical reagents.
(3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates.
(4) It can be used as solvent, it is also used as medicine, pesticide intermediates.

Preparation method

Since 1933 Swarts used trifluoroacetic anhydride as raw material, catalytic reduction method was used to get trichloroethanol, we have developed a series of synthetic methods. According to the type, the reaction can be divided into three kinds: oxidation, reduction and hydrolysis. According to raw material, it can be divided trifluoroacetic acid method, trifluoroacetyl chloride method, trifluoroacetic anhydride method, trifluoroacetate law, trifluoroacetic acetaldehyde, polyvinylidene fluoride method, trifluoroethane (HFC-143a) method and trifluoro chloroethane (HCFC-133a) method.

Hazards & Safety Information

Category: Flammable liquid
Toxicity grading: highly toxic
Acute oral toxicity-rat LD50: 240 mg/kg; Oral-Mouse LD50: 366 mg/kg
Irritation data: Skin-Rabbit 0.75 mg/24 hours and severe; Eyes-rabbit 20 mg/24 hr mild
Flammability hazard characteristics: When meets fire, heat, oxidants, it is flammable; it can burn and generate toxic fluoride fumes.
Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants.
Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Chemical Properties

Colorless liquid

Uses

2,2,2-Trifluoroethanol (Trifluoroethyl alcohol, TFE) is used to study the conformational states of proteins and the folding refolding processes of proteins.

Uses

Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

Uses

In synthesis of medical anaesthetics, pharmaceuticals, and agrochemicals; in polymerizations. Protein denaturant; stabilizes peptide structures. Cleaning solvent; eluent in HPLC separations; working fluid in Rankine heat cycle systems. Environmentally friendly alternative to CFCs.

Definition

ChEBI: 2,2,2-trifluoroethanol is a fluoroalcohol. It is functionally related to an ethanol.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dry it with CaSO4 and a little NaHCO3 (to remove traces of acid) and distil it. Highly TOXIC vapour. [Beilstein 1 IV 1370.]

2,2,2-Trifluoroethanol Preparation Products And Raw materials

Raw materials

2,2,2-Trifluorodiazoethane Benzene, [(2,2,2-trifluoroethoxy)methyl]- 4-(prop-1-en-2-yl)phenyl acetate

Preparation Products

6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID 3,3,3-Trifluoropropionic acid 2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBOXYLIC ACID TRIFLUOROACETALDEHYDE HYDRATE TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE
Isoflurane 2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride 1,1,1,2-Tetrafluoroethane 2-CHLORO-1,1,1-TRIFLUOROETHANE pent-1-en-3-yne
1,3,2-Dioxaphospholane, 2-(2,2,2-trifluoroethoxy)-, 2-oxide 2-Hydroxy-1,3,2-dioxaphospholane 2-oxide 2,6-BIS(2,2,2-TRIFLUOROETHOXY)BENZONITRILE 2,2,2-TRIFLUOROETHYL CHLOROFORMATE 1,1,2,3,3,3-HEXAFLUOROPROPYL 2,2,2-TRIFLUOROETHYL ETHER
Potassium trifluoroacetate

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2,2,2-Trifluoroethanol Suppliers

Global( 514)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co,.LTD 		+8619930503252 daisy@crovellbio.com China 5964 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Beijing Sunsoly S&T Co.,Ltd 		+8613910445483 amanda@sunsoly.com China 283 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 925 58
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2141 58
Win-Win Chemical CO., Limited 		0086-577-64498589 sales@win-winchemical.com CHINA 998 58
Supplier Advantage
Hebei Guanlang Biotechnology Co,.LTD 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Beijing Sunsoly S&T Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Win-Win Chemical CO., Limited 		58

Related articles

View Lastest Price from 2,2,2-Trifluoroethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,2,2-Trifluoroethanol pictures 2023-08-31 2,2,2-Trifluoroethanol
75-89-8
 US $0.00 / kg 0.5kg 99% 100kg Beijing Sunsoly S&T Co.,Ltd
2,2,2-Trifluoroethanol pictures 2023-08-12 2,2,2-Trifluoroethanol
75-89-8
 US $20.00 / kg 1kg 99.99% 50000tons Henan Bao Enluo International TradeCo.，LTD
2,2,2-Trifluoroethanol pictures 2023-07-27 2,2,2-Trifluoroethanol
75-89-8
 US $1.50 / g 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd

2,2,2-Trifluoroethanol Spectrum

2,2,2-Trifluoroethanol(75-89-8)MS2,2,2-Trifluoroethanol(75-89-8)1HNMR2,2,2-Trifluoroethanol(75-89-8)13CNMR2,2,2-Trifluoroethanol(75-89-8)IR12,2,2-Trifluoroethanol(75-89-8)Raman

75-89-8(2,2,2-Trifluoroethanol)Related Search:

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Trifluoro Ethanol(L) 2,2,2-Trifluoroethanol,Trifluoroethyl alcohol 2,2,2-Trifluoroethanol, reagent grade 2,2,2-Trifluoroethan-1-ol 99% 2-Hydroxy-1,1,1-trifluoroethane, (Trifluoromethyl)methanol 2,2,2-TRIFLUOROETHANOL-D3, HIGH ENRICHMENT 1,2,2-trifluoroethan-1-ol 2,2,2-Trifluoroethanol (TFE) ,2,2-Trifluoroethyl alcohol 2(3H)-Benzofuranone, 5-hydroxy- 5-Hydroxy-3H-1-benzofuran-2-one b,b,b-Trifluoroethyl alcohol 2,2,2-TRIFLUOROETHANOL, 99.8%, EXTRA PURE 2,2,2-Trifluoroethanol, extra pure 2,2,2-Trifluoroethanol, extra pure, 99.8% 100ML 2,2,2-Trifluoroethanol, extra pure, 99.8% 25ML 2,2,2-Trifluoroethanol, extra pure, 99.8% 500ML 2,2,2-Trifluroroethanol 2,2,2-Trifluoroethanol (TFEA) Three fluorine ethanol 2,2,2-Trifluor Transcription factor for IgH enhancer 2,2,2-Trifluoroethanol ReagentPlus(R), >=99% 1,1H-perfluoroethanol 2,2,2-Thifluoroethanol 2,2,2-trifluoro-ethano TRIFLUOROETHYL ALCOHOL VITAS-BB TBB000650 BETA,BETA,BETA-TRIFLUOROETHANOL BETA,BETA,BETA-TRIFLUOROETHYL ALCOHOL 2,2,2-Trifluoroethanol,99% 2,2,2-trifluoroethanol, nmr grade PERFLUORO-1,1-DIHYDROETHANOL 2,2,2-trifluoroethylalcohol beta,beta,beta-trifluoroethanol2,2,2-trifluoroethylalcohol,tfe Ethanol,2,2,2-trifluoro- Fluorinol 85 Trifluoroethylalchohol trifluroroethylalchohol TFE/TFEA 2，2，2-Trifiuoroethyl alcohol 2,2,2-TRIFLUOROETHANOL 1H,1H-TRIFLUOROETHANOL Trifluoroethanol1 Trifluoroethanol2 2,2,2-Tridluoroethanol 2,2,2,-Trifluoroehtanol 2,2,2-TRIFLUOROETHANOL, CALIB. STANDARD FOR NMR-SPECTROSCOPY 2,2,2-TRIFLUOROETHANOL, 99.5+%, NMR GRAD E 2,2,2-TRIFLUOROETHANOL, REAGENTPLUS, >=99% 2 2 2-TRIFLUOROETHANOL 99.5+% & 2,2,2-Trifluoroethanol, extra pure, 99.8% 2,2,2-TRIFLUOROETHANOL: 99.95%, NMR GRADE 2,2,2-TRIFLUOROETHANOL, NMR GRADE: 99.5% 2,2,2-TRIFLUOROETHANOL, 99%2,2,2-TRIFLUOROETHANOL, 99%2,2,2-TRIFLUOROETHANOL, 99% 2,2,2-Trifluoroethanol (TFEA), NMR grade 2,2,2-TrifL uoroethanoL