Carmofur
- CAS No.
- 61422-45-5
- Chemical Name:
- Carmofur
- Synonyms
- hcfu;HCFUTM;Mifurol;CARMOFUR;Carmofur >Carmofur Carmofur;Carmofur, ≥ 98.0%;Carmofur USP/EP/BP;5-FLUORO-1-HEXYLCARBAMOYLURACIL;1-hexylcarbamoyl-5-fluorouracil
- CBNumber:
- CB5748051
- Molecular Formula:
- C11H16FN3O3
- Molecular Weight:
- 257.26
- MDL Number:
- MFCD00866284
- MOL File:
- 61422-45-5.mol
- MSDS File:
- SDS
| Melting point | 110-111 |
|---|---|
| Density | 1.2287 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 6.94±0.10(Predicted) |
| color | white to off-white |
| Merck | 14,1844 |
| CAS DataBase Reference | 61422-45-5(CAS DataBase Reference) |
| FDA UNII | HA82M3RAB2 |
| ATC code | L01BC04 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H361 | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 60-61-25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UV7714000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Carmofur price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1494 | Carmofur ≥98% (HPLC), powder | 61422-45-5 | 10mg | $95.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | C1494 | Carmofur ≥98% (HPLC), powder | 61422-45-5 | 50mg | $388 | 2024-03-01 | Buy |
| TCI Chemical | C2663 | Carmofur >98.0%(HPLC)(T) | 61422-45-5 | 5g | $621 | 2024-03-01 | Buy |
| Cayman Chemical | 14243 | Carmofur ≥98% | 61422-45-5 | 1g | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 14243 | Carmofur ≥98% | 61422-45-5 | 5g | $274 | 2024-03-01 | Buy |
Carmofur Chemical Properties,Uses,Production
Description
Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil . It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide , C16 ceramide , and C14 ceramide in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
Originator
Mifurol,Mitsui,Japan,1981
Uses
antineoplastic
Uses
Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .
Definition
ChEBI: Carmofur is an organohalogen compound and a member of pyrimidines.
Manufacturing Process
13.0 g (0.10 mol) of 5-fluorouracil was suspended in 60 ml of dimethyl
acetamide, then 14.0 g (0.11 mol) of n-hexyl isocyanate was added thereto at
room temperature and stirred at 50°C for 8 hours. After the reaction mixture
was concentrated under reduced pressure, the residue was poured into 400 ml
of water and resultant precipitate was filtered off. The precipitate was washed
and dried and 19.3 g (75.0% yield) of 5-fluoro-1-(n-hexylcarbamoyl)uracil
was obtained.
The product was recrystallized from ether and there were obtained white
crystals melting at 283°C (decomposition).
Therapeutic Function
Antineoplastic
Biochem/physiol Actions
Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.
Carmofur Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
View Lastest Price from Carmofur manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Carmofur
61422-45-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Carmofur
61422-45-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | Carmofur USP/EP/BP
61422-45-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Carmofur
61422-45-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Carmofur
61422-45-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Carmofur USP/EP/BP
61422-45-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited