N-Ethylmaleimide
- CAS No.
- 128-53-0
- Chemical Name:
- N-Ethylmaleimide
- Synonyms
- NEM;1-ETHYL-1H-PYRROLE-2,5-DIONE;N-Ethylmaleinimide;1H-Pyrrole-2,5-dione, 1-ethyl-;NEMI;NSC 7638;N-Ethylm;usafb-121;USAF B-121;ethvlmaleimide
- CBNumber:
- CB5748314
- Molecular Formula:
- C6H7NO2
- Molecular Weight:
- 125.13
- MDL Number:
- MFCD00005509
- MOL File:
- 128-53-0.mol
| Melting point | 43-46 °C(lit.) |
|---|---|
| Boiling point | 210 °C(lit.) |
| Density | 1.2500 (rough estimate) |
| refractive index | 1.4430 (estimate) |
| Flash point | 73 °C |
| storage temp. | 2-8°C |
| solubility | methanol: 1 M at 20 °C, clear, colorless |
| form | Crystalline Powder |
| pka | -2.18±0.20(Predicted) |
| color | White to off-white |
| Water Solubility | 1 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| Merck | 14,3822 |
| BRN | 112448 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate. |
| InChIKey | HDFGOPSGAURCEO-UHFFFAOYSA-N |
| CAS DataBase Reference | 128-53-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | O3C74ACM9V |
| NIST Chemistry Reference | 1H-pyrrole-2,5-dione, 1-ethyl-(128-53-0) |
| EPA Substance Registry System | N-Ethylmaleimide (128-53-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H311-H314-H317 | |||||||||
| Precautionary statements | P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 21-28-34-43-20/21 | |||||||||
| Safety Statements | 26-28-36/37/39-45-28A | |||||||||
| RIDADR | UN 2928 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UX9625000 | |||||||||
| F | 19 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29251900 | |||||||||
| NFPA 704 |
|
N-Ethylmaleimide price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 04260 | N-Ethylmaleimide purum p.a., ≥99.0% (HPLC) | 128-53-0 | 5G-F | $90.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04260 | N-Ethylmaleimide purum p.a., ≥99.0% (HPLC) | 128-53-0 | 25G-F | $286 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04259 | N-Ethylmaleimide BioUltra, ≥99.0% (HPLC) | 128-53-0 | 5g | $170 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04259 | N-Ethylmaleimide BioUltra, ≥99.0% (HPLC) | 128-53-0 | 25g | $661 | 2024-03-01 | Buy |
| Sigma-Aldrich | 04260 | N-Ethylmaleimide purum p.a., ≥99.0% (HPLC) | 128-53-0 | 5G | $86.7 | 2023-01-07 | Buy |
N-Ethylmaleimide Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
In cancer research (possible antimitotic activity.)
Uses
Reagent for the covalent modification of cysteine residues in proteins. NEM gives a clear solution in ethanol at 50 mg/ml. NEM dissolves in water (>50 mg in 4 ml); however, aqueous solutions are unstable. The rate of hydrolysis is pseudo-first order and significantly dependent on pH.
Uses
N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg2+ dependent internucleosomal DNA fragmentation.
Definition
ChEBI: N-ethylmaleimide is a member of the class of maleimides that is the N-ethyl derivative of maleimide. It has a role as an EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor, an EC 2.7.1.1 (hexokinase) inhibitor, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor and an anticoronaviral agent. It is functionally related to a maleimide.
Hazard
Lachrymator when liquid, a strong irritant.
Biochem/physiol Actions
Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
Safety Profile
Poison by intraperitoneal route. Human mutation data reported. Vapors are hlghly irritating. When heated to decomposition it emits toxic fumes of NOx.
N-Ethylmaleimide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from N-Ethylmaleimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-08-26 | N-Ethylmaleimide
128-53-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-20 | N-Ethylmaleimide
128-53-0
|
US $0.00-0.00 / KG | 5mg | 99% HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-07-13 | N-Ethylmaleimide
128-53-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- N-Ethylmaleimide
128-53-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- N-Ethylmaleimide
128-53-0
- US $0.00-0.00 / KG
- 99% HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- N-Ethylmaleimide
128-53-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd