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ChemicalBook >> CAS DataBase List >>3,4-DIHYDROQUINOLIN-2(1H)-ONE

3,4-DIHYDROQUINOLIN-2(1H)-ONE

3,4-DIHYDROQUINOLIN-2(1H)-ONE Structure
3,4-DIHYDROQUINOLIN-2(1H)-ONE structure
CAS No.
553-03-7
Chemical Name:
3,4-DIHYDROQUINOLIN-2(1H)-ONE
Synonyms
3,4-DIHYDRO-1H-QUINOLIN-2-ONE;HYDROCARBOSTYRIL;3,4-DIHYDRO-2(1H)-QUINOLINONE;inone;DIHYDROCARBOSTYRIL;dihydro-α-quinolone;3,4-Dihydrocarbostyril;3,4-Dihydro-2-quinolone;3,4-Dihydro-2(1H)-quinoL;3,4-Dihydro-2-quinolinone
CBNumber:
CB5772351
Molecular Formula:
C9H9NO
Molecular Weight:
147.17
MDL Number:
MFCD00016722
MOL File:
553-03-7.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:02
Request For Quotation

3,4-DIHYDROQUINOLIN-2(1H)-ONE Properties

Melting point 165-167 °C (lit.)
Boiling point 267.28°C (rough estimate)
Density 1.1135 (rough estimate)
refractive index 1.5200 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form Crystalline Powder
pka 14.76±0.20(Predicted)
color Off-white
Water Solubility Slightly soluble in water.
Sensitive Light Sensitive
Merck 13,4800
CAS DataBase Reference 553-03-7(CAS DataBase Reference)
FDA UNII 2CKG6TX32F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS06
Signal word  Warning
Hazard statements  H301-H302-H315-H317-H319-H335
Precautionary statements  P280a-P301+P310a-P405-P501a-P261-P280-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-43
Safety Statements  26-36/37
RIDADR  2811
WGK Germany  2
Hazard Note  Irritant
HazardClass  6.1(b)
PackingGroup  III
HS Code  29337900
NFPA 704
0
2 0

3,4-DIHYDROQUINOLIN-2(1H)-ONE price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 415936 3,4-Dihydro-2(1H)-quinolinone 98% 553-03-7 10g $171 2023-06-20 Buy
Sigma-Aldrich 415936 3,4-Dihydro-2(1H)-quinolinone 98% 553-03-7 1g $39.4 2023-01-07 Buy
Alfa Aesar H36638 3,4-Dihydro-2-(1H)-quinolinone, 98% 553-03-7 1g $42.65 2024-03-01 Buy
Alfa Aesar H36638 3,4-Dihydro-2-(1H)-quinolinone, 98% 553-03-7 5g $128.65 2024-03-01 Buy
Alfa Aesar H36638 3,4-Dihydro-2-(1H)-quinolinone 98% 553-03-7 25g $440 2021-12-16 Buy
Product number Packaging Price Buy
415936 10g $171 Buy
415936 1g $39.4 Buy
H36638 1g $42.65 Buy
H36638 5g $128.65 Buy
H36638 25g $440 Buy

3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline powder

Uses

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Uses

3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Definition

ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D

General Description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

3,4-DIHYDROQUINOLIN-2(1H)-ONE synthesis

83-33-0
553-03-7
Synthesis of 3,4-DIHYDROQUINOLIN-2(1H)-ONE from 1-Indanone

3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

N-BOC-3,4-Dihydro-2(1H)-quinolinone 3-CHLORO-N-PHENYLPROPANAMIDE 1-Indanone

Preparation Products

Cilostazol VESNARINONE 2-dioxaborolan-2-yl)quinolin-2(1H)-one 6,8-DINITRO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE 6,8-Dichloro-3,4-dihydro-1H-quinolin-2-one
6,8-Dibromo-3,4-dihydroquinolin-2(1H)-one

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3,4-DIHYDROQUINOLIN-2(1H)-ONE Suppliers

Global( 182)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81148696 +8615536356810 1047@dideu.com China 3408 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
Hebei Zhanyao Biotechnology Co. Ltd 		15369953316 +8615369953316 admin@zhanyaobio.com China 2136 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hebei Zhanyao Biotechnology Co. Ltd 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,2,3,4-Tetrahydroquinolin-2-one pictures 2022-03-04 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 US $1.10 / g 1g 99.00% 100 Tons Dideu Industries Group Limited
1,2,3,4-Tetrahydroquinolin-2-one pictures 2021-10-15 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 US $10.00 / KG 1KG 99% 20 tons Hebei Zhanyao Biotechnology Co. Ltd
1,2,3,4-Tetrahydroquinolin-2-one pictures 2020-04-29 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

3,4-DIHYDROQUINOLIN-2(1H)-ONE Spectrum

3,4-DIHYDROQUINOLIN-2(1H)-ONE(553-03-7)IR

553-03-7(3,4-DIHYDROQUINOLIN-2(1H)-ONE)Related Search:

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DIHYDROCARBOSTYRIL 3,4-DIHYDRO-2(H)-QUINOLINE 3,4-DIHYDRO-2(1H)-QUINOLONE 1,2,3,4-Tetrahydroquinolin-2-one 2-OXO-1,2,3,4-TETRAHYDROQUINOLINE 2-OXO-1,3,4-TRIHYDROQUINOLINE dihydro-α-quinolone o-aminohydrocinnamic acid lactam 3,4-Dihydrocarbostyril 3,4-DIHYDRO-1H-QUINOLIN-2-ONE, 99+% 2-Oxo-1,2,3,4-tetrahydroquinoline, 3,4-Dihydrocarbostyril 3,4-Dihydroquinolin-2(1H)-one 97% 4-Dihydro-2(1H)-quinolinone 3,4-Dihydro-2-quinolone 1,2,3,4-Tetrahydro-2(1H)-quinolinone 1,2,3,4-Tetrahydro-2-oxoquinoline 3,4-Dihydro-2-quinolinone 1,2,3,4-Tetrahydroquinoline-2-one 3,4-Dihydro-2(1H)-quinolinone,98% 3,4-Dihydro-2(1H)-quinolinoneHydrocarbostyril 2(1H)-Quinolinone, 3,4-dihydro- 3,4-Dihydro-2(1H)-quinolinone, 97+% 3,4-Dihydro-2(1H)-quinolinone 98% 3,4-Dihydro-2(1H)-quinoL inone 1,2,3,4-Tetrahydroquinolin-2-one ISO 9001：2015 REACH 4-Tetrahydroquinolin-2-one HYDROCARBOSTYRIL 3,4-DIHYDRO-2(1H)-QUINOLINONE 3,4-DIHYDRO-1H-QUINOLIN-2-ONE 3,4-DIHYDROQUINOLIN-2(1H)-ONE 553-03-7 C6H4CH2CH2CONH Building Blocks Quinolines Heterocyclic Building Blocks Quinolines, Isoquinolines & Quinoxalines Heterocycles pharmacetical API intermediates