CALCINEURIN

CAS No.
90371-51-0
Chemical Name:
CALCINEURIN
Synonyms
CAN;PP2B;PPASE-2B;CALCINEURIN;CALCINEURIN/PP2B;CALCINEURIN, HUMAN;PROTEIN PHOSPHATASE 2B;Calcineurin bovine brain;MODULATOR BINDING PROTEIN;CALMODULIN BINDING PROTEIN
CBNumber:
CB5781726
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00130697
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

CALCINEURIN Properties

storage temp. −20°C
solubility H2O: soluble
form lyophilized powder

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

CALCINEURIN price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1907 Calcineurin from bovine brain lyophilizedpowder,≥2,500?units/mgprotein 90371-51-0 100units $740 2024-03-01 Buy
Usbiological 151626 Calcineurin 90371-51-0 200ul $436 2021-12-16 Buy
Usbiological 405761 Calcineurin 90371-51-0 1Kit $479 2021-12-16 Buy
Product number Packaging Price Buy
C1907 100units $740 Buy
151626 200ul $436 Buy
405761 1Kit $479 Buy

CALCINEURIN Chemical Properties,Uses,Production

Uses

Calcineurin from bovine brain has been used:

  • as a positive control in western blot analysis of oocytes and cumulus cells proteome
  • as a positive control in calmodulin (CaM)-agarose binding assay
  • to test its phosphatase activity in the presence of okadaic acid

General Description

Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.

Biochem/physiol Actions

Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.

CALCINEURIN Preparation Products And Raw materials

Raw materials

Preparation Products

CALCINEURIN Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
CALCINEURIN FROM BOVINE BRAIN, >10 U/MG calcium/calmodulin-activated protein phosphatase MODULATOR BINDING PROTEIN PP2B PPASE-2B PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI PROTEIN PHOSPHATASE 2B CAN CALMODULIN BINDING PROTEIN CALCINEURIN CALCINEURIN, HUMAN CALCINEURIN/PP2B Calcineurin bovine brain 90371-51-0