4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- CAS No.
- 86030-08-2
- Chemical Name:
- 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- Synonyms
- BTB-1;NSC156750;BTB 1; BTB1;LABOTEST-BB LT01147747;BTB 1 - NSC 156750 | NSC 658180;4-CHLORO-2-NITRODIPHENYL SULFONE;4-Chloro-2-nitrodiphenyl sulphone;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-chloro-2-nitro-1-(phenylsulphonyl)benzene
- CBNumber:
- CB5783210
- Molecular Formula:
- C12H8ClNO4S
- Molecular Weight:
- 297.71
- MDL Number:
- MFCD00052250
- MOL File:
- 86030-08-2.mol
| Melting point | 115 °C |
|---|---|
| Boiling point | 471.2±35.0 °C(Predicted) |
| Density | 1.476±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (30 mg/ml) |
| form | solid |
| color | White to off-white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2930909899 | |||||||||
| NFPA 704 |
|
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27219 | BTB-1 | 86030-08-2 | 500mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 27219 | BTB-1 | 86030-08-2 | 1g | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 27219 | BTB-1 | 86030-08-2 | 250mg | $40 | 2024-03-01 | Buy |
| Tocris | 5399 | BTB1 ≥99%(HPLC) | 86030-08-2 | 10 | $82 | 2021-12-16 | Buy |
| Tocris | 5399 | BTB1 ≥99%(HPLC) | 86030-08-2 | 50 | $345 | 2021-12-16 | Buy |
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties,Uses,Production
Description
BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5
Uses
BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.
storage
Store at +4°C
References
Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072 Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554 Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539 Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41 Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 18019252918 | sale@amkchem.com | China | 15415 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |
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