3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- structure

CAS No.: 2204442-75-9

Chemical Name:: 3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

Synonyms: (R)-4-Flourophenyl Aprepitant;5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-

CBNumber:: CB58140415

Molecular Formula:: C29H25F7N4O3

Molecular Weight:: 610.52

MDL Number:

MOL File:: 2204442-75-9.mol

Request For Quotation

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Properties

Density	1.44±0.1 g/cm3(Predicted)
pka	8.04±0.20(Predicted)

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Chemical Properties,Uses,Production

Uses

(R)-4-Flourophenyl Aprepitant is an impurity of Aprepitant (170729-80-3 #CAS), which is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemStrong Scientific Co.,Ltd	0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Guangzhou Juntang Technology Co., Ltd	020-36607679 13502246435	sales@dmstandards.com	China	10951	58
Scinova Biotech(Guangzhou) Co., Ltd.	13268215580	scinova_sales@163.com	China	7026	58
HUBEI MICRO PHARMACEUTICAL	18627055345	info@micropharm.cn	China	2758	58

Supplier	Advantage
ChemStrong Scientific Co.,Ltd	56
Guangzhou Juntang Technology Co., Ltd	58
Scinova Biotech(Guangzhou) Co., Ltd.	58
HUBEI MICRO PHARMACEUTICAL	58

3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4'-fluoro[1,1'-biphenyl]-4-yl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- 5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4'-fluoro-[1,1'-biphenyl]-4-yl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (R)-4-Flourophenyl Aprepitant 2204442-75-9