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Heterocyclic compound Benzol Refining Products Maximal allowed amount and maximal allowed residue Chemical Properties Uses Production methods
Chemical Name:
HLP;cp34;CP33;CP 34;CYP3A;NF-25;CP3A4;THIOLE;CYP3A3;Thiofen
Molecular Formula:
Formula Weight:
MOL File:

Thiophene Properties

Melting point:
-38 °C
Boiling point:
84 °C(lit.)
1.051 g/mL at 25 °C(lit.)
vapor density 
2.9 (vs air)
vapor pressure 
40 mm Hg ( 12.5 °C)
refractive index 
n20/D 1.529(lit.)
Flash point:
-9 °C
storage temp. 
Flammables area
explosive limit
Water Solubility 
Stable. Highly flammable. Incompatible with strong oxidizing agents, nitrates.
CAS DataBase Reference
110-02-1(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn,Xi,T
Risk Statements  45-46-11-20/21/22-41-52/53-36-20/22-37/38-22-48/20/21/22
Safety Statements  53-26-39-45-61-36/37/39-16-36
RIDADR  UN 2414 3/PG 2
WGK Germany  3
RTECS  XM7350000
Hazard Note  Irritant/Highly Flammable
HazardClass  3
PackingGroup  II
HS Code  29349990
Hazardous Substances Data 110-02-1(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H402 Harmful to aquatic life Hazardous to the aquatic environment, acute hazard Category 3
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Thiophene price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 06914 Thiophene analytical standard 110-02-1 1ml-f $16.5 2018-11-13 Buy
Sigma-Aldrich 06914 Thiophene analytical standard 110-02-1 5ml-f $53 2018-11-13 Buy
TCI Chemical T0223 Thiophene >98.0%(GC) 110-02-1 25mL $14 2017-12-01 Buy
TCI Chemical T0223 Thiophene >98.0%(GC) 110-02-1 500mL $43 2017-12-01 Buy
Sigma-Aldrich T31801 Thiophene ≥99% 110-02-1 500g $48.3 2018-11-13 Buy

Thiophene Chemical Properties,Uses,Production

Heterocyclic compound

Thiophene is five-member heterocyclic compounds containing a sulfur atom and is presented at coal tar crude benzene at small amounts. It is a kind of colorless liquid having similar order as benzene aromatic with the boiling point being 84 °C. It is insoluble in water, and can be mixed with ethanol, ethyl ether, acetone, benzene, carbon tetrachloride, heptane, pyridine, and 1,4-dioxane. It is flammable, and has a high heat resistance without being decomposed when being heated to 850 °C. It is not polymerized under acidic conditions, nor does it be decomposed and be susceptible to oxidation. It also has moderate toxicity. The 5 atoms in thiophene ring belong to sp2 hybrid and located in the same plane. The occupied p-orbital of a pair of non-sharing electrons in the sulfur atom is parallel and overlapped with that of occupies the 4 carbon atoms which form 5 atoms/6 electrons closing conjugated system and thus having aromaticity. Thiophene is more prone to have electrophilic substitution reaction than benzene with electrophilic substitution mainly occurring in α-position (2-position or 5-position). An important derivative of thiophene is biotin which can have sulfonation reaction with concentrated sulfuric acid at room temperature with producing 2-thiophene acid which can be dissolved in sulfuric acid. Thereby, people often use this method to remove the thiophene in the crude benzene.
Thiophene can be used in the production of various kinds of dyes, perfumes, thermal shock resistant plastic, highly active solvent, stimulating hormone, insecticide, brightening agents, cosmetics and bio-activating substances and vitamins, anesthetics and antibiotics. It can also be used as the raw materials of preparing a broad spectrum anthelmintic pyrantel as well as antibacterial drugs cephalosporin I and II. Moreover, it can be used for further preparation of solvents such as sulfolane. Using chemical or electrochemical method can enable the synthesis of polythiophene, and having a conductivity of 2~10.6 × 103S/m after doping, and thus is a kind of conductive polymer materials of potential application.

Benzol Refining Products

Although thiophene is able to be chemically synthesized, the cost is too high. Thiophene is presented inside both shale oil and coal tar. The waste acid of crude benzol fraction resulted from the coal tar washed by concentrated sulfuric acid can be used as raw materials. It first undergoes hydrolysis in 110~150 °C, and then separated and purified to obtain thiophene. Thiophene is mainly presented in light benzene purified from the pre-rectification of crude benzene. When the light benzene was refined by adding hydrogen, thiophene is destroyed. When using light benzene acid for refining it, most of thiophene is polymerized with unsaturated compounds into tar-like substance with only a small amount of thiophene taking reaction with sulfuric acid for generating thiophene sulfonic acid which is easily extracted, thus greatly reducing the yield of thiophene.
When using light benzene acid for refining, thiophene is reacted together with sulfuric acid to generate thiophene-sulfonic acid which is dissolved in wasting sulfuric acid, clarify the sulfuric acid, remove the tarry substance, followed by hydrolysis distillation. The distilled condensed stuff was cooled and separated to obtain the thiophene-containing and benzenoid hydrocarbons-containing distilled crude oil. The crude distilled oil was neutralized by adding alkaline to be neutral or slightly basic with a distillation column (with theoretical plate number of 30 to 40) for distillation to obtain thiophene product (with thiophene content higher than 90%). During the rectification process, separate out the middle distilled fraction and reflux it back into the crude oil distillate. After distilling all the amount of thiophene, people can also distill out product of inter-xylene product (with content being higher than 95%) from the waste residue.
For this method of extraction of thiophene from waste sulfuric acid, thiophene extraction efficiency from crude benzene is low and demanding using hydrolysis distillation equipment with corrosion resistant materials. In order to increase the extraction efficiency of thiophene, many countries are studying new ways of thiophene extraction method from crude benzene, from which the relative successful method is extraction & rectification extraction method for thiophene (ER method). The approach is adding a suitable extraction agent to thiophene containing benzene in order to increase the relative volatility between benzene and thiophene in order to separate out the thiophene from rectification. In many kinds of extracting agents, α-pyrrolidone and N-methylpyrrolidone (NMP) have a strong dissolving ability to although this extraction agent is only with moderate selectivity. However, it has good chemical property and thermal stability, and is easy for recycling. The price is relatively cheap. All the above points make it be an appropriate extraction agent.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Maximal allowed amount and maximal allowed residue

Maximal allowed amount and maximal allowed residue

Chemical Properties

It is colorless, transparent liquid with an aromatic odor similar to benzene. It is soluble in alcohol, ether and other organic solvents but insoluble in water.


1. It is used not only for the synthesis of cephalosporin drugs, but also for the production of dyes, synthetic resins, solvents, etc.
2. It is used for making drugs and plasticizers; thiophene is an important organic chemical raw material which has broad range of applications. It is mainly used for dyes, medicines and resins. It can be used for synthesis of new broad-spectrum cephalosporin antibiotic, and is an important pharmaceutical and chemical additive. It can also be applied for the manufacture of color films and trick photography and synthesizing a complicated reagent used for the extraction and separation of uranium and other metals.
3. It is used as the raw material and a plasticizer of medicine, dyes, and plastics.
4. It is mainly used as the intermediates of pharmaceutical industry used for preparing thiophene acetic pyridine, and pyrantel. It can also been used as a raw material for synthesizing resin and dye industry. It is also be used as an organic solvent. As a chemical reagent, it is used as a standard reagent for chromatography analysis.
5. It is used as a solvent, standard reference agent for chromatography analysis, and also for organic synthesis.
6. Thiophene can be used for the manufacture of dyes, pharmaceuticals and resin; used for the synthesis of new broad-spectrum cephalosporin antibiotics; used for the manufacture of color films and trick photography; used for the synthesis of some complex reagent; it is an important intermediate in the synthesis of Bakelite and resins. Thiophene itself is a good dewaxing solvents and paint cleaners. The derivatives of thiophene have a variety of pharmacological activities. There are a variety of thiophene-azo dyes with excellent performance. The sulfonylurea derivatives of thiophene are new herbicides of ultra-efficient as well as low toxicity. Other derivatives can also be used as insecticides, fungicides, and animal and plant growth-promoting agent. In addition, some derivatives of thiophene are also the component of organic semiconductors. In short, thiophene and its derivatives have a very important position in the pharmaceutical industry, dye industry, pesticide industry, resin industry, and chemical industry.

Production methods

Thiophene is presented in the shale oil and coal tar. First use the waste acid of crude benzene washing as the raw material for hydrolysis at 110-150 °C. The gas coming from hydrolysis is put into the overhead condenser through hydrolysis distillation column. The condensed product has content of 15%-25% thiophene, 50%-60% xylene, and also benzene, toluene, methyl thiophene and some unknown substances. Per ton of waste acid can be extracted out for about 10 kg distillation product. After dehydration with solid sodium hydroxide and further refined purification by distillation, you can get thiophene product of 90%-95%. Chemical synthesis of thiophene can use butane and sulfur as raw materials; butane first undergoes dehydrogenation and then form a ring with sulfur to form thiophene. Laboratory prepare thiophene through the reaction between 1,4-dicarbonyl compound and phosphorus trisulfide.

Chemical Properties

colourless to pale yellow liquid


Thiophene is used as a building block of various organic molecules and pharmaceuticals providing functional properties.


ChEBI: A monocyclic heteroarene that is furan in which the oxygen atom is replaced by a sulfur.


Solvent similar to benzene, but suitable for lower and higher temps; manufacture of resins from thiophene-phenol mixtures and formaldehyde; manufacture of dyes and pharmaceuticals.

General Description

A colorless liquid with an unpleasant odor. Insoluble in water and slightly denser than water. Flash point 30°F. Vapors heavier than air. Irritates the skin, eyes, and mucous membranes. Used to make pharmaceuticals and dyes.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Thiophene reacts violently with strong oxidizing agents and concentrated nitric acid causing fire and explosion hazards [Handling Chemicals Safely 1980. p. 899]. A mixture of Thiophene and N-nitrosoacetanilide exploded at 0°C [Ber., 1887, 30, 367].


Flammable, dangerous fire risk.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Purification Methods

The simplest purification procedure is to dry thiophen with solid KOH, or reflux it with sodium, and fractionally distil it through a glass-helices-packed column. More extensive treatments include an initial wash with aqueous HCl, then water, drying with CaSO4 or KOH, and passage through columns of activated silica gel or alumina. Fawcett and Rasmussen [J Am Chem Soc 67 1705 1945] washed thiophene successively with 7M HCl, 4M NaOH, and distilled water, dried with CaCl2 and fractionally distilled it. *Benzene was removed by fractional crystallisation by partial freezing, and the thiophene was degassed and sealed in Pyrex flasks. [Also a method is described for recovering the thiophene from the *benzene-enriched portion.] [Beilstein 17 H 29, 17 I 17, 17 II 35, 17 III/IV 234, 17/1 V 297.]

Thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

Thiophene Suppliers

Global( 255)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22119 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 894 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1465 55
career henan chemical co
+86-371-86658258 CHINA 10011 58
13867897135 CHINA 931 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40399 62

View Lastest Price from Thiophene manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-16 Thiophene
US $11.00 / KG 1KG 99% 1000KG

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