ChemicalBook >> CAS DataBase List >>Diethanolamine


Chemical Name:
DEA;Aliphatic amine;Diolamine;Diethanolamin;dela;Iminodiethanol;2,2'-Azanediyldiethanol;2-(2-hydroxyethylamino)ethanol;2,2-IMINODIETHANOL;2,2'-DIHYDROXYDIETHYLAMINE
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2023-09-07 18:57:57

Diethanolamine Properties

Melting point 28 °C (lit.)
Boiling point 217 °C/150 mmHg (lit.)
Density 1.097 g/mL at 25 °C (lit.)
vapor density 3.6 (vs air)
vapor pressure <0.98 atm ( 100 °C)
refractive index n20/D 1.477(lit.)
Flash point 280 °F
storage temp. 2-8°C
solubility H2O: 1 M at 20 °C, clear, colorless
form Viscous Liquid or Low Melting Solid
color APHA: ≤15
Specific Gravity 1.09
PH 11.0-12.0 (25℃, 1M in H2O)
pka 8.88(at 25℃)
Odor Mild ammoniacal; faint, fishy; characteristic.
explosive limit 2.1-10.6%(V)
Water Solubility MISCIBLE
Sensitive Hygroscopic
λmax λ: 260 nm Amax: 0.04
λ: 280 nm Amax: 0.02
Merck 14,3107
BRN 605315
Exposure limits TLV-TWA 3 ppm (~13 mg/m3) (ACGIH).
Stability Stable. Incompatible with carbon dioxide, strong acids, strong oxidizing agents. Deliquescent.
LogP -2.46 at 25℃
Indirect Additives used in Food Contact Substances DIETHANOLAMINE
FDA 21 CFR 175.105; 176.170; 176.180; 177.2800
CAS DataBase Reference 111-42-2(CAS DataBase Reference)
EWG's Food Scores 7-10
Proposition 65 List Diethanolamine
NIST Chemistry Reference Diethanolamine(111-42-2)
IARC 2B (Vol. 77, 101) 2013
EPA Substance Registry System Diethanolamine (111-42-2)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H302-H315-H318-H361fd-H373
Precautionary statements  P202-P280-P301+P312-P302+P352-P305+P351+P338-P308+P313
Hazard Codes  Xn
Risk Statements  22-38-41-48/22
Safety Statements  26-36/37/39-46
RIDADR  3267
WGK Germany  1
RTECS  KL2975000
Autoignition Temperature 689 °F
PackingGroup  II
HS Code  29221200
Toxicity LD50 orally in rats: 12.76 g/kg (Smyth)
NFPA 704
3 0

Diethanolamine price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.03116 Diethanolamine for synthesis 111-42-2 1L $81.8 2023-06-20 Buy
Sigma-Aldrich 8.03116 Diethanolamine for synthesis 111-42-2 5L $204 2023-06-20 Buy
Sigma-Aldrich 8.03116 Diethanolamine for synthesis 111-42-2 22kg $369 2023-06-20 Buy
Sigma-Aldrich 8.03116 Diethanolamine for synthesis 111-42-2 50L $659 2023-06-20 Buy
Sigma-Aldrich 31589 Diethanolamine BioUltra, ≥99.5% (GC) 111-42-2 100G $76.3 2023-06-20 Buy
Product number Packaging Price Buy
8.03116 1L $81.8 Buy
8.03116 5L $204 Buy
8.03116 22kg $369 Buy
8.03116 50L $659 Buy
31589 100G $76.3 Buy

Diethanolamine Chemical Properties,Uses,Production


Diethanolamine is an organic base which has been used as an emulsifying and dispersing agent.It can also be used as a basic buffer, with optimal pH about pH 9, if titrated with HCl or other acid. Other uses include: to "scrub" gases, as a chemical intermediate, as humectant or softening agent.

Chemical Properties

The USP32–NF27 describes diethanolamine as a mixture of ethanolamines consisting largely of diethanolamine. At about room temperature it is a white, deliquescent solid. Above room temperature diethanolamine is a clear, viscous liquid with a mildly ammoniacal odor.
Diethanolamine is used as surface-active agent in metal-cutting fluids and oils, as a corrosion inhibitor, as a dispersant in agricultural chemical formulations, and as an intermediate in the production of other compounds such as fatty acid condensates of diethanolamine which are extensively used in soaps and cosmetics as emulsifiers, thickeners, wetting agents and detergents (Beyer et al., 1983). In the cosmetic formulations, the concentration of diethanolamine may range from 1 to 25% (National Toxicology Program, 1999a).


Diethanolamine is used in the production ofsurface-active agents and lubricants for thetextile industry; as an intermediate for rubberchemicals; as an emulsifier; as a humectantand softening agent; as a detergent in paints,shampoos, and other cleaners; and as anintermediate in resins and plasticizers.


Diethanolamine similar to triethanolamine (T775580) is used as a surfactant. It also has the potential to be a corrosion inhibitor by means of chemisorption.


To scrub gases as indicated under ethanolamine. Diethanolamine can be used with cracking gases and coal or oil gases which contain carbonyl sulfide that would react with monoethanolamine. As rubber chemicals intermediate. In the manufacture of surface active agents used in textile specialties, herbicides, petroleum demulsifiers. As emulsifier and dispersing agent in various agricultural chemicals, cosmetics, and pharmaceuticals. In the production of lubricants for the textile industry. As humectant and softening agent. In organic syntheses.


ChEBI: A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.


Diethanolamine is prepared commercially by the ammonolysis of ethylene oxide. The reaction yields a mixture of monoethanolamine, diethanolamine, and triethanolamine which is separated to obtain the pure products.

Production Methods

Diethanolamine is produced with monoethanolamine and triethanolamine by ammonolysis of ethylene oxide; diethanolamine is then separated by distillation (Mullins 1978). In 1984, 166.2 million pounds of diethanolamine were produced in the United States (USTIC 1985).

General Description

Oily colorless liquid or solid white crystals. Slight rotten fish or ammonia odor. Denser than water.

Air & Water Reactions

Water soluble.

Reactivity Profile

2,2'-Iminodiethanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 2,2'-Iminodiethanol is hygroscopic. 2,2'-Iminodiethanol may be sensitive to exposure to air and light. 2,2'-Iminodiethanol can react with oxidizing materials, acids, CO2, copper alloys, aluminum, zinc, galvanized iron and copper.

Health Hazard

The irritant action of diethanolamine on theeyes can be severe. Direct contact of thepure liquid can impair vision. Irritation onthe skin may be mild to moderate. Theacute oral toxicity of this compound waslow in test animals. The toxic symptomsinclude somnolence, excitement, and musclecontraction.
LD50 value, oral (mice): 3300 mg/kg
The vapor pressure of diethanolamine isnegligibly low (<0.01 torr at 20°C (68°F)).At ordinary temperature, this compoundshould not cause any inhalation hazard. Themists, fumes, or vapors at high temperatures,however, can produce eye, skin, and respiratory tract irritation.
In contrast to monoethanolamine, dieth anolamine administered to mice at 1125 mg/kg/day caused no change in maternal mortality, litter size, or percentage survival of thepups (Environmental Health Research andTesting 1987).

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors are generated when heated.

Flammability and Explosibility

Non flammable

Chemical Reactivity

Reactivity with Water : No reaction; Reactivity with Common Materials: No reaction; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Pharmaceutical Applications

Diethanolamine is primarily used in pharmaceutical formulations as a buffering agent, such as in the preparation of emulsions with fatty acids. In cosmetics and pharmaceuticals it is used as a pH adjuster and dispersant.
Diethanolamine has also been used to form the soluble salts of active compounds, such as iodinated organic acids that are used as contrast media. As a stabilizing agent, diethanolamine prevents the discoloration of aqueous formulations containing hexamethylenetetramine-1,3-dichloropropene salts.
Diethanolamine is also used in cosmetics.

Industrial uses

Diethanolamine undergoes reactions characteristic of secondary amines and of alcohols. Two industrially important reactions of the ethanolamines involve reaction with carbon dioxide or hydrogen sulfide to yield water soluble salts, and reaction with long chain fatty acids to form neutral ethanolamine soaps (Mullins 1978). Substituted ethanolamine compounds, such as soaps, are used extensively as emulsifiers, thickeners, wetting agents, and detergents in cosmetic formulations (including skin cleaners, creams, and lotions) (Beyer et al 1983).
Diethanolamine is used as a dispersing agent in various agricultural chemicals, as an absorbent for acidic gases (hydrogen sulfide and carbon dioxide), as a humectant, as an intermediate in the synthesis of morpholine, as a surface-active agent in cutting fluids, as a corrosion inhibitor, as a component in textile specialty agents, and as a secondary vulcanization accelerator in the rubber industry. Diethanolamine is also used in cleaners and pharmaceutical ointments, in polyurethane formulations, in herbicides, and in a variety of organic syntheses (Beyer et al 1983; Mullins 1978; Windholz 1983). Diethanolamine is permitted in articles intended for use in the production, processing, or packaging of food (CFR 1981), and is permitted as a secondary direct food additive from use in delinting cottonseed in the production of cottonseed oil or meal cake (Fed. Reg. 1982). Because of the wide industrial and consumer uses, large amounts of this chemical are discharged into water and sewage in an unaltered form (Yordy and Alexander 1981).

Contact allergens

Diethanolamine is contained in many products, as a metalworking fuid. Traces may exist in other etha- nolamine-containing fuids.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. Mildly toxic by skin contact. A severe eye and mild skin irritant. Experimental reproductive effects. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, water, Co2, dry chemical. When heated to decomposition it emits toxic fumes such as NOx. See also AMINES.


Diethanolamine is used in topical and parenteral pharmaceutical formulations, with up to 1.5% w/v being used in intravenous infusions. Experimental studies in dogs have shown that intravenous administration of larger doses of diethanolamine results in sedation, coma, and death.
Animal toxicity studies suggest that diethanolamine is less toxic than monoethanolamine, although in rats the oral acute and subacute toxicity is greater. Diethanolamine is said to be heptacarcinogenic in mice and has also been reported to induce hepatic choline deficiency in mice.
Diethanolamine is an irritant to the skin, eyes, and mucous membranes when used undiluted or in high concentration. However, in rabbits, aqueous solutions containing 10% w/v diethanolamine produce minor irritation. The lethal human oral dose of diethanolamine is estimated to be 5–15g/kg body-weight.
The US Cosmetic Ingredient Review Expert Panel evaluated diethanolamine and concluded that it is safe for use in cosmetic formulations designed for discontinuous, brief use followed by thorough rinsing from the surface of the skin. In products intended for prolonged contact with the skin, the concentration of ethanolamines should not exceed 5%. Diethanolamine should not be used in products containing N-nitrosating agents.
LD50 (guinea pig, oral): 2.0g/kg
LD50 (mouse, IP): 2.3g/kg
LD50 (mouse, oral): 3.3g/kg
LD50 (rabbit, skin): 12.2g/kg
LD50 (rat, IM): 1.5g/kg
LD50 (rat, IP): 0.12g/kg
LD50 (rat, IV): 0.78g/kg
LD50 (rat, oral): 0.71g/kg
LD50 (rat, SC): 2.2g/kg

Potential Exposure

Diethanolamine is present in machining and grinding fluids and has been detected in workplace air in the metal manufacturing industry. It was present in bulk cutting fluids at levels ranging from 4 to 5% (Kenyon et al., 1993). Diethanolamine has also been reported to be present in wetting fluids used in road paving. A level of 0.05 mg/m3 was detected in a stationary sample at a slurry machine discharging a bitumen emulsion containing 0.2% of the amine. All personal exposures were below the detection limit (0.02 mg/m3) (Levin et al., 1994). In a German study (1992–94), diethanolamine was measured in samples of metalworking fluids in a range of 0–44% (n = 69). The number of samples with diethanolamine present steadily declined from 90% to 60% over the study period (Pfeiffer et al., 1996).


When DEA was administered cutaneously to pregnant rats and rabbits during organogenesis, developmental toxicity (skeletal variations) was observed only in the rat and only at doses causing significant maternal toxicity.
The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) is 3ppm (13mg/m3).


Treatment of Wistar or Sherman rats with diethanolamine caused increases in the formation of hepatic phospholipids (Artom et al 1949). In addition, dietary administration led to incorporation of ethanolamine into hepatic phospholipids (Artom et al 1949), and repeated oral administration of diethanolamine in drinking water (one to three wk) at a dose of 320 mg/kg/d was found to reduce the level of incorporation of ethanolamine and choline into hepatic and renal phospholipids in Sprague-Dawley rats (Barbee and H?rtung 1979b).
Dermal absorption of diethanolamine is suggested to occur in rats since Nnitrosodiethanolamine was excreted in the urine of male Sprague-Dawley rats which had been administered diethanolamine by dermal application and given nitrite in their drinking water (Preussman et al 1981).


Diethanolamine is hygroscopic and light- and oxygen-sensitive; it should be stored in an airtight container, protected from light, in a cool, dry place.


UN2491 Ethanol amine or Ethanolamine solutions, Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Fractionally distil the amine twice, then fractionally crystallise it from its melt. Its solubility in H2O is 10% at 20o. [Perrin & Dempsey Buffers for pH and Metal Ion Control Chapman & Hall, London 1974, Beilstein 4 H 283, 4 II 729, 4 III 689, 4 IV 1514.]


Diethanolamine is a secondary amine that contains two hydroxy groups. It is capable of undergoing reactions typical of secondary amines and alcohols. The amine group usually exhibits the greater activity whenever it is possible for a reaction to take place at either the amine or a hydroxy group.
Diethanolamine will react with acids, acid anhydrides, acid chlorides, and esters to form amide derivatives, and with propylene carbonate or other cyclic carbonates to give the corresponding carbonates. As a secondary amine, diethanolamine reacts with aldehydes and ketones to yield aldimines and ketimines. Diethanolamine also reacts with copper to form complex salts. Discoloration and precipitation will take place in the presence of salts of heavy metals.

Waste Disposal

Controlled incineration; incinerator equipped with a scrubber or thermal unit to reduce nitrogen oxides emissions

Regulatory Status

Included in the FDA Inactive Ingredients Database (IV infusions, ophthalmic solutions, and topical preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Diethanolamine Preparation Products And Raw materials

Raw materials

Preparation Products


Global( 845)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
15028179902 +8615028179902 China 11007 58
Hebei Fengqiang Trading Co., LTD
+86-13373049370 +86-13373049370 China 1000 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21975 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 China 2990 55
Tianjin Zhongxin Chemtech Co., Ltd.
+86-022-66880623 +8618622897568 China 554 58
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967 China 1011 58
career henan chemical co
+86-0371-86658258 China 29922 58
+86 18953170293 CHINA 2933 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 CHINA 28184 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 China 6387 58

Related articles

  • Health Hazard of Diethanolamine
  • Diethanolamine contains a secondary amine and two alcohol groups. It is a viscous liquid with a freezing point of 28 oC. It is....
  • Jan 7,2022

View Lastest Price from Diethanolamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diethanolamine pictures 2023-09-27 Diethanolamine
US $5.00 / kg 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd
Diethanolamine pictures 2023-09-07 Diethanolamine
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
DEA Diethanolamine pictures 2023-09-06 DEA Diethanolamine
US $1.80 / Kg/Drum 17.63KG 99.5% 1000tons/month Hebei Dongdu Import and Export Co. LTD
  • Diethanolamine pictures
  • Diethanolamine
  • US $5.00 / kg
  • ≥98%
  • Jinan Finer Chemical Co., Ltd
  • Diethanolamine pictures
  • Diethanolamine
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
2,2'-IMINODIETHANOL 2,2'-IMINODIETHANOL,BIS(BETA-HYDROXYETHYL)AMINE Bis(beta-hydroxyethyl)amine DETHANOLOMINE Diethanlamine (DEA) DIETHANOLAMINE, ACS DIETHANOLAMINE 98.5% A.C.S. REAGENT DIETHANOLAMINE PURE DIETHANOLAMINE SIGMAULTRA DIETHANOLAMINE, STANDARD FOR GC DIETHANOLAMINE GC STANDARD Diethanolamine85C4H11NO2 Diethanolamine99 β,β'-dihydroxydiethyl-amine DIETHANOLAMINE REAGENT (ACS) Diethanolamine-etheylene-D8 bis(á-hydroxyethyl)amine DIETHANOLAMINE,NF 2,2'-di(hydroxyethyl)-amine DIETHANOLAMINE FOR ANALYSIS EMSURE DEA)DiethanolaM Diethanolamine ACS reagent, >=98.5% Diethanolamine puriss. p.a., ACS reagent, >=99.0% (GC) Diethanolamine reagent grade, >=98.0% L-ASCORBIC ACID FREE ACID ACS GRADE 2-((2-hydroxyethyl)amino)ethanol 2-(2-hydroxy-ethylamino)-ethanol Diethanolamine BioUltra, >=99.5% (GC) Ethanol, 2,2'-iminobis- Ethanol, 2,2'-iminodi- Ethanol,2,2’-iminobis- N,N-Bis(2-hydroxyethyl)amine N,N-Diethanolamine NCI-C55174 DIETHYLOLAMINE DIETHANOLAMINE SUBSTRATE BUFFER DIETHANOLAMINE DI-BETA-HYDROXYETHYLAMINE DI(2-HYDROXYETHYL)AMINE BIS(2-HYDROXYETHYL)AMINE BIS(2-HYDROXYETHYL)AMINE IMINODIETHANOL LABOTEST-BB LTBB000446 2,2'-iminodiethanol diethanolamine 2,2μ-Iminodiethanol, Bis(2-hydroxyethyl)amine 2,2′-iminodiehanol,diethanolamine 11456
Amine diethanol Diethanolamine [Matrix for FABMS and liquid SIMS] Iminodiethyl alcohol 2,2'-Iminodiethanol, Diethanolamine, 2,2'-Dihydroxydiethylamine Diethanolamine 80% Aqueous Diethanolamine 85% Aqueous Diethanolamine 88% Aqueous Diethanolamine (3 mL) DiethanolaMine, 99% 1KG 2,2'-Dihydroxydiethylamine 2,2'-Iminodiethanol DIETHANOLAMINE FOR SYNTHESIS 2-(2-hydroxyethylamino)-ethanol