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o-Toluic acid

CAS No.
118-90-1
Chemical Name:
o-Toluic acid
Synonyms
2-METHYLBENZOIC ACID;o-toluic;o-Totuic acid;ORTHO-TOLUIC ACID;uic acid;2-TOLUIC ACID;O-TOLUIC ACID;O-TOLUYLIC ACID;o-ToluicAcid>o-Methylbenzoate
CBNumber:
CB5852905
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MDL Number:
MFCD00002477
MOL File:
118-90-1.mol
MSDS File:
SDS
Last updated:2023-04-27 16:27:43

o-Toluic acid Properties

Melting point 102-104 °C (lit.)
Boiling point 258-259 °C (lit.)
Density 1.062 g/mL at 25 °C (lit.)
refractive index 1.512
Flash point 148 °C
storage temp. Sealed in dry,Room Temperature
solubility 1.2g/l
form Needle-Like Crystalline Solid
pka 3.91(at 25℃)
color White to slightly yellow
Specific Gravity 1.062
PH 3.1 (H2O, 20℃)(saturated aqueous solution)
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 14,9535
BRN 1072103
Stability Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey ZWLPBLYKEWSWPD-UHFFFAOYSA-N
CAS DataBase Reference 118-90-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9NR3033Y0U
NIST Chemistry Reference Benzoic acid, 2-methyl-(118-90-1)
EPA Substance Registry System o-Toluic acid (118-90-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36-22
WGK Germany  3
RTECS  XU1400000
TSCA  Yes
HS Code  29163900
NFPA 704
0
2 0

o-Toluic acid price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T36404 o-Toluic acid 99% 118-90-1 100g $63.1 2024-03-01 Buy
Sigma-Aldrich T36404 o-Toluic acid 99% 118-90-1 500g $121 2024-03-01 Buy
TCI Chemical T0292 o-Toluic Acid >98.0%(T) 118-90-1 25g $43 2024-03-01 Buy
TCI Chemical T0292 o-Toluic Acid >98.0%(T) 118-90-1 100g $77 2024-03-01 Buy
Alfa Aesar A13856 o-Toluic acid, 98+% 118-90-1 250g $29.65 2024-03-01 Buy
Product number Packaging Price Buy
T36404 100g $63.1 Buy
T36404 500g $121 Buy
T0292 25g $43 Buy
T0292 100g $77 Buy
A13856 250g $29.65 Buy

o-Toluic acid Chemical Properties,Uses,Production

Chemical Properties

White crystals. Slightly soluble in water; soluble in alcohol and chloroform. Combustible.

Uses

Bacteriostat.

Uses

o-Toluic acid is part of a group of Benzoic acid (B203900) derivatives that possess inhibitory activity against mushroom tyrosinases. o-Toluic acid is also used as a reagent to synthesize halogen-substituted benzoic acids (such as 2,4-Dichlorobenzoic acid [D431955]), which have potential muscle stimulating effects.

Definition

ChEBI: A methylbenzoic acid that is benzoic acid substituted by a methyl group at position 2.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 588, 1943
The Journal of Organic Chemistry, 25, p. 616, 1960 DOI: 10.1021/jo01074a035
Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7

Air & Water Reactions

Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.

Reactivity Profile

o-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in o-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. o-Toluic acid is incompatible with strong oxidizers.

Fire Hazard

Flash point data for o-Toluic acid are not available. o-Toluic acid is probably combustible. Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.

Purification Methods

Crystallise the acid from *benzene (2.5mL/g) and dry in air. The S-benzylisothiuronium salt has m 146o (from aqueous EtOH). [Beilstein 9 IV 1697.]

89-95-2
118-90-1
Synthesis of o-Toluic acid from 2-Methylbenzyl alcohol
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View Lastest Price from o-Toluic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
o-Toluic acid pictures 2023-04-22 o-Toluic acid
118-90-1
US $30.00-10.00 / kg 10kg 99% 100000kg Hebei Guanlang Biotechnology Co,.LTD
o-Toluic acid pictures 2023-04-12 o-Toluic acid
118-90-1
US $1.00 / Kg/Bag 1Kg/Bag 99.56% HPLC 5000tons/year Wuhan Dujiang Industrial Co., Ltd.
o-Toluic acid pictures 2023-01-31 o-Toluic acid
118-90-1
US $0.00 / Kg/Drum 1KG 99% 1000tons Hebei Mojin Biotechnology Co., Ltd
  • o-Toluic acid pictures
  • o-Toluic acid
    118-90-1
  • US $30.00-10.00 / kg
  • 99%
  • Hebei Guanlang Biotechnology Co,.LTD
  • o-Toluic acid pictures
  • o-Toluic acid
    118-90-1
  • US $1.00 / Kg/Bag
  • 99.56% HPLC
  • Wuhan Dujiang Industrial Co., Ltd.
  • o-Toluic acid pictures
  • o-Toluic acid
    118-90-1
  • US $0.00 / Kg/Drum
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
2-methyl-benzoicaci Benzoicacid,2-methyl- o-TOLUIC ACID pure o-methyl benzoic acid,o-toluic acid ORTHO TOLUIC ACID ( OTA ) O-Toluic acid ,99% o-Toluic acid, 98+% 100GR o-Toluic acid, 98+% 5GR o-Toluic acid,2-Methylbenzoic acid o-Toluic acid 99% 2-Methylbenzoic acid for synthesis 2-TOLUIC ACID AKOS BBS-00003722 METHYLBENZOIC(O-) ACID o-Methylbenzoate O-METHYLBENZOIC ACID O-TOLUYLIC ACID O-TOLUIC ACID RARECHEM AL BO 0033 2-Methylbenzoic Acid/o-Toluic acid O-ToluicAcidForSynthesis 2-ToluicAcid98+% o-Toluic acid, 98+% ORTHO-TOLUIC ACID FOR SYNTHESIS o-Toluic acid118-90-1 Alogliptin Related Compound 46 2-methylbenzoate uic acid [Carbonyl-14C1]-toluic acid [Phenyl-U-14C6]-toluic acid o-ToluicAcid> Tolvaptan Impurity 52 OTA,o-Toluic acid o-Toluic acid ISO 9001:2015 REACH High Pharmaceutical O-Toluic Acid 2-Methylbenzoic Acid CAS?118-90-1 o-Toluic Acid pure, 99.5% 2-METHYLBENZOIC ACID ORTHO-TOLUIC ACID o-toluic o-Totuic acid Ortho Toluic Acid (2-Methyl Benzoic Acid) 118-90-1 110-90-1 CH3C6H4COOH 118901 Organic Building Blocks ARYL ACID Carbonyl Compounds Carboxylic Acids C8 Building Blocks Pyrazines ,Pyrans intermediates Organic acids