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4'-Methylacetophenone

4'-Methylacetophenone Structure
4'-Methylacetophenone structure
CAS No.
122-00-9
Chemical Name:
4'-Methylacetophenone
Synonyms
4-METHYLACETOPHENONE;P-METHYLACETOPHENONE;FEMA 2677;P-ACETYLTOLUENE;4-ACETYLTOLUENE;1-p-tolyl-ethanone;4’-methyl-acetophenon;4-METHYLPHENACYL BROMIDE;1-(4-Methylphenyl)ethanone;Ethanone,1-(4-methylphenyl)-
CBNumber:
CB5852945
Molecular Formula:
C9H10O
Molecular Weight:
134.18
MDL Number:
MFCD00008751
MOL File:
122-00-9.mol
MSDS File:
SDS
Last updated:2024-03-26 14:13:49
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4'-Methylacetophenone Properties

Melting point 22-24 °C (lit.)
Boiling point 226 °C (lit.)
Density 1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)
vapor pressure 0.52 hPa (25 °C)
FEMA 2677 | 4'-METHYLACETOPHENONE
refractive index n20/D 1.533(lit.)
Flash point 198 °F
storage temp. Store below +30°C.
solubility 2.07g/l
form Liquid
color Clear colorless to pale yellow
Odor at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone
Odor Type floral
explosive limit 1.00%(V)
Water Solubility 0.37 g/L (15 ºC)
JECFA Number 807
BRN 606053
InChIKey GNKZMNRKLCTJAY-UHFFFAOYSA-N
LogP 2.1 at 25℃
Substances Added to Food (formerly EAFUS) 4'-METHYLACETOPHENONE
CAS DataBase Reference 122-00-9(CAS DataBase Reference)
FDA UNII AX66V0KX3Y
NIST Chemistry Reference Ethanone, 1-(4-methylphenyl)-(122-00-9)
EPA Substance Registry System Ethanone, 1-(4-methylphenyl)- (122-00-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P332+P313
Hazard Codes  Xn
Risk Statements  36/37/38-22-20/21/22
Safety Statements  26-27-37/39-24/25-23-36
RIDADR  UN 1325 4.1/PG 2
WGK Germany  3
RTECS  AM9463000
TSCA  Yes
HS Code  29143900
Toxicity LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
NFPA 704
1
0 0

4'-Methylacetophenone price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 1kg $95.1 2024-03-01 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 5kg $503 2024-03-01 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 10Kg $601 2024-03-01 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 25kg $1390 2024-03-01 Buy
Sigma-Aldrich M26615 4′-Methylacetophenone 95% 122-00-9 100g $48.9 2024-03-01 Buy
Product number Packaging Price Buy
W267708 1kg $95.1 Buy
W267708 5kg $503 Buy
W267708 10Kg $601 Buy
W267708 25kg $1390 Buy
M26615 100g $48.9 Buy

4'-Methylacetophenone Chemical Properties,Uses,Production

Description

4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared by slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Chemical Properties

4'-Methylacetophenone has been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone. 4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand hawthorn-type perfumes, especially soap perfumes.

Occurrence

Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry, celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry, mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked cabbage, mandarin juice.

Uses

4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics.

Uses

4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.

Definition

ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.

Preparation

By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Taste threshold values

Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like.

Synthesis Reference(s)

Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032
Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2

General Description

4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.

Safety Profile

Moderately toxic by ingestion. A human skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]

4'-Methylacetophenone synthesis

766-97-2
122-00-9
Synthesis of 4'-Methylacetophenone from 4-Ethynyltoluene

4'-Methylacetophenone Preparation Products And Raw materials

Raw materials

Benzyl chloride Acetyl chloride Aluminum chloride Semicarbazide

Preparation Products

4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE 4-Acetylbenzoic acid 5-P-TOLYL-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE
4-(1,2,3-THIADIAZOL-4-YL)BENZOYL CHLORIDE CYAZOFAMID 4-Ethynyltoluene ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE
Naphthalene, 1,2,3,4-tetrahydro-1,6-dimethyl-4-(1-methylethyl)-, (1R,4R)-rel- ar-turmerone 2-Bromo-4'-methylacetophenone Methyl 4-methylbenzoate 3,5-DIBROMO-4-METHYLBENZOIC ACID
2-AMINO-4-(P-TOLYL)THIAZOLE 1-(4-(Bromomethyl)phenyl)ethanone

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4'-Methylacetophenone Suppliers

Global( 778)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5993 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9427 58
Shandong Zhishang New Material Co., Ltd.
+8617653113209 sales002@sdzschem.com China 3050 58
Dorne Chemical Technology co. LTD 		+86-13583358881 +86-18560316533 Ethan@dornechem.com China 293 58
Firsky International Trade (Wuhan) Co., Ltd 		+8615387054039 admin@firsky-cn.com China 436 58
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 305 58
Wuhan Quanjinci New Material Co.,Ltd. 		+8615271838296 kyra@quanjinci.com China 1532 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Shandong Hanjiang Chemical Co., Ltd 		+86-0533-2066820 +8618369939125 hanson@sdhanjiang.com China 1527 58
Wuhan Xinhao Biotechnology Co., Ltd 		+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd.
58
Baoji Guokang Healthchem co.,ltd
58
Shandong Zhishang New Material Co., Ltd.
58
Dorne Chemical Technology co. LTD 		58
Firsky International Trade (Wuhan) Co., Ltd 		58
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Wuhan Quanjinci New Material Co.,Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Shandong Hanjiang Chemical Co., Ltd 		58
Wuhan Xinhao Biotechnology Co., Ltd 		58

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View Lastest Price from 4'-Methylacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Methylacetophenone pictures 2024-04-18 4'-Methylacetophenone
122-00-9
 US $20.00 / KG 1KG 99% 300 Tons/ year Speranza Chemical Co., Ltd.
4'-Methylacetophenone pictures 2024-04-18 4'-Methylacetophenone
122-00-9
 US $10.00 / ASSAYS 1ASSAYS 99% 10 ton Dorne Chemical Technology co. LTD
4'-Methylacetophenone pictures 2024-04-18 4'-Methylacetophenone
122-00-9
 US $40.00-11.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD

4'-Methylacetophenone Spectrum

4'-Methylacetophenone(122-00-9)MS4'-Methylacetophenone(122-00-9)1HNMR4'-Methylacetophenone(122-00-9)13CNMR4'-Methylacetophenone(122-00-9)IR14'-Methylacetophenone(122-00-9)IR24'-Methylacetophenone(122-00-9)Raman

122-00-9(4'-Methylacetophenone)Related Search:

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Chalcone Kresoxim-methyl 4-Methylphenylacetic acid 4'-Chloroacetophenone Tribenuron methyl
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Acetophenone, 4'-methyl- Esberiven Melilot Melilotal p-Acetotoluene Sweet clover Yellow melilot Yellow sweet clover 4-METHYLACETOPHENONE 97+% 4-Methyacetophenone p-METHYLACETOPHENONE technical 4-Met-17Iyl acetopllenone p-Tolyl methyl ketone Methyl 4-methylphenyl ketone METHYLACETOPHENONE, 4-(SG) 4′-Methylacetophenone ,98% 4′-Methylacetophenone,Methyl p-tolyl ketone 4-Methylacetophenone, synthesis grade 1-(4-Methylphenyl)-1-ethanone 1-(4-Tolyl)ethanone 4-Methyl-1-acetylbenzene 4'-Methylacetophen 4-Methylhypnone The Methyl acetophenone 4'-Methylacetophenone Vetec(TM) reagent grade, 94% 4'-Methylacetophenone,95% (4-Methylphenyl) methyl ketone 1-(4-methylphenyl)-ethanon 1-(4-methyl-phenyl)-ethanone 1-(4-methylphenyl)-Ethanone 1-(4-Methylpheyl)ethanone BUTTPARK 41\03-57 METHYL P-TOLYL KETONE 1-(4-METHYLPHENYL)ETHAN-1-ONE 1-acetyl-4-methyl benzene 1-METHYL-4-ACETYLBENZENE 2-BROMO-1-(4-METHYLPHENYL)-1-ETHANONE AKOS BBS-00003271 AKOS BBS-00000936 4-(BROMOACETYL)TOLUENE 4'-METHYLACETOPHENONE (4-METHYLPHENYL)ETHANONE METHYLACETOPHENONE-4 METHYL 4-TOLYL KETONE 1-Methyl-4-acetylbenzen 4-Methylacetophenone (p-) p-methylphenyl methyl ketone 4'-Methylacetophenone 4-Acetyltoluene 4-Methylacetophenone 4'-METHYLACETOPHENONE 95+% FCC Ethanone, 1-(4-methylphenyl)- (9CI) 4-acetyltoluene,p-methylacetophenone,(p-methylphenyl)-methylketone P-Methyl 4'-(SG) METHYLPARA-TOLYLKETONE METHYLACETOPHENON Tolperisone Impurity G 1-(4-Methylpheyl)e Tolperisone Impurity 7