Chinese Japanese Germany Korea


Aminophenol p-Aminophenol Preparation Toxicity and protection Chemical Properties Uses Category Toxicity grading Acute toxicity Skin irritation data Flammable and hazardous characteristics Storage characteristics Extinguishing agents Professional standard
4-Aminophenol structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

4-Aminophenol Properties

Melting point:
188 °C
Boiling point:
284 °C
vapor pressure 
0.4 hPa (110 °C)
refractive index 
1.5444 (estimate)
Flash point:
189 °C
storage temp. 
water: slightly soluble
Crystalline Powder
5.48, 10.30(at 25℃)
White to cream
Water Solubility 
1.5 g/100 mL (20 ºC)
Air & Light Sensitive
284 °C
Stable, though may discolour in air. Incompatible with acids, chloroformates, strong oxidizing agents.
CAS DataBase Reference
123-30-8(CAS DataBase Reference)
EWG's Food Scores
NIST Chemistry Reference
Phenol, 4-amino-(123-30-8)
EPA Substance Registry System
p-Aminophenol (123-30-8)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302+H332-H341-H410-H317-H320-H334-H361-H370-H372-H302-H332-H400
Precautionary statements  P201-P202-P260-P264-P270-P271-P272-P284-P302+P352+P333+P313+P363-P304+P340+P312-P305+P351+P338+P337+P313-P307+P311-P391-P405-P280h-P302+P352-P501a-P273-P281-P501-P261-P280-P301+P312+P330
Hazard Codes  Xn,N
Risk Statements  20/22-50/53-68-40-R68-R50/53-R20/22
Safety Statements  28-36/37-60-61-28A-S61-S60-S36/37-S28A
RIDADR  UN 2512 6.1/PG 3
WGK Germany  3
RTECS  SJ5075000
Autoignition Temperature >250 °C
HazardClass  6.1
PackingGroup  III
HS Code  28402090
HS Code  29222900
Toxicity LD50 orally in Rabbit: 375 mg/kg LD50 dermal Rabbit > 10000 mg/kg
NFPA 704
4 0

4-Aminophenol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 35837 4-Aminophenol PESTANAL , analytical standard 123-30-8 1g $18.1 2021-03-22 Buy
Sigma-Aldrich 8.00421 4-Aminophenol for synthesis 123-30-8 5 g $28.21 2021-03-22 Buy
Sigma-Aldrich 8.00421 4-Aminophenol for synthesis 123-30-8 250 g $33.58 2021-03-22 Buy
Sigma-Aldrich 8.00421 4-Aminophenol for synthesis 123-30-8 1 kg $72.43 2021-03-22 Buy
Sigma-Aldrich Y0001955 Paracetamol impurity K European Pharmacopoeia (EP) Reference Standard 123-30-8 $128 2021-03-22 Buy

4-Aminophenol Chemical Properties,Uses,Production


Aminophenol, also known hydroxy-aniline, amino hydroxy benzene, have three kind of isomers, namely o-aminophenol, m-aminophenol, and p-aminophenol (4-amino-phenol). In1874, Baeyer et al had first successfully obtained aminophenol. Owing to the difference of the relative positions of hydroxy group and amino group, the three kinds of isomers also have different physical chemical properties. This product exhibits weak alkalinity and weak acidicity and a strong reduction capability. Owing to the simultaneous existence of both amino group and phenol group, it has the property of both of them. It is very unstable upon air and sunlight, and is especially sensitive to oxygen to oxygen in the humid air, and can have its color further deepened due to that the ortho-position and para-position are more susceptible to oxidation. It mainly generates amino phenoxazine derivatives after oxidation.
The main function of aminophenol is being used as a photographic developer and dye intermediates. It can be used for production of acid dyes, direct dyes, sulfur dyes, azo dyes, fur dyes and mordant dyes. The m-Aminophenol and para-aminophenol can be used as the raw materials of pharmaceutical purpose as the raw materials of herbicides, fungicides and insecticides and thermal dye material. O-aminophenol can also be used as the inhibitor of alkaline metal corrosion, dyes, the anti-aging agents of rubber anti-aging, antioxidants, stabilizers, oil additives, and catalyst of organic reaction, chemical reagents (m-aminophenol can be used as the analysis agent of gold and silver assay) as well as the organic synthesis intermediates.
The above information is edited by the Chemicalbook of Dai Xiongfeng.


p-Aminophenol is a kind of commonly used intermediate of refined chemical industrial product presented in China. In the dye industry, it is applied to the synthesis of weakly acidic yellow 6G, weak acid yellow 5G, vulcanization blue 3R, Sulphur Blue CV, vulcanization Brilliant Green GB, sulfur red brown B3R, C.I.Sulphur Black 6(53295) and so on. In the pharmaceutical industry, it is used for the synthesis of paracetamol, clofibrate and so on. It is also used in the preparation of the developer, antioxidants and oil additives and other products.
P-aminophenol, also known as 4-aminophenol, p-hydroxy aniline, 4-amino-1-hydroxybenzene, and 4-hydroxyaniline, have two patterns: α-type which is precipitated from water, ethanol and ethyl acetate and is white to pale yellow orthorhombic lamellae; double-cone type crystal which is precipitated from acetone. It has a strong reduction capability and is susceptible to air oxidation. It will exhibit gray brown color upon exposure to the light or air, especially in the wet air. It has a melting point of 189.6~190.2 ℃ and can subject to sublimation without decomposition at 110 ℃ (1.467 × 103Pa). It has a boiling point of being 284 (decomposition). It is slightly soluble in benzene, chloroform and petroleum ether, and can be dissolved in ethanol, ethyl ether and water. Its solubility in water: 1.1 upon 0.0 ℃, 3.01 upon 59.0 ℃, 6.44 upon 77.0 ℃, 10.09 upon 86.7 ℃, 19.53 upon 96.6 ℃, and 33.42 upon 102.0 ℃. It quickly becomes brown after being dissolved in alkaline solution. Upon reaction with inorganic acids, it can generate water-soluble salts. When coming across ferric chloride or sodium hypochlorite, its aqueous solution will exhibit purple color. The oxidation of this product in diethyl ether with silver oxide generates quinone imine while oxidation with lead dioxide or silver nitrate generates p-benzoquinone. Reaction of this product with excess amount of chlorine generates multi-chloranil. Sulfonated with fuming sulfuric acid can generate 4-amino-phenol-sulfonic acid. Under mild conditions, using acetic anhydride for acylation can produce N-acetyl phenol. The reaction with sodium nitrite can cause diazotization. Rat-oral-LD50:1270mg/kg.
Aminophenol is mainly used in the manufacture of antipyretic analgesic paracetamol as well as manufacturing of various kinds of dyes such as sulfur vulcanization Blue FBL, Sulphur Blue CV, vulcanization Brilliant Green GB, sulfur red brown B3R, black sulfide reduction CLG, vulcanization blue 3R, fur dye brown fur P and so on. It can also used for synthesis of the stabilizer of polymer materials such as 4-hydroxy-diphenylamine, N, N'-diphenyl-1, 4-phenylenediamine, and N-(4-hydroxyphenyl)-2-naphthylamine. Moreover, it can applied to the synthesis of photographic developer N-methyl-p-amino phenol.


There are various ways for production it including iron reduction, nitrification phenol method, and coupling reduction method. 1. Iron reduction; it can be produced by the reduction of the p-nitro phenol. Fixed material consumption: 1388 kg/t of dinitrophenol (industrial), 1778 kg/t of iron powder, as well as 200 kg/t of 30% hydrochloric acid. 2. Phenol nitrosation method; it can be produced by phenol which goes through nitrosation, reduction and acid precipitation. 3. The coupling reduction; it can be made using aniline which goes through diazotization, coupling, and reduction through iron powder. 4. The catalytic hydrogenation of nitrobenzene; it is generally using platinum, palladium, or both of them as the catalyst for the hydrogenation and reduction of nitrobenzene into phenylhydroxylamine in 10-20% sulfuric acid aqueous solution; then it is further converted to p-aminophenol with the yield being 70-80%. Supplement of surface active agent in the reaction system has certain effect on increasing the yield. 5. The electrolytic reduction of nitrobenzene; Mitsui Toatsu Fine Chemicals companies has applied electrolytic reduction of nitrobenzene in sulfuric acid solution; it further undergoes transposition via phenylhydroxylamine into p-amino phenol; In June 1977, the company built a plant with annual production of 1000 tons in Omuta.
p-nitro chlorobenzene can subject to hydrolysis in sodium hydroxide to sodium p-nitrophenol, which can be reduced by iron powder to become 4-amino-phenol reduction after acidification.
Prepare a sodium hydroxide solution of a concentration of 137 to 140 g/L in the kettle and then add it to the hydrolysis reactor; add into the molten nitro chlorobenzene and heat up to 152 ℃ with the pressure in the autoclave being 0.4~0.42MPa (gauge pressure); stop heating and the heat released from the hydrolysis reaction can increase the temperature and pressure temperature to 165 ℃, 0.6MPa (gauge pressure) respectively for reaction of 3 hours, take the sample for analysis. After the oil distillate content is lower than 0.5%, the hydrolysis reaction has reached to the end point. Cool to 120 ℃, add water and 98% concentrated sulfuric acid to the first crystallization vessel, and then pressed into the hydrolyzate and cool to 50~55 ℃; further add concentrated sulfuric acid to ensure the Congo red test paper exhibiting purple color and continue for cooling to 30 ℃; Perform centrifugal filtration for dehydration.
Add the last round of mother liquor which has been subject to p-amino-phenol purification and filtration into the reduction kettle, heat to 90 ℃ and add iron powder and 30% hydrochloric acid; Alternately add iron powder and p-nitro-phenol under boiling state with the feeding process depending on the reaction conditions for example upon overflow pan, we should fill the cold purified and filtrated mother liquor. Upon boiling and reduction to the end (add the droplet of the reaction liquid on the white filter paper should yield no color for the infiltration ring), supply a certain amount of heat refined mother liquor and add magnesium oxide until to the reaction mixture without iron ions. Stand static for 30 minutes; discharge the supernatant; the iron mud in the under layer was subject to crystallization under 98 ℃; Filter the mother liquor and perform pulping, filter again with the filtrate beaten into the second crystallizer.
In the second crystallizer, lower the temperature within 4 hours to 60~65 ℃ and transfer into the third crystallizer within 4 hours for further reducing the temperature to 25 ℃; Maintain for 30 minutes and perform centrifugation again.
Prepare a sodium bisulfite solution with the SO2 content being 4% to 5% in the refining kettle of 4% to 5%, add the crystallized and filtered cake and stir for 1.5 hours, centrifuge and filtrate with the filter cake being subject to vacuum air drying to generate the finished product of p-aminophenol. The refined mother liquor can be recycled to be used in the next round of reduction reaction.

Toxicity and protection

It is toxic. The p-amino phenol has double toxicity of both aniline and phenol. Absorption of it through the skin can cause dermatitis as well as cause methemoglobinemia and asthma. The contact of its hydrochloride with the skin can cause severe itching or eczema. Subcutaneous injection-cats-half lethal dose-LD50: 37mg/kg.

Chemical Properties

It is white or light yellow-brown crystals. It is slightly soluble in water and ethanol but insoluble in benzene and chloroform. It will quickly exhibit brown color after being dissolved in alkaline solution.


It can be used for the production of Sulphur Blue FBG and weak acid dyes such as yellow 5G. It can be used for the manufacturing of drugs such as paracetamol and clofibrate as well as being used as developer and antioxidants, etc.
It can be used as the reagents for the analysis.
The product is the intermediate of pharmaceutical intermediates, dyes and other fine chemicals. It can be used for the production of paracetamol, azo dyes, sulfur dyes, acid dyes, fur dye and developer, antioxidants as well as oil additive.
It is widely used in the synthesis of pharmaceuticals, dyes and other organic products and is mainly for the synthesis of paracetamol, clofibrate ketone, vitamin B1 and compound nicotinamide.
It can be used as the raw material of medicine and dyes, antioxidants and the developer.
It can be used for gold assay as well as determination of copper, iron, magnesium, vanadium, nitrite and cyanate, antioxidants.


toxic substances

Toxicity grading

highly toxic

Acute toxicity

oral-rat LD50: 375 mg/kg; intraperitoneal-mouse LDL0: 100 mg/kg.

Skin irritation data

Rabbit 12.5 mg/24 hours Mild; Eyes-rabbit mild 100 mg.

Flammable and hazardous characteristics

it is combustible upon fire and can be subject to thermal decomposition; burning of it release toxic fumes of nitrogen oxide.

Storage characteristics

Treasury: ventilation, low-temperature and drying; oxidants, store it separately from food additives.

Extinguishing agents

carbon dioxide, foam, powder, sand, water spray.

Professional standard

STEL 1 mg/m3


This hair dye is frequently implicated in contact dermatitis in hairdressers.

Chemical Properties

o-Aminophenol appears as colorless needles or as white crystalline substance turning tan to brown on exposure to air.

Chemical Properties

Off white granular powder


Nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580).


photographic developer; intermediate in the manufacture of sulfur and azo dyes; dyeing textiles, hair, fur and feathers; pharmaceuticals; antioxidants; oil additives


Oxidative dye; developing agent for photographic processes; precursor for pharmaceuticals; used in hair dyes


ChEBI: An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.

Synthesis Reference(s)

Synthesis, p. 285, 1971
Tetrahedron Letters, 34, p. 2441, 1993 DOI: 10.1016/S0040-4039(00)60436-7

General Description

White or reddish-yellow crystals or light brown powder. Turns violet when exposed to light.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Heat (decomposition forming HCN, nitrous vapors, CO); water (CO2); reacts violently with acids, bases, alcohols and amines causing fire and explosion hazards [Handling Chemicals Safely 1980 p. 647].

Health Hazard

p-Aminophenol is of moderately low toxicity but has caused dermal sensitization and kidney injury; the potential for producing methemoglobin is of relatively minor importance.
The oral LD50 in rats was 671 mg/kg.1 Effects included central nervous system depression. A solution of 2.5% applied to abraded skin of rabbits was a mild irritant.1 p- Aminophenol caused dermal sensitization in guinea pigs, and skin sensitization has been reported in humans.2,3 The dermal LD50 in rabbits was greater than 8 g/kg, which strongly suggests that absorption through the skin is minimal.4 Single nonlethal acute doses in rats produced proximal renal tubular necrosis of the pars recta.

Fire Hazard

Flash point data are not available for 4-Aminophenol. 4-Aminophenol is probably combustible.

Contact allergens

This hair dye is frequently implicated in contact dermatitis in hairdressers, customers, or people sensitized to para-phenylenediamine, by the way of “blackhenna” temporary tattoos.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. An allergen and skin and eye irritant. Mutation data reported. Can cause contact dermatitis, bronchial asthma, and methemoglobinemia with cyanosis. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Workers may be exposed to oAminophenol during its use as a chemical intermediate; in the manufacture of azo and sulfur dyes; and in the photographic industry. There is potential for consumer exposure to o-Aminophenol because of its use in dyeing hair, fur, and leather. The compound is a constituent of 75 registered cosmetic products suggesting the potential for widespread consumer exposure. p-Aminophenol is used mainly as a dye, dye intermediate and as a photographic developer; and in small quantities in analgesic drug preparation. Consumer exposure to p-aminophenol may occur from use as a hairdye or as a component in cosmetic preparations. mAminophenol is used mainly as a dye intermediate


UN2512 Aminophenols (o-; m-; p-), Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise it from EtOH, then water, excluding oxygen. It sublimes at 110o/0.3mm. It has been purified by chromatography on alumina with a 1:4 (v/v) mixture of absolute EtOH/*benzene as eluent. [Beilstein 13 IV 1014.]


These phenol/cresol materials can react with oxidizers; reaction may be violent. Incompatible with strong reducing substances such as alkali metals, hydrides, nitrides, and sulfides. Flammable gas (H2) may be generated, and the heat of the reaction may cause the gas to ignite and explode. Heat may be generated by the acidbase reaction with bases; such heating may initiate polymerization of the organic compound. Reacts with boranes, alkalies, aliphatic amines, amides, nitric acid, sulfuric acid. Phenols are sulfonated very readily (e.g., by concentrated sulfuric acid at room temperature). These reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid and can explode when heated. Many phenols form metal salts that may be detonated by mild shock.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.

4-Aminophenol Preparation Products And Raw materials

Raw materials

Preparation Products

4-Aminophenol Suppliers

Global( 505)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20010 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 26734 60
Anhui Royal Chemical Co., Ltd.
+86-025-86655873 CHINA 536 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 3001 55
career henan chemical co
+86-371-86658258 CHINA 29959 58
13867897135 CHINA 925 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 CHINA 1314 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5508 58

View Lastest Price from 4-Aminophenol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-27 4-Aminophenol
US $10.00 / KG/Tin 1KG 99% 10 Tons Hebei Senko Biotechnology Co., Ltd.
2021-10-15 4-aminophenol
US $0.00 / Kg/Bag 1Kg/Bag 99% 20ton Hebei Mojin Biotechnology Co., Ltd
2021-09-07 4-Aminophenol
US $50.00 / Kg/Bag 1Kg/Bag Above 99% 5000kg/month Hebei Zhanyao Biotechnology Co. Ltd

4-Aminophenol Spectrum

123-30-8(4-Aminophenol)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved