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Heptafluorobutyric acid

Heptafluorobutyric acid
Heptafluorobutyric acid structure
CAS No.
375-22-4
Chemical Name:
Heptafluorobutyric acid
Synonyms
HFBA;FC-23;H 0024;NSC 820;IPC-PFFA-4;Fluorad FC 23;uorobutyric acid;PERFLUOROBUTYRATE;EDMAN REAGENT NO 3;RARECHEM AL BO 0423
CBNumber:
CB5853573
Molecular Formula:
C4HF7O2
Formula Weight:
214.04
MOL File:
375-22-4.mol

Heptafluorobutyric acid Properties

Melting point:
-17.5 °C
Boiling point:
120 °C755 mm Hg(lit.)
Density 
1.645 g/mL at 25 °C(lit.)
vapor density 
7 (vs air)
vapor pressure 
~10 mm Hg ( 25 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
120-121°C
storage temp. 
Store below +30°C.
form 
Powder
pka
pK1:0.17 (25°C)
Specific Gravity
approximate 1.6
color 
Clear colorless to faint yellow
PH
1 (H2O, 20℃)
Water Solubility 
miscible
Sensitive 
Light Sensitive
BRN 
1426882
InChIKey
YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference
375-22-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
12VHZ8L29I
NIST Chemistry Reference
Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System
Heptafluorobutyric acid (375-22-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H318-H314
Precautionary statements  P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P305+P351+P338-P310
Hazard Codes  C
Risk Statements  34-35
Safety Statements  26-36/37/39-45
RIDADR  UN 3265 8/PG 2
WGK Germany  3
RTECS  ET4025000
3-8-10
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29159000

Heptafluorobutyric acid price More Price(40)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 164194 Heptafluorobutyric acid 98% 375-22-4 5g $18.6 2021-12-16 Buy
Sigma-Aldrich 52411 Heptafluorobutyric acid for ion chromatography, ≥99.5% (GC) 375-22-4 5 mL $35.2 2021-12-16 Buy
Sigma-Aldrich 164194 Heptafluorobutyric acid 98% 375-22-4 25g $45.8 2021-12-16 Buy
Sigma-Aldrich 52411 Heptafluorobutyric acid for ion chromatography, ≥99.5% (GC) 375-22-4 25 mL $120 2021-12-16 Buy
Sigma-Aldrich 49540 Heptafluorobutyric acid solution 0.5?M in H2O, LiChropur?, suitable for ion pair chromatography 375-22-4 100 mL $605 2021-12-16 Buy

Heptafluorobutyric acid Chemical Properties,Uses,Production

Chemical Properties

Clear colorless to faintly yellow liquid

Uses

Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

Uses

Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.

Definition

ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.

Hazard

Irritant to tissue.

Purification Methods

Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]

Heptafluorobutyric acid Preparation Products And Raw materials

Raw materials

Preparation Products


Heptafluorobutyric acid Suppliers

Global( 220)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15421 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Fluoropharm Co., Ltd.
+8613336034509
+86 0571-85586753 sales@fluoropharm.com China 982 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
BEYOND INDUSTRIES (CHINA) LIMITED
+8613917686115
+862162570268 sales@beyondindustriesgroup.com CHINA 704 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10008 58

View Lastest Price from Heptafluorobutyric acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-05 Heptafluorobutyric acid
375-22-4
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
2019-07-06 Heptafluorobutyric acid
375-22-4
US $1.00 / KG 1KG 99% 200KG Career Henan Chemical Co

Heptafluorobutyric acid Spectrum


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