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2,5-Dihydroxybenzoic acid

2,5-Dihydroxybenzoic acid
2,5-Dihydroxybenzoic acid structure
CAS No.
490-79-9
Chemical Name:
2,5-Dihydroxybenzoic acid
Synonyms
DHB;2,5-Dhba;Gentisic;Gensigen;Gensigon;Gentisate;GENTISIC ACID;2,5-Dihydroxyb;Hydrochinon acid;kyselinagentisinova
CBNumber:
CB5853669
Molecular Formula:
C7H6O4
Formula Weight:
154.12
MOL File:
490-79-9.mol

2,5-Dihydroxybenzoic acid Properties

Melting point:
204-208 °C(lit.)
Boiling point:
237.46°C (rough estimate)
Density 
1.3725 (rough estimate)
refractive index 
1.6400 (estimate)
storage temp. 
Store below +30°C.
solubility 
It is soluble in alcohol and ether.
pka
2.97(at 25℃)
form 
Crystalline Powder
color 
White to light beige
Water Solubility 
soluble
Merck 
14,4398
BRN 
2209119
InChIKey
WXTMDXOMEHJXQO-UHFFFAOYSA-N
CAS DataBase Reference
490-79-9(CAS DataBase Reference)
NIST Chemistry Reference
2,5-Dihydroxybenzoic acid(490-79-9)
EPA Substance Registry System
Benzoic acid, 2,5-dihydroxy-(490-79-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  LY3850000
Hazard Note  Harmful
TSCA  Yes
HS Code  29182990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

2,5-Dihydroxybenzoic acid price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 149357 2,5-Dihydroxybenzoic acid 98% 490-79-9 10g $25 2018-11-13 Buy
Sigma-Aldrich 149357 2,5-Dihydroxybenzoic acid 98% 490-79-9 25g $43.1 2018-11-13 Buy
TCI Chemical D0569 2,5-Dihydroxybenzoic Acid >98.0%(HPLC)(T) 490-79-9 25g $41 2018-11-22 Buy
TCI Chemical D0569 2,5-Dihydroxybenzoic Acid >98.0%(HPLC)(T) 490-79-9 500g $406 2018-11-22 Buy
Alfa Aesar A11459 2,5-Dihydroxybenzoic acid, 99% 490-79-9 100g $114 2018-11-13 Buy

2,5-Dihydroxybenzoic acid Chemical Properties,Uses,Production

Description

Gentisic acid is a dihydroxy benzoic acid. It is a derivative of benzoic acid and a minor (1 %) product of the metabolic break down of aspirin, excreted by the kidneys.
It is also found in the African tree Alchornea cordifolia and in wine.

Chemical Properties

white to light beige crystalline powder

Uses

Medicine, as sodium gentisate (analgesic).

Definition

ChEBI: A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.

Production Methods

Gentisic acid is produced by carboxylation of hydroquinone.
C6H4(OH)2 + CO2 → C6H3(CO2H)(OH)2
This conversion is an example of a Kolbe–Schmitt reaction.

Application

As a hydroquinone , gentisic acid is readily oxidized and is used as an antioxidant excipient in some pharmaceutical preparations. In the laboratory, it is used as a sample matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry , and has been shown to conveniently detect peptides incorporating the boronic acid moiety by MALDI .

Safety Profile

Poison bp intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise gentisic acid from hot water or *benzene/acetone. Dry it in a vacuum desiccator over silica gel. [Beilstein 10 H 384, 10 IV 1441.]

2,5-Dihydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products


2,5-Dihydroxybenzoic acid Suppliers

Global( 308)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 407 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 533 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
HaBo Hong Kong Co., Limited.
+86-25-18512596065
info@habotech.com CHINA 1037 58

View Lastest Price from 2,5-Dihydroxybenzoic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-14 2,5-Dihydroxybenzoic acid
490-79-9
US $1.00 / kg 1kg as customer's need 10kg career henan chemical co
2018-11-05 2,5-Dihydroxy benzoic acid
490-79-9
US $50.00 / KG 1KG 99% 10 mt Hebei Huanhao Biotechnology Co., Ltd.
2018-08-01 Gentisic acid
490-79-9
US $150.00 / KG 1KG 99% 100ton/month Hebei Minshang Biotechnology Co., Ltd

2,5-Dihydroxybenzoic acid Spectrum


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