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Lithium amide

Preparation Reactions
Lithium amide
Lithium amide structure
CAS No.
7782-89-0
Chemical Name:
Lithium amide
Synonyms
lithamide;Lithiumamid;Lithioamine;Aminolithium;Litium amide;LITHIUM AMIDE;lithium azanide;Lithiumamide,95%;Lithium amide (Li(NH2));Lithiumamideoffwhitepowder
CBNumber:
CB5854323
Molecular Formula:
H2LiN
Formula Weight:
22.96
MOL File:
7782-89-0.mol

Lithium amide Properties

Melting point:
373 °C
Boiling point:
430 °C
Density 
1.178 g/mL at 25 °C(lit.)
refractive index 
1.178g/mL
storage temp. 
water-free area
solubility 
Slightly soluble in ethanol and liquid ammonia. Insoluble in anhydrous ether, benzene and toluene.
form 
Powder
Specific Gravity
1.178
color 
off-white
Water Solubility 
reacts
Sensitive 
Air & Moisture Sensitive
Merck 
14,5522
InChIKey
AFRJJFRNGGLMDW-UHFFFAOYSA-N
CAS DataBase Reference
7782-89-0(CAS DataBase Reference)
EPA Substance Registry System
Lithium amide (7782-89-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS05
Signal word  Danger
Hazard statements  H318-H261-H314
Precautionary statements  P231+P232-P280-P305+P351+P338-P310-P422-P309-P370+P378m-P402
Hazard Codes  F,C
Risk Statements  14/15-29-34-20/21/22-15-14-11
Safety Statements  26-36/37/39-43-45-7/8-43B-16-3/7/9
RIDADR  UN 1390 4.3/PG 2
WGK Germany  2
RTECS  OJ5590000
TSCA  Yes
HazardClass  4.3
PackingGroup  II
HS Code  28530090
NFPA 704
1
1 2
W

Lithium amide price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 213217 Lithium amide powder, 95% 7782-89-0 5g $33.7 2019-12-02 Buy
Sigma-Aldrich 213217 Lithium amide powder, 95% 7782-89-0 100g $59.1 2019-12-02 Buy
Alfa Aesar L16023 Lithium amide, 95% 7782-89-0 25g $27.2 2019-12-02 Buy
Alfa Aesar L16023 Lithium amide, 95% 7782-89-0 100g $54.4 2019-12-02 Buy
Strem Chemicals 93-0306 Lithium amide, 95% 7782-89-0 50g $44 2019-12-02 Buy

Lithium amide Chemical Properties,Uses,Production

Preparation

Lithium amide is obtained by dissolution of lithium metal in liquid ammonia. The reaction is slow, but may be catalyzed by cobalt nitrate:
It also is obtained by passing gaseous ammonia over lithium hydride:
LiH + NH3 → LiNH2 + H2

Reactions

Lithium amide decomposes to imide when heated above 400°C: 2LiNH2 → Li2NH + NH3
It is used in several organic syntheses. Some of these synthetic reactions are based on the mechanism that the terminal alkynes react with the stronger base, the anion, forming the weaker conjugate base:

It converts vic dibromide to bromoalkene and then alkyne:

Ketones can be converted into alkynes:

Chemical Properties

white to grey fine powder

Uses

Reagent for synthesis of: Antiinflamatory and preoresolving protectin D11 Chemotype dipeptidyl peptidase IV inhibitors2 Sterically congested triarylamines3 Dyes displaying large Stokes shifts4 GM1 ganglioside derivatives5Reagent for cross-coupling of aryl chlorides and amines6

Uses

In Claisen condensations, alkylation of nitriles and ketones, synthesis of ethynyl Compounds, acetylenic carbinols.

Preparation

Lithium amide, LiNH2 , may be considered the ammonia analogue of lithium hydroxide in the water system. Lithium amide may be prepared from lithium hydride or lithium metal and ammonia. Industrial preparations use lithium hydride as a starting material.
The reaction of lithium metal in a stream of ammonia gas at about 400°C may be used successfully as a preparative method. Lithium may also be reacted with liquid ammonia in the presence of an iron compound as a catalyst.
Since amide ion is the strongest base which can exist in ammonia, lithium amide is a very strong base. The compound has a low solubility in liquid ammonia. Lithium amide is hydrolyzed by water to yield lithium hydroxide and ammonia. It is readily oxidized. For example, the substance may be oxidized with dinitrogen oxide to yield lithium azide. Amides of the alkali metals in general must be guarded against air oxidation to prevent the formation of potentially explosive substances.

General Description

White crystalline powder with an odor of ammonia. Denser than water.

Reactivity Profile

Powdered Lithium amide is highly reactive. A strong base. Reacts to release toxic ammonia gas with water. Forms explosive peroxide on storage.

Health Hazard

Highly toxic: contact with water produces toxic gas, may be fatal if inhaled. Inhalation or contact with vapors, substance or decomposition products may cause severe injury or death. May produce corrosive solutions on contact with water. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control may cause pollution.

Fire Hazard

Produce flammable and toxic gases on contact with water. May ignite on contact with water or moist air. Some react vigorously or explosively on contact with water. May be ignited by heat, sparks or flames. May re-ignite after fire is extinguished. Some are transported in highly flammable liquids. Containers may explode when heated. Runoff may create fire or explosion hazard.

Safety Profile

A powerful irritant to skin, eyes, and mucous membranes. Flammable when exposed to heat or flame. Ammonia is liberated and lithmm hydroxide is formed when this compound is exposed to moisture. Reacts violently with water or steam to produce toxic and flammable vapors. Vigorous reaction with oxilzing materials. Exothermic reaction with acid or acid fumes. When heated to decomposition it emits very toxic fumes of LiO, NH3, and NO,. Used in synthesis of drugs, vitamins, steroids, and other organics. See also LITHIUM COMPOUNDS, AMIDES, AMMONIA, and LITHIUM HYDROXIDE.

Purification Methods

Purify it by heating at 400o while NH3 is passed over it in the upper of two crucibles (the upper crucible is perforated). The LiNH2 will drip into the lower crucible through the holes in the upper crucible. The product is cooled in a stream of NH3. Protect it from air and moisture, store it under N2 in a clear glass bottle sealed with paraffin. Store it in small quantities so that all the material is used once the bottle is opened. If the colour of the amide is yellow, it should be destroyed as it is likely to have oxidised and to EXPLODE. On heating above 450o it is decomposed to Li2NH, which is stable up to 750-800o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I p 463 1963, Greenlee & Henne Inorg Synth II 135 1953.]

Lithium amide Preparation Products And Raw materials

Raw materials

Preparation Products


Lithium amide Suppliers

Global( 98)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
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GuangTuo Chemical (Shanghai) Co., Ltd. 021-60899189-8001 18918189673
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View Lastest Price from Lithium amide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-01 Lithium amide
7782-89-0
US $1.00 / KG 1KG 99% 100MT Henan Xiangtong Chemical Co., Ltd.
2020-01-10 Lithium amide
7882-89-0
US $1.00 / KG 1KG 99% 100KG Career Henan Chemical Co
2018-08-15 Lithium amide
7782-89-0
US $1.00 / KG 1G 98% 100KG career henan chemical co

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