Melperone hydrochloride
- CAS No.
- 1622-79-3
- Chemical Name:
- Melperone hydrochloride
- Synonyms
- Melperone HCl;Melperone-d4 HCl;MELPERONE HYDROCHLORIDE;Methylperone hydrochloride;1(4-Fluorophenol)-4-(4-methyl-1-piperidinyl)-1-butanone;1-[3-(p-fluorobenzoyl)propyl]-4-methylpiperazinium chloride;1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one HCl;1-(4-Fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanonehydrochloride;1-(4-Fluorophenyl)-4-(4-Methylpiperidin-1-yl)butan-1-one hydrochloride;1-Butanone, 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-, hydrochloride (1:1)
- CBNumber:
- CB5900763
- Molecular Formula:
- C15H22ClFN2O
- Molecular Weight:
- 300.7993832
- MDL Number:
- MFCD00270922
- MOL File:
- 1622-79-3.mol
| Melting point | 209-211℃ |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Light Brown |
| FDA UNII | 88G640374K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361-H302-H332-H312 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| Toxicity | LD50 in rats, mice (mg/kg): 330, 230 orally; 40, 35 i.v. (Christensen) | |||||||||
| NFPA 704 |
|
Melperone hydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19770 | Melperone (hydrochloride) ≥98% | 1622-79-3 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19770 | Melperone (hydrochloride) ≥98% | 1622-79-3 | 10mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 19770 | Melperone (hydrochloride) ≥98% | 1622-79-3 | 25mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19770 | Melperone (hydrochloride) ≥98% | 1622-79-3 | 50mg | $178 | 2024-03-01 | Buy |
| Tocris | 2495 | Melperonehydrochloride ≥99%(HPLC) | 1622-79-3 | 50 | $305 | 2021-12-16 | Buy |
Melperone hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Eunerpan,Nordmark,W. Germany,1965
Uses
Melperone Hydrochloride is an atypical antipsychotic drug.
Uses
Melperone hydrochloride is a neuroleptic butyrophenone. Melperone is also an antiarrhythmic agent. Melperone is an effective atypical antipsychotic drug used in the treatment of schizophrenia.
Manufacturing Process
A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C.
Therapeutic Function
Neuroleptic
Biological Activity
Atypical neuroleptic; 5-HT 2A /D 2 receptor antagonist (K i values are 120 and 180 nM respectively). Causes an increase in dopamine levels in the medial prefrontal cortex (mPFC) and nucleus accumbens and an increase in ACh in the mPFC. Also binds adrenergic α 1 and α 2 receptors (K i values are 180 and 150 nM respectively).
Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. A neuroleptic drug used to treat anxiety and confusion. When heated to decomposition it emits very toxic fumes of F-, NOx, and HCl.
Melperone hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1667 | 59 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |