Mesdopetam L-tartrate salt
- CAS No.
- 2562346-14-7
- Chemical Name:
- Mesdopetam L-tartrate salt
- Synonyms
- IRL790 hemitartrate;Mesdopetam hemitartrate;Mesdopetam L-tartrate salt;3-?dihydroxybutanedioat?e (2:1);Mesdopetam · 1/2 L-tartrate salt;N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-;1-?Propanamine, N-?[2-?[3-?fluoro-?5-?(methylsulfonyl)?phenoxy]?ethyl]?-?, (2R,?3R)?-?2,?3-?dihydroxybutanedioat?e (2:1);Dopamine Receptor,properties,neurotransmission,inhibit,stabilizing,disease,psychomotor,Mesdopetam hemitartrate,Inhibitor,Parkinson
- CBNumber:
- CB59735168
- Molecular Formula:
- C16H24FNO9S
- Molecular Weight:
- 425.42
- MDL Number:
- MOL File:
- 2562346-14-7.mol
Mesdopetam L-tartrate salt Chemical Properties,Uses,Production
Biological Activity
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (Ki=90 nM; IC50=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease[1][2]. Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg; s.c.) hemitartrate dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80[1].Mesdopetam (10 mg/kg; intraperitoneally; fourteen-week-old male C57BL/J mice) hemitartrate promotes a sedative effect similar to haloperidol with significantly reduced total distance traveled and reduced average speed[2].
References
[1]. Waters S, et al. Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. J Pharmacol Exp Ther. 2020;374(1):113-125. [2]. Becanovic K, et al. Effects of a Novel Psychomotor Stabilizer, IRL790, on Biochemical Measures of Synaptic Markers and Neurotransmission. J Pharmacol Exp Ther. 2020;374(1):126-133.
Mesdopetam L-tartrate salt Preparation Products And Raw materials
Raw materials
Preparation Products
Mesdopetam L-tartrate salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3427 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10006 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Changzhou Ruikaijia polymer material Technology Co., LTD | 3693241975 | kairuijiabio@126.com | China | 6526 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |