AG 957
- CAS No.
- 140674-76-6
- Chemical Name:
- AG 957
- Synonyms
- AG 957;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;LAVENDUSTIN C ANALOG;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE;Benzoic acid, 4-[[(2,5-dihydroxyphenyl)methyl]amino]-, methyl ester;Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate;paxillin,NSC654705,c-Abl,Bcr-Abl,lipopolysaccharide,Tyrphostin AG-957,integrins,leukemia,tyrosine,Tyrphostin AG 957,hematopoiesis,AG-957,NSC-654705,AG 957,NSC 654705,AG957,Tyrphostin AG957,kinase,BCR/ABL,inhibit,cytoskeleton,Inhibitor,Chronic,myelogenous
- CBNumber:
- CB6100142
- Molecular Formula:
- C15H15NO4
- Molecular Weight:
- 273.28
- MDL Number:
- MFCD01074970
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
AG 957 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17259 | AG957 ≥95% | 140674-76-6 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17259 | AG957 ≥95% | 140674-76-6 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 17259 | AG957 ≥95% | 140674-76-6 | 10mg | $213 | 2024-03-01 | Buy |
| TRC | T947970 | TyrphostinAG957 | 140674-76-6 | 1mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | C5826 | AG957 | 140674-76-6 | 5mg | $124 | 2021-12-16 | Buy |
AG 957 Chemical Properties,Uses,Production
Description
Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.
Uses
Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Also, it causes metabolic alterations in K562 cells. It is a COVID19-related research product.
Definition
ChEBI: 4-[(2,5-dihydroxyphenyl)methylamino]benzoic acid methyl ester is an aromatic amine.
References
[1]. anafi m, gazit a, gilon c, et al. selective interactions of transforming and normal abl proteins with atp, tyrosine-copolymer substrates, and tyrphostins. j biol chem. 1992 mar 5;267(7):4518-23.
[2]. kaur g, gazit a, levitzki a, et al. tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in k562 chronic myelogenous leukemia. anticancer drugs. 1994 apr;5(2):213-22.
[3]. jamieson l, carpenter l, biden tj, et al. protein kinase ciota activity is necessary for bcr-abl-mediated resistance to drug-induced apoptosis. j biol chem. 1999 feb 12;274(7):3927-30.
[4]. fu p, usatyuk pv, lele a, et al. c-abl mediated tyrosine phosphorylation of paxillin regulates lps-induced endothelial dysfunction and lung injury. am j physiol lung cell mol physiol. 2015 may 15;308(10):l1025-38.
AG 957 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 957 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai CR Corporation Limited | 4006653949 | fred.wen@crcorporation.cn | China | 10108 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |