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Benzamidine hydrochloride

Benzamidine hydrochloride
Benzamidine hydrochloride structure
CAS No.
1670-14-0
Chemical Name:
Benzamidine hydrochloride
Synonyms
BENZAMIDINE HCL;BENZAMIDE HCL H2O;Benzamidine hydrochl;benzamidiniumchloride;Benzamidin Hydrochloride;BENZAMIDINE HYDROCHLORIDE;amidinobenzenehydrochloride;BenziMidaMide hydrochloride;benzamidine hydroxychloride;BenzamidineHydrochloride>
CBNumber:
CB6100733
Molecular Formula:
C7H9ClN2
Formula Weight:
156.61
MOL File:
1670-14-0.mol

Benzamidine hydrochloride Properties

Melting point:
86-88 °C(lit.)
storage temp. 
2-8°C
solubility 
DMF: 25 mg/ml
DMSO: 25 mg/ml
Ethanol: 10 mg/ml
PBS (pH 7.2): 3 mg/ml
form 
Powder
color 
White to off-white
Water Solubility 
soluble
BRN 
3594959
InChIKey
LZCZIHQBSCVGRD-UHFFFAOYSA-N
CAS DataBase Reference
1670-14-0(CAS DataBase Reference)
EPA Substance Registry System
Benzenecarboximidamide, monohydrochloride (1670-14-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36
WGK Germany  3
RTECS  CV6260000
3-21
HS Code  29252900

Benzamidine hydrochloride price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 199001-M Benzamidine, Hydrochloride Inhibitor of trypsin and trypsin-like enzymes. 1670-14-0 5gm-m $55.7 2021-12-16 Buy
Sigma-Aldrich 199001-M Benzamidine, Hydrochloride - CAS 1670-14-0 - Calbiochem Inhibitor of trypsin and trypsin-like enzymes. 1670-14-0 5 g $55.7 2021-12-16 Buy
Sigma-Aldrich 63226 Benzamidine hydrochloride 1 M solution 1670-14-0 1 mL $59.4 2021-12-16 Buy
Sigma-Aldrich 199001-M Benzamidine, Hydrochloride Inhibitor of trypsin and trypsin-like enzymes. 1670-14-0 25gm-m $101 2021-12-16 Buy
Sigma-Aldrich 199001-M Benzamidine, Hydrochloride - CAS 1670-14-0 - Calbiochem Inhibitor of trypsin and trypsin-like enzymes. 1670-14-0 25 g $101 2021-12-16 Buy

Benzamidine hydrochloride Chemical Properties,Uses,Production

Description

Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

Chemical Properties

white to off-white powder

Uses

Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.

Preparation

To a stainless steel rocking autoclave equipped with a stirrer is added 103.0 gm (1.0 mole) of benzonitrile, 214.0 gm (4.0 mole) of ammonium chloride, and 306.0 gm (18.0 mole) of ammonia is introduced by means of a transfer bomb. The reaction mixture is heated at 150°C for 18 hr (pressure: 1300-6500 psig), cooled, and, with appropriate precautions for the safe control of the excess ammonia, is vented to atmospheric pressure. The reaction mixture is extracted with ether to remove approximately 5% unreacted benzonitrile, and then extracted with hot acetonitrile or ethanol to separate the amidine hydrochloride from the unreacted ammonium chloride. Concentration of the latter affords 120.5 gm (77%) of benzamidine hydrochloride, m.p. 161-163°C.
Preparation of Benzamidine Hydrochloride

Biological Activity

Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 μM, 21 μM, 20 μM and 110 μM for uPA, trypsin, tryptase and factor Xa, respectively.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx, HCl, and Cl-.

in vitro

Benzamidine hydrochloride has weak inhibition for tPA and thrombin, with Kis of 750 μM and 320 μM, respectively.

Benzamidine hydrochloride synthesis

613-92-3
1670-14-0
Synthesis of Benzamidine hydrochloride from BENZAMIDOXIME HYDROCHLORIDE

Benzamidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Benzamidine hydrochloride Suppliers

Global( 342)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mascot I.E.Co .,Ltd.
+8613584504415 +86-0519-85010339
info@mascot-ie.com China 327 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15426 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

View Lastest Price from Benzamidine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-13 Benzamidine hydrochloride
1670-14-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Benzamidine hydrochloride
1670-14-0
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2020-03-16 Benzamidine hydrochloride
1670-14-0
US $1.00-0.00 / KG 1KG 99%+ 10000KG Shaanxi Dideu Medichem Co. Ltd

Benzamidine hydrochloride Spectrum


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