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E-7820

CAS No.
289483-69-8
Chemical Name:
E-7820
Synonyms
E-7820;CS-2701;ER 68203-00;E 7820; E-7820;ER68203-00;E7820;E-7820;E 7820;289483-69-8;3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide;N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide;Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-;E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820;3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
CBNumber:
CB61011214
Molecular Formula:
C17H12N4O2S
Molecular Weight:
336.37
MDL Number:
MFCD09833234
MOL File:
289483-69-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

E-7820 Properties

Boiling point 626.2±65.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:67.0(Max Conc. mg/mL);199.19(Max Conc. mM)
form A crystalline solid
pka 8.17±0.30(Predicted)
FDA UNII TVH5K7949N
NCI Drug Dictionary E7820

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

E-7820 price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25502 E7820 ≥98% 289483-69-8 5mg $37 2024-03-01 Buy
Cayman Chemical 25502 E7820 ≥98% 289483-69-8 10mg $68 2024-03-01 Buy
Cayman Chemical 25502 E7820 ≥98% 289483-69-8 50mg $283 2024-03-01 Buy
Cayman Chemical 25502 E7820 ≥98% 289483-69-8 100mg $530 2024-03-01 Buy
Tocris 6785 E7820 ≥98%(HPLC) 289483-69-8 10 $207 2021-12-16 Buy
Product number Packaging Price Buy
25502 5mg $37 Buy
25502 10mg $68 Buy
25502 50mg $283 Buy
25502 100mg $530 Buy
6785 10 $207 Buy

E-7820 Chemical Properties,Uses,Production

Description

E7820 is a sulfonamide derivative and an angiogenesis inhibitor that inhibits bFGF- and VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively). It inhibits bFGF- and VEGF-stimulated tube formation of HUVECs in a concentration-dependent manner (IC50s = 0.2 and 0.24 μg/ml, respectively). E7820 selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs. In vivo, E7820 (200 and 400 mg/kg) reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model. It also reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models, completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models, and inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models.

storage

Store at -20°C

E-7820 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
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Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 877 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2989 60
E-7820 ER 68203-00 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide E 7820; E-7820 CS-2701 ER68203-00;E7820;E-7820;E 7820;289483-69-8 Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)- E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239 289483-69-8