Fasudil hydrochloride
- CAS No.
- 105628-07-7
- Chemical Name:
- Fasudil hydrochloride
- Synonyms
- CS-520;HA-1077;FASUDEL;CS-1572;Fasudil-HA;FASUDIL HCL;HA-1077 HCl;FASUDIL, MONOHCL;Fasudil (HA-1077);Fasudil HCl, >=99%
- CBNumber:
- CB6101699
- Molecular Formula:
- C14H18ClN3O2S
- Molecular Weight:
- 327.83
- MDL Number:
- MFCD00943198
- MOL File:
- 105628-07-7.mol
| Melting point | 220.5°; mp 219.3° (Shirotani) |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O: >200 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water and dimethyl sulfoxide. Insoluble in ethanol. |
| Merck | 14,3942 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H |
| InChIKey | LFVPBERIVUNMGV-UHFFFAOYSA-N |
| SMILES | N1(S(C2=CC=CC3=C2C=CN=C3)(=O)=O)CCCNCC1.[H]Cl.[H]Cl |
| CAS DataBase Reference | 105628-07-7(CAS DataBase Reference) |
| FDA UNII | SQ04N8S7BR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36-60 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HM4031166 | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga) | |||||||||
| NFPA 704 |
|
Fasudil hydrochloride price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0839 | Fasudil Hydrochloride >98.0%(HPLC) | 105628-07-7 | 100mg | $99 | 2024-03-01 | Buy |
| Alfa Aesar | J60751 | Fasudil monohydrochloride, 99+% | 105628-07-7 | 250mg | $243.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60751 | Fasudil monohydrochloride, 99+% | 105628-07-7 | 1g | $623 | 2024-03-01 | Buy |
| Alfa Aesar | J60751 | Fasudil monohydrochloride, 99+% | 105628-07-7 | 500mg | $361.65 | 2024-03-01 | Buy |
| Tocris | 0541 | Fasudil Hydrochloride ≥98%(HPLC) | 105628-07-7 | 10 | $162 | 2021-12-16 | Buy |
Fasudil hydrochloride Chemical Properties,Uses,Production
Indications and Usage
Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Mechanisms of Action
Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
Adverse reactions
Adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
Warnings and Precautions
Patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
Description
Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.
Originator
Asahi Chemical (Japan)
Uses
Fasudil monohydrochloride is used in the prevention and treating cardiovascular and cerebrovascular diseases. It is also used in the inhibition of proliferation of vascular smooth muscle cells. It serves as a selective Rho-associated protein kinase (ROCK) inhibitor. Further, it protects against methyl mercury-induced axonal degeneration.
Uses
vasodilator, potent Rho-kinase inhibitor
Definition
ChEBI: Fasudil hydrochloride is a hydrochloride obtained by reaction of fasudil with one equivalent of hydrochloric acid. It has a role as an antihypertensive agent, a calcium channel blocker, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a neuroprotective agent, a nootropic agent and a vasodilator agent. It contains a fasudil(1+).
brand name
Eril
storage
Room temperature
References
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 2) Anwar et al. (2013), Signal transduction and modulating pathways in tryptamine-evoked vasopressor responses of the rat isolated perfused mesenteric bed; Vascul. Pharmacol., 58 140 3) Jiang et al. (2012), Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice; Int. J. Mol. Sci., 13 8293
Fasudil hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
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View Lastest Price from Fasudil hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-16 | Fasudil hydrochloride
105628-07-7
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2023-11-25 | Fasudil hydrochloride
105628-07-7
|
US $30.00-10.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-09-18 | FASUDEL
105628-07-7
|
US $28.30 / kg | 1kg | 99% | 15MT | Wuhan Han Sheng New Material Technology Co.，Ltd |
-
- Fasudil hydrochloride
105628-07-7
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- Fasudil hydrochloride
105628-07-7
- US $30.00-10.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- FASUDEL
105628-07-7
- US $28.30 / kg
- 99%
- Wuhan Han Sheng New Material Technology Co.，Ltd